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One-stop shop assessment for atrial septal defect closure using 256-slice coronary CT angiography

  • Cardiac
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Abstract

Objectives

To investigate the feasibility and accuracy of measurement of the pulmonary to systemic blood flow ratio (Qp/Qs) and defect and rim sizes in secundum atrial septal defects (ASDs) using 256-slice CT, compared to the reference transoesophageal echocardiography (TEE) and right heart catheterization (RHC) measurements.

Methods

Twenty-three consecutive adult patients with secundum ASDs who underwent retrospective ECG-gated coronary CT angiography (CCTA), TEE and RHC were enrolled in this study. Right ventricular (RV) and left ventricular (LV) stroke volumes (SV) were calculated by biventricular volumetry of CCTA. Qp/Qs-CT was defined as RVSV/LVSV. The sizes of the defect and rim were measured by multi-planar reconstruction CT images. Correlations between Qp/Qs-CT and Qp/Qs–RHC and between the defect diameter obtained by CT and TEE were analyzed by Pearson’s coefficient analysis. Rim sizes by CT and TEE were compared by paired t-test.

Results

Qp/Qs-CT was significantly correlated with Qp/Qs-RHC (r = 0.83, p < 0.0001), and the defect diameter by CT was significantly correlated with that by TEE (r = 0.95, p < 0.0001). There was no significant difference between CT and TEE in measurements of rim size.

Conclusions

256-slice CCTA allows measuring Qp/Qs and size of defects and rims in patients with secundum ASDs, accomplishing pretreatment evaluation non-invasively and comprehensively.

Key Points

• Quantification of left-to-right shunting can be performed reliably and accurately by CT.

• The sizes of defects and rims can be measured accurately using 256-slice CT.

• 256-slice CT permits pretreatment evaluation of ASD non-invasively and comprehensively.

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Acknowledgements

The scientific guarantor of this publication is Hiroshi Honda. The authors of this manuscript declare relationships with the following companies: Nagao M. and Kawanami S: Bayer Healthcare Japan, Modest, Research Grant; Philips Electronics Japan, Modest, Research Grant

This study has received funding from the Japan Society for the Promotion of Science (JSPS) KAKENHI (25461831). No complex statistical methods were necessary for this paper.

Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. Methodology: prospective, diagnostic study, performed at one institution.

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Authors and Affiliations

  1. Department of Clinical Radiology, Graduate School of Medical Sciences, Kyushu University, 3-1-1 Maidashi, Higashi-ku, Fukuoka, 812-8582, Japan

    Yuzo Yamasaki, Takeshi Kamitani, Koji Sagiyama, Torahiko Yamanouchi & Hiroshi Honda

  2. Department of Molecular Imaging and Diagnosis, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Michinobu Nagao & Satoshi Kawanami

  3. Department of Cardiovascular Medicine, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Ichiro Sakamoto

  4. Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Kenichiro Yamamura

  5. Department of Health Sciences, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan

    Hidetake Yabuuchi

Authors
  1. Yuzo Yamasaki
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  2. Michinobu Nagao
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  3. Satoshi Kawanami
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  4. Takeshi Kamitani
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  5. Koji Sagiyama
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  6. Torahiko Yamanouchi
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  7. Ichiro Sakamoto
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  8. Kenichiro Yamamura
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  9. Hidetake Yabuuchi
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  10. Hiroshi Honda
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Corresponding author

Correspondence to Yuzo Yamasaki.

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Yamasaki, Y., Nagao, M., Kawanami, S. et al. One-stop shop assessment for atrial septal defect closure using 256-slice coronary CT angiography. Eur Radiol 27, 697–704 (2017). https://doi.org/10.1007/s00330-016-4407-2

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  • DOI: https://doi.org/10.1007/s00330-016-4407-2

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