References
Breathnach R, Chambon P (1981) Organization and expression of eukaryotic split genes coding for proteins. Annu Rev Biochem 50, 349–383
Burchell B, Coughtrie MHW (1989) UDP-Glucuronosyltransferases. Pharmacol Ther 43, 261–289
Burchell B, Nebert DW, Nelson DR, Bock KW, Iyanagi T, Jansen PLM, Lancet T, Mulder GJ, Roy Chowdhury J, Siest G, Tephly TR, Mackenzie PI (1991) The UDP-glucuronosyltransferase gene superfamily. Suggested nomenclature based on evolutionary divergence. DNA Cell Biol 10, 487–494
Cavalier-Smith T (1991) Intron phylogeny: a new hypothesis. Trends Genet 7, 145–148
Fournel-Gigleux S, Jackson MR, Wooster R, Burchell B (1989) Expression of a human liver cDNA encoding a UDP-glucuronosyltransferase catalysing the glucuronidation of hyodeoxycholic acid in cell culture. FEBS Lett 243, 119–122
Grimsby J, Chen K, Wang I-J, Lan NC, Shih JC (1991) Human monoamine oxidase A and B genes exhibit identical exon-intron organization. Proc Natl Acad Sci USA 88, 3637–3641
Haque SJ, Petersen DD, Nebert DW, Mackenzie PI (1991) Isolation, sequence and developmental expression of rat UGT2B2: the gene encoding a constitutive UDP-glucuronosyltransferase that metabolizes etiocholanolone and androsterone. DNA Cell Biol 10, 515–524
Harding D, Jackson MR, Wooster R, Fournel-Gigleux S, Burchell B (1988) Cloning of human UDP-glucuronosyltransferase cDNAs. In Cellular and Molecular Aspects of Glucuronidation, G Siest, J Magdalou, B Burchell, eds. (INSERM/John Libbey Eurotext, Montrouge, France) 173, pp 13–20
Hawkins JD (1988) A survey of intron and exon lengths. Nucleic Acids Res 21, 9893–9908
Jackson MR, McCarthy LR, Harding D, Wilson S, Coughtrie MWH, Burchell B (1987) Cloning of a human liver microsomal UDP- glucuronosyltransferase cDNA. Biochem J 242, 581–588
Jin C-J, Miners JO, Lillywhite KJ, Mackenzie PI (1993) cDNA cloning and expression of two new members of the human liver UDP-glucuronosyltransferase 2B subfamily. Biochem Biophys Res Commun 194,496–503
Monaghan G (1994) Gene structure and physical mapping of the human UDP-glucuronosyltransferase subfamily 2 genes. PhD thesis, University of Dundee, Scotland
Monaghan G, Clarke DJ, Povey S, See CG, Boxer M, Burchell B (1994) Isolation of a human YAC contig encompassing a cluster of UGT2B genes and its regional localization to chromosome 4ql3. Genomics 23, 496–499
Ritter JK, Chen F, Sheen YY, Lubet RA, Owens IS (1992a) Two human liver cDNAs encode UDP-glucuronosyltransferase with 2 log differences in activity towards parallel substrates including hyodeoxycholic acid and certain estrogen derivatives. Biochemistry 31, 3409–3414
Ritter JK, Chen F, Sheen YY, Tran HM, Kimura S, Yeatman MT, Owens IS (1992b) A novel locus UGT1 encodes human bilirubin, phenol and other UDP-glucuronosyltransferase isoenzymes with identical carboxyl termini. J Biol Chem 287, 3257–3261
Rottmann WH, Deselms KR, Nicolas J, Camerato T, Holman PS, Green CJ, Tolan DR (1987) The complete amino acid sequence of the human aldolase C isozyme derived from genomic clones. Biochimie 69, 137–145
Tephly TR, Burchell B (1990) UDP-Glucuronosyltransferases: a family of detoxifying enzymes. Trends Pharmacol Sci 11, 276–279
Author information
Authors and Affiliations
Rights and permissions
About this article
Cite this article
Monaghan, G., Burchell, B. & Boxer, M. Structure of the human UGT2B4 gene encoding a bile acid UDP-glucuronosyltransferase. Mammalian Genome 8, 692–694 (1997). https://doi.org/10.1007/s003359900539
Received:
Accepted:
Issue Date:
DOI: https://doi.org/10.1007/s003359900539