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Autosomal dominant polycystic kidney disease: new role for ultrasound

  • Ultrasound
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Abstract

Objectives

To evaluate the accuracy of US in calculating renal volumes and renal resistive index (RRI) that was obtained using a new method in patients with autosomal dominant polycystic kidney disease (ADPKD).

Methods

In this prospective study, US and MRI were performed in 57 patients with ADPKD (31 female and 26 male; age range, 19–79 years) between August 2017 and May 2018. The volumes determined using US and MRI were compared. The ellipsoid formula was re-evaluated using different multipliers. RRI was obtained 1.5–2 cm distal to the outlet of main renal arteries. The relationship between mean RRI, renal function tests, and kidney volumes and difference between mean RRI of ADPKD patients with and without renal failure were investigated using a two-sided independent samples t test and Pearson correlation test. Interobserver agreements for volume assessments and RRI measurements were determined.

Results

By changing the ellipsoid formula, a very good agreement was found (ICC 0.970 for the right kidney and ICC 0.973 for the left kidney). The mean RRI in the right renal artery was 0.61 ± 0.07 and in the left renal artery 0.63 ± 0.06. The mean RRI of ADPKD patients with renal failure was significantly higher than that of patients without renal failure (p = 0.005). There was a significant correlation between mean RRI and renal function tests.

Conclusion

The accuracy of the US in calculating renal volumes increases by adapting the ellipsoid formula. RRI may be used for the management of ADPKD independently of volumes.

Key Points

•The accuracy of ultrasonography for renal volume measurement increases by changing the classical ellipsoid formula.

•Renal resistive index measured by color Doppler ultrasonography is helpful for the management of autosomal dominant polycystic kidney disease.

•The role of Doppler US in autosomal dominant polycystic kidney disease should increase as a result of our findings.

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Abbreviations

ADPKD:

Autosomal dominant polycystic kidney disease

AP:

Maximum anteroposterior distance

BUN:

Blood urea nitrogen

CCC:

Concordance correlation coefficient

eGFR:

Estimated glomerular filtration rate

H:

Maximum renal height

ICC:

Intraclass correlation coefficient

ML:

Maximum mediolateral distance

MRI:

Magnetic resonance imaging

RRI:

Renal resistive index

TKV:

Total kidney volume

US:

Ultrasound

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Funding

The authors state that this work has not received any funding.

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Authors and Affiliations

  1. Department of Radiology, Erciyes University Medical Faculty, 38039, Kayseri, Turkey

    Hakan İmamoğlu, Serap Doğan & Nuri Erdoğan

  2. Department of Biostatistics, Erciyes University Medical Faculty, Kayseri, Turkey

    Gökmen Zararsız & Ahmet Öztürk

  3. Turcosa Analytics Solutions Ltd Co, Kayseri, Turkey

    Gökmen Zararsız & Ahmet Öztürk

  4. Department of Nephrology, Erciyes University Medical Faculty, Kayseri, Turkey

    İsmail Koçyiğit & Eray Eroğlu

Authors
  1. Hakan İmamoğlu
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  2. Gökmen Zararsız
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  3. Serap Doğan
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  4. İsmail Koçyiğit
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  5. Eray Eroğlu
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  6. Ahmet Öztürk
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  7. Nuri Erdoğan
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Corresponding author

Correspondence to Hakan İmamoğlu.

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Guarantor

The scientific guarantor of this publication is Hakan İmamoğlu.

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Statistics and biometry

Two of the authors have significant statistical expertise.

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Written informed consent was obtained from all subjects (patients) in this study.

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Institutional Review Board approval was obtained.

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• prospective

• diagnostic or prognostic study

• performed at one institution

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İmamoğlu, H., Zararsız, G., Doğan, S. et al. Autosomal dominant polycystic kidney disease: new role for ultrasound. Eur Radiol 29, 5991–5998 (2019). https://doi.org/10.1007/s00330-019-06238-0

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  • DOI: https://doi.org/10.1007/s00330-019-06238-0

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