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Equine synteny mapping of comparative anchor tagged sequences (CATS) from human Chromosome 5

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Abstract.

Comparative anchor tagged sequences (CATS) from human Chromosome 5 (HSA5) were used as PCR primers to produce molecular markers for synteny mapping in the horse. Primer sets for 21 genes yielded eight horse-specific markers, which were mapped with the UC Davis horse–mouse somatic cell hybrid panel into two synteny groups: UCD14 and UCD21. These data, in conjunction with earlier human chromosome painting studies of the horse karyotype and synteny mapping of horse microsatellite markers physically mapped by FISH, confirm the assignment of UCD21 to ECA21 and suggest that UCD14 is located on ECA14. In addition, our results can be used to substantiate previously published data which indicate that ECA21 contains material orthologous to HSA5p and HSA5q, and to propose an approximate region for an evolutionary chromosomal rearrangement event.

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Authors and Affiliations

  1. University of California Davis, Veterinary Genetics Laboratory, Davis, California 95616-8744, USA, , , , , , US

    Alexandre R. Caetano & Ann T. Bowling

  2. University of California Davis, Department of Animal Science, Davis, California 95616-8744, USA, , , , , , US

    James D. Murray

  3. Laboratory of Genomic Diversity, National Cancer Institute, Frederick Cancer Research and Development Center, Building 560, Room 21-105, Frederick, Maryland 21702-1201, USA, , , , , , US

    Leslie A. Lyons & Stephen J. O'Brien

  4. Department of Biological Sciences, East Tennessee State University, Johnson City, Tennessee 37614, USA, , , , , , US

    Thomas F. Laughlin

Authors
  1. Alexandre R. Caetano
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  2. Leslie A. Lyons
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  3. Thomas F. Laughlin
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  4. Stephen J. O'Brien
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  5. James D. Murray
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  6. Ann T. Bowling
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Additional information

Received: 1 February 1999 / Accepted: 12 July 1999

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Caetano, A., Lyons, L., Laughlin, T. et al. Equine synteny mapping of comparative anchor tagged sequences (CATS) from human Chromosome 5. 10, 1082–1084 (1999). https://doi.org/10.1007/s003359901165

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  • DOI: https://doi.org/10.1007/s003359901165

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