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Assessment of microvessel perfusion of pituitary adenomas: a feasibility study using turbo spin-echo-based intravoxel incoherent motion imaging

  • Magnetic Resonance
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Objectives

To evaluate the feasibility of assessment of microvessel perfusion of pituitary adenomas with intravoxel incoherent motion (IVIM) imaging using single-shot turbo spin-echo-based diffusion-weighted imaging (SS-TSE-DWI).

Methods

We examined 51 consecutive patients with pituitary adenomas (35 non-functioning and 16 functioning) and 32 patients with normal pituitary glands using SS-TSE-DWI IVIM. The diffusion coefficient (D), the perfusion fraction (f), and the pseudo-diffusion coefficient (D*) were calculated pixel-by-pixel for each adenoma and normal pituitary gland. We also obtained the pathological microvessel area (MVA) of each adenoma. The IVIM parameters in adenomas were compared with those in normal pituitary glands using the Mann–Whitney U test. The correlation between the MVA and IVIM f of adenomas was analyzed using Spearman’s rank correlation coefficient.

Results

The mean D (× 10−3 mm2/s) in adenomas was 0.723 ± 0.253, which was significantly lower than that in normal pituitary glands (0.862 ± 0.128; p < 0.0001). The mean f (%) in adenomas was 10.74 ± 4.51, which was significantly lower than that in normal pituitary glands (13.26 ± 4.32, p = 0.0251). No significant difference was found in the mean D*. We found a significant positive correlation between MVA and f in non-functioning adenomas (ρ = 0.634, p < 0.0001) as well as in all adenomas (ρ = 0.451, p = 0.0009).

Conclusions

Assessment of microvessel perfusion of pituitary adenomas based on SS-TSE-DWI IVIM is feasible. Compared to normal pituitary glands, pituitary adenomas were characterized by lower D and f.

Key Points

• Assessment of microvessel perfusion of pituitary adenomas based on SS-TSE-IVIM is feasible.

• SS-TSE-IVIM helps with evaluation of the vascularity of pituitary lesions.

• Pituitary adenomas were characterized by lower D and f than normal pituitary glands.

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Abbreviations

ACTH:

Adrenocorticotropic hormone

ADC:

Apparent diffusion coefficient

ASL:

Arterial spin labeling

D :

True diffusion coefficient

D*:

Pseudo-diffusion coefficient

EPI:

Echo-planar image

f :

Perfusion fraction

FOV:

Field of view

GH:

Growth hormone

ICC:

Intraclass correlation coefficient

MVA:

Microvessel area

MVD:

Microvessel density

PRL:

Prolactin

SI:

Signal intensity

SI0 :

Signal intensity at a given b = 0 s/mm2

SS:

Single shot

TE:

Echo time

TFE:

Turbo field-echo

TR:

Repetition time

TSE:

Turbo spin-echo

TSH:

Thyroid-stimulating hormone

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Acknowledgments

The authors would like to thank Tomoko Takajo (technical assistant) who helped with the immunohistochemical staining for CD34 to obtain microvessel densities and areas of pituitary adenomas. This retrospective study was approved by the Kagoshima University Hospital Ethical Committee (reference: Epidemiology 170123-revision 1).

Funding

The authors state that this work has not received any funding.

Author information

Authors and Affiliations

  1. Department of Radiology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Kiyohisa Kamimura, Masanori Nakajo, Tomohide Yoneyama, Yoshihiko Fukukura & Takashi Yoshiura

  2. Department of Neurosurgery, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Shingo Fujio

  3. Department of Pathology, Graduate School of Medical and Dental Sciences, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Yuko Goto

  4. Department of Radiological Technology, Kagoshima University Hospital, 8-35-1 Sakuragaoka, Kagoshima, 890-8544, Japan

    Takashi Iwanaga

  5. Philips Japan, 13-37, Kohnan 2-chome Minato-ku, Tokyo, 108-8507, Japan

    Yuta Akamine

Authors
  1. Kiyohisa Kamimura
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  2. Masanori Nakajo
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  3. Tomohide Yoneyama
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  4. Yoshihiko Fukukura
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  5. Shingo Fujio
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  6. Yuko Goto
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  7. Takashi Iwanaga
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  8. Yuta Akamine
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  9. Takashi Yoshiura
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Corresponding author

Correspondence to Takashi Yoshiura.

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Guarantor

The scientific guarantor of this publication is Takashi Yoshiura.

Conflict of interest

The authors of this manuscript declare relationships with Philips Japan. Yuta Akamine is an employee of Philips Japan.

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No complex statistical methods were necessary for this paper.

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Written informed consent was waived by the institutional review board.

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Institutional review board approval was obtained.

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• retrospective

• diagnostic study

• performed at one institution

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Kamimura, K., Nakajo, M., Yoneyama, T. et al. Assessment of microvessel perfusion of pituitary adenomas: a feasibility study using turbo spin-echo-based intravoxel incoherent motion imaging. Eur Radiol 30, 1908–1917 (2020). https://doi.org/10.1007/s00330-019-06443-x

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  • DOI: https://doi.org/10.1007/s00330-019-06443-x

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