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Expression and differential splicing of the mouse TSC2 homolog

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References

  • Carbonara, C., Longa, L., Grosso, E., Borrone, C., Garre, M.G., Brisigotti, M., Migone, N. (1994). 9q34 loss of heterozygosity in a tuberous sclerosis astrocytoma suggests a growth suppressor-like activity also for the TSC 1 gene. Hum. Mol. Genet. 3, 1829–1832.

    Article  PubMed  CAS  Google Scholar 

  • European Chromosome 16 Tuberous Sclerosis Consortium. (1993). Identification and characterization of the tuberous sclerosis gene on chromosome-16. Cell 75, 1305–1315.

    Google Scholar 

  • Fryer, A.E., Chalmers, A., Connor, J.M., Fraser, I., Povey, S., Yates, A.D., Yates Jr, W., Osborne, J.P. (1987). Evidence that the gene for tuberous sclerosis is on chromosome 9. Lancet 659–661.

  • Green, A.J., Yates Jr, W. (1995). Hamartomas from patients with tuberous sclerosis show loss of heterozygosity for chromosome 16pl3.3. Cytogenet. Cell Genet. 68, 181–181.

    Google Scholar 

  • Green, A.J., Sepp, T., Yates Jr, W. (1995). Hamartomas from patients with tuberous sclerosis show loss of heterozygosity for chromosome 9q34. J. Med. Genet. 32, 152–153.

    Article  Google Scholar 

  • Gunning, P., Ponte, P., Okayama, H., Engel, J., Blau, H., Kedes, L. (1983). Isolation and characterization of full-length cDNA clones for human alpha-actin, beta-actin and gamma-actin messenger-RNAs—skeletal but not cytoplasmic actins have an amino-terminal cysteine that is subsequently removed. Mol. Cell. Biol. 3, 787–795.

    PubMed  CAS  Google Scholar 

  • Haines, J.L., Short, M.P., Kwiatkowski, D.J., Jewell, A., Andermann, E., Bejjani, B., Yang, C.H., Gusella, J.F., Amos, J.A. (1991). Localization of one gene for tuberous sclerosis within 9q32-9q34, and further evidence for heterogeneity. Am. J. Hum. Genet. 49, 764–772.

    PubMed  CAS  Google Scholar 

  • Hino, O., Kleinszanto, A., Freed, J.J., Testa, J.R., Brown, D.Q., Vilensky, M., Yeung, R.S., Tartof, K.D., Knudson, A.G. (1993). Spontaneous and radiation-induced renal tumors in the Eker rat model of dominantly inherited cancer. Proc. Natl. Acad. Sci. USA 90, 327–331.

    Article  PubMed  CAS  Google Scholar 

  • Johnson, W. G., Yoshidome, H., Stenroos, E.S., Davidson, M.M. (1991). Origin of the neuron-like cells in tuberous sclerosis tissues. Ann. N.Y. Acad. Sci. 615, 211–219.

    Article  PubMed  CAS  Google Scholar 

  • Kandt, R.S., Haines, J.L., Smith, M, Northrup, H., Gardner, R., Short, M.P., Dumars, K., Roach, E.S., Steingold, S., Wall, S., Blanton, S.H., Flodman, P., Kwiatkowski, D.J., Jewell, A., Weber, J.L., Roses, A.D., Pericakvance, M.A. (1992). Linkage of an important gene locus for tuberous sclerosis to a chromosome 16 marker for polycystic kidney-disease. Nature Genet. 2, 37–41.

    Article  PubMed  CAS  Google Scholar 

  • Kobayashi, T., Hirayama, Y., Kobayashi, F., Kubo, Y., Hino, O. (1995a). A germline insertion in the tuberous sclerosis (tsc2) gene gives rise to the Eker rat model of dominantly inherited cancer. Nature Genet. 9, 70–74.

    Article  PubMed  Google Scholar 

  • Kobayashi, T., Nishizawa, M., Hirayama, Y., Kobayashi, E., Hino, O. (1995b). cDNA structure, alternative splicing and exon-intron organization of the predisposing tuberous sclerosis (tsc2) gene of the Eker rat model. Nucleic Acids Res. 23, 2608–2613.

    Article  PubMed  CAS  Google Scholar 

  • Kubo, Y., Mitani, H., Hino, O. (1994). Allelic loss at the predisposing locus in spontaneous and chemically-induced renal-cell carcinomas in the Eker rat. Cancer Res. 54, 2633–2635.

    PubMed  CAS  Google Scholar 

  • Lalier, T.E. (1991). Cell lineage and cell migration in the neural crest. Ann. N.Y. Acad. Sci. 615, 158–171.

    Article  Google Scholar 

  • Lyons, G.E., Buckingham, M.E., Tweedie, S., Edwards, Y.H. (1991). Carbonic anhydrase-iii, an early mesodermal marker, is expressed in embryonic mouse skeletal-muscle and notochord. Development 111, 233–244.

    PubMed  CAS  Google Scholar 

  • Olsson, P.G., Sutherland, H.F., Nowicka, U., Korn, B., Poustka, A., Frischauf, A.M. (1995). The mouse homolog of the tuberin gene (tsc2) maps to a conserved synteny group between mouse chromosome-17 and human 16pl3.3. Genomics 25, 339–340.

    Article  PubMed  CAS  Google Scholar 

  • Pawson, T., Gish, G.D. (1992). SH2 and sH3 domains—from structure to function. Cell 71, 359–362.

    Article  PubMed  CAS  Google Scholar 

  • Ren, R.B., Mayer, B.J., Cicchetti, P., Baltimore, D. (1993). Identification of a 10-amino acid proline-rich sH3 binding-site. Science 259, 1157–1161.

    Article  PubMed  CAS  Google Scholar 

  • Sampson, J.R., Harris, P.C. (1994). The molecular-genetics of tuberous sclerosis. Hum. Mol. Genet. 3, 1477–1480.

    PubMed  CAS  Google Scholar 

  • Xu, L., Sterner, C., Maheshwar, M.M., Wilson, P.J., Neilist, M., Short, P.M., Haines, J.L., Sampson, J.R., Ramesh, V. (1995). Alternative splicing of the tuberous sclerosis-2 (tsc2) gene in human and mouse-tissues. Genomics 27, 475–480.

    Article  PubMed  CAS  Google Scholar 

  • Yeung, R.S., Xiao, G.H., Jin, F., Lee, W.C., Testa, J.R., Knudson, A.G. (1994). Predisposition to renal-carcinoma in the Eker rat is determined by germ-line mutation of the tuberous-sclerosis-2 (tsc2) gene. Proc. Natl. Acad. Sci. USA 91, 11413–11416.

    Article  PubMed  CAS  Google Scholar 

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Olsson, P.G., Schofield, J.N., Edwards, Y.H. et al. Expression and differential splicing of the mouse TSC2 homolog. Mammalian Genome 7, 212–215 (1996). https://doi.org/10.1007/s003359900057

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