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Mapping the homolog of the human Rb1 gene to Chromosome 14 of higher primates

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Abstract

The Rb1 gene has been implicated with retinoblastoma and is located on human Chromosome (Chr) 13ql4.2. A unique sequence human Rb1 cosmid DNA probe has been used to localize this region on apes’ Chr 14 by the FISH technique. The conservation of the Rb1 gene in higher primates at the corresponding equivalent chromosome locus (14ql4) of the human may serve as a phylogenetic marker to further trace the evolutionary pathway of human descent.

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References

  • Francke, U. (1976). Retinoblastoma and chromosome 13. Cytogenet. Cell Genet. 14, 131–134.

    Article  Google Scholar 

  • Friend, S.H., Bernards, R., Rogelj, S., Weinberg, R.A., Rapaport, J.M., Albert, D.M., Dryja, T.P. (1986). A human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma. Nature 323, 643–646.

    Article  PubMed  CAS  Google Scholar 

  • ISCN (1985). An International System for Human Cytogenetic Nomenclature: Birth Defects Original Article Series, Vol 21(1). New York: The National Foundation.

    Google Scholar 

  • Lee, W.-H., Bookstein, R., Hong, F., Young, L.-J., Shew, J.-Y., Lee, E.Y.-H.P. (1987). Human retinoblastoma susceptibility gene: cloning, identification and sequence. Science 235, 1394–1399.

    Article  PubMed  CAS  Google Scholar 

  • Lichter, P., Bentz, M., du Manoir, S., Joos, S. (1995). Comparative genomic hybridization. In: Human Chromosomes: Principles and Techniques, R.S. Verma, A. Babu, eds. (New York: McGraw-Hill), pp. 199–210.

    Google Scholar 

  • Verma, R.S., Babu, A. (1995). Human Chromosomes: Principles and Techniques. (New York: McGraw-Hill Inc.).

    Google Scholar 

  • Wienberg, J., Jauch, A., Stanyon, R., Cremer, T. (1990). Molecular cyto-taxonomy of primates by chromosomal in situ suppression hybridization. Genomics 8, 347–350.

    Article  PubMed  CAS  Google Scholar 

  • Yunis, J.J., Sawyer, J.R., Dunham, K. (1980). The striking resemblance of high resolution G-banded chromosomes of man and chimpanzee. Science 208, 1145–1148.

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Genetics, The Long Island College Hospital, Hicks Street at Atlantic Avenue, 11201, New York, SUNY Health Science Center, Brooklyn, USA

    R. S. Verma, K. H. Ramesh, R. V. Samonte & R. A. Conte

  2. Department of Pathology, Montefiore Medical Center, Albert Einstein College of Medicine, 10461, Bronx, NY, USA

    K. H. Ramesh

  3. Natural Sciences Research Institute, University of the Philippines Diliman, 1101, Quezon City, Philippines

    R. V. Samonte

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  1. R. S. Verma
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  2. K. H. Ramesh
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  3. R. V. Samonte
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  4. R. A. Conte
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Verma, R.S., Ramesh, K.H., Samonte, R.V. et al. Mapping the homolog of the human Rb1 gene to Chromosome 14 of higher primates. Mammalian Genome 7, 591–592 (1996). https://doi.org/10.1007/s003359900175

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  • DOI: https://doi.org/10.1007/s003359900175

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