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QTL for the heritable inverted teat defect in pigs

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Abstract

The mothering ability of a sow largely depends on the shape and function of the mammary gland. The aim of this study was to identify QTL for the heritable inverted teat defect, a condition characterized by disturbed development of functional teats. A QTL analysis was conducted in a porcine experimental population based on Duroc and Berlin Miniature pigs (DUMI). The significant QTL were confirmed by linkage analysis in commercial pigs according to the affected sib pair design and refined by family-based association test (FBAT). Nonparametric linkage (NPL) analysis revealed five significant and seven suggestive QTL for the inverted teat defect in the porcine experimental population. In commercial dam lines five significant NPL values were detected. QTL regions in overlapping marker intervals or close proximity in both populations were found on SSC3, SSC4, SSC6, and SSC11. SSC6 revealed QTL in both populations at different positions, indicating the segregation of at least two QTL. The results confirm the previously proposed polygenic inheritance of the inverted teat defect and, for the first time, point to genomic regions harboring relevant genes. The investigation revealed variation of the importance of QTL in the various populations due to either differences in allele frequencies and statistical power or differences in the genetic background that modulates the impact of the liability loci on the expression of the disease. The QTL study enabled us to name a number of plausible positional candidate genes. The correspondence of QTL regions for the inverted teat defect and previously mapped QTL for teat number are in line with the etiologic relationship of these traits.

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Acknowledgments

This work was supported by funds provided by the Development Association for Biotechnology Research (FBF) and the Research Federal Ministry of Education and Research (BMBF).

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Authors and Affiliations

  1. Institute of Animal Breeding Science, University of Bonn, Endenicher Allee 15, 53115, Bonn, Germany

    Elisabeth Jonas, Heinz-Josef Schreinemachers, Tina Kleinwächter, Cemal Ün, Ina Oltmanns, Danyel Jennen, Dawid Tesfaye, Heinz Juengst, Ernst Tholen & Karl Schellander

  2. Research Institute for the Biology of Farm Animals (FBN), Wilhelm-Stahl-Allee 2, 18196, Dummerstorf, Germany

    Sylvio Tetzlaff, Siriluck Ponsuksili, Eduard Murani & Klaus Wimmers

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  1. Elisabeth Jonas
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  2. Heinz-Josef Schreinemachers
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Correspondence to Klaus Wimmers.

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Jonas, E., Schreinemachers, HJ., Kleinwächter, T. et al. QTL for the heritable inverted teat defect in pigs. Mamm Genome 19, 127–138 (2008). https://doi.org/10.1007/s00335-007-9086-5

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