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Health-related quality of life in Japanese low-risk prostate cancer patients choosing active surveillance: 3-year follow-up from PRIAS-JAPAN

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World Journal of Urology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the health-related quality of life (HRQoL) of Japanese men on active surveillance (AS) in the Prostate cancer Research International Active Surveillance study in Japan (PRIAS-JAPAN).

Methods

Participants were included in the PRIAS-JAPAN HRQoL study between January 2010 and March 2016. Their general HRQoL was assessed using a validated Japanese version of the Short-Form 8 Health Survey (SF-8) at enrolment and annually thereafter until discontinuation of AS. The SF-8 mental component summary (MCS) and physical component summary (PCS) of men on AS were compared with scores of the general population (norm-based score [NBS]: 50) and MCS and PCS scores for men following AS were analysed over time. We tested whether MCS and PCS scores over time explained discontinuation of AS.

Results

Five hundred and twenty-five patients enrolled, and the median age at baseline was 68 years. At enrolment and after 1-, 2-, and 3-year follow-ups, the PCS and MCS scores were significantly higher than the NBS of the general Japanese population except for the median PCS at 3 years. We found that age at diagnosis and time on AS negatively affected the PCS score of men on AS, while every additional year on AS led to a 0.27 point increase in MCS scores. Neither PCS nor MCS were predictors for discontinuation of AS.

Conclusion

Japanese men following an AS strategy for 3 years reported better HRQoL compared with the general population, indicating that monitoring Japanese low-risk prostate cancer patients can be an effective treatment strategy.

Study registration

Clinical trial registry—UMIN (University Hospital Medical Information Network); UMIN000002874 (2009/12/11)

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Availability of data and material

The corresponding author can be contacted regarding the use of the data. The data are not publicly available.

Code availability

A software application has been used for the code.

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Acknowledgements

We thank Drs Toshiki Tanikawa, Toshihiro Saito, Kazuhiro Kobayashi, Tadashi Matsuda, Hidefumi Kinoshita, Masatoshi Eto, Junichi Inokuchi, Akito Terai, Hirohito Naito, Yoshiko Maeda, Tomohiko Ichikawa, Masahiro Sugiura, Hiroyoshi Suzuki, Naoto Kamiya, Takumi Endo, Osamu Ogawa, Shusuke Akamatsu, Koichiro Akakura, Toshiyuki Kamoto, Naoki Terada, Isao Hara, Kazuhiro Suzuki, Hiroaki Matsumoto, Kiyotaka Kawashima, Fumimasa Fukuta, Naoya Masumori, Akira Miyajima, Masahiro Nitta, Takamitsu Inoue, Sohei Kanda, Kazuo Nishimura, Masashi Nakayama, Yasutomo Nakai, Takayuki Sugiyama, Hideaki Miyake, Norihiko Tsuchiya, Hisashi Kawazoe, Seiichi Saito, Ryu Kimura, Minoru Miyazato, Hiroomi Kanayama, Yoshito Kusuhara, Tomomi Kamba, Yoji Murakami, Haruki Kume, Masaki Nakamura, Jun Teishima, Takeshi Ueno, Mitsugu Kanehira, Norio Nonomura, Motohide Uemura, Ken-ichi Tabata, Hideyasu Tsumura, Hiroshi Okuno, Toshihiro Uchida, Osamu Ukimura, Takumi Shiraishi, Hiroshi Fukuhara, Yasuo Yamamoto, Tadashi Murata, Kazuto Ito, Yukio Kageyama, Yasuyuki Sakai, Yukio Naya, Satoko Kojima, Hiroshi Masuda, Hideki Sakai, Tomoaki Hakariya, Yoshihiko Tomita, Takashi Kasahara, Naoki Nishimoto, and Yoshio Ueno for their great contribution to this study. The authors thank all contributions for PRIAS-JAPAN.

Funding

Not applicable.

Author information

Authors and Affiliations

  1. Department of Urology, Kagawa University Faculty of Medicine, 1750-1 Ikenobe, Kita-gun, Miki-cho, Kagawa, 761-0793, Japan

    Hiromi Hirama, Mikio Sugimoto, Takuma Kato & Yoshiyuki Kakehi

  2. Department of Hygiene, Faculty of Medicine, Kagawa University Hospital, Miki, Kagawa, Japan

    Nobuyuki Miyatake

  3. Department of Urology, Erasmus University Medical Center, Rotterdam, The Netherlands

    Lionne D. F. Venderbos, Sebastiaan Remmers & Monique J. Roobol

  4. Department of Urology, Harasanshin Hospital, Fukuoka, Japan

    Kenichiro Shiga & Akira Yokomizo

  5. Department of Urology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan

    Koji Mitsuzuka

  6. Department of Renal and Genito-Urinary Surgery, Graduate School of Medicine, Hokkaido University, Sapporo, Hokkaido, Japan

    Ryuji Matsumoto, Takahiro Osawa & Takashige Abe

  7. Department of Urology, Jikei University School of Medicine, Tokyo, Japan

    Hiroshi Sasaki & Shin Egawa

  8. Department of Urology, Shikoku Cancer Center, Matsuyama, Ehime, Japan

    Iku Ninomiya & Katsuyoshi Hashine

Authors
  1. Hiromi Hirama
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  2. Mikio Sugimoto
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  3. Nobuyuki Miyatake
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  4. Takuma Kato
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  5. Lionne D. F. Venderbos
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  6. Sebastiaan Remmers
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  7. Kenichiro Shiga
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  8. Akira Yokomizo
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  9. Koji Mitsuzuka
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  10. Ryuji Matsumoto
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  11. Takahiro Osawa
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  12. Takashige Abe
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  13. Hiroshi Sasaki
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  14. Shin Egawa
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  15. Iku Ninomiya
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  16. Katsuyoshi Hashine
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  17. Monique J. Roobol
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  18. Yoshiyuki Kakehi
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Contributions

HH: data collection and management, statistics, and manuscript writing. MS and NM: manuscript editing. TK: data collection and management. LV: manuscript writing/editing. SR: statistics and manuscript editing. KS, AY, KM, RM, TO, TA, HS, SE, IN and KH: data collection. MR and YK: protocol/project development. The first draft of the manuscript was written by HH and all the authors provided feedback to previous versions of the manuscript. All the authors read and approved the final manuscript.

Corresponding author

Correspondence to Hiromi Hirama.

Ethics declarations

Conflict of interest

Dr. Yokomizo reports receiving advisory board fees and lecture fees from Astellas Pharma, Bayer and Sanofi. The other authors declare that they have no conflicts of interest.

Research involving human participants

This study was performed in line with the principles of the Declaration of Helsinki. The study protocol was first approved by the Institutional Review Board of the Kagawa University, Faculty of Medicine (Ethics approval number: H21-041) and subsequently by the other participating sites.

Informed consent

Informed consent was obtained from all individual participants included in the study.

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Hirama, H., Sugimoto, M., Miyatake, N. et al. Health-related quality of life in Japanese low-risk prostate cancer patients choosing active surveillance: 3-year follow-up from PRIAS-JAPAN. World J Urol 39, 2491–2497 (2021). https://doi.org/10.1007/s00345-020-03494-4

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  • DOI: https://doi.org/10.1007/s00345-020-03494-4

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