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Late gadolinium enhancement cardiac imaging on a 3T scanner with parallel RF transmission technique: prospective comparison of 3D-PSIR and 3D-IR

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Abstract

Objective

To qualitatively and quantitatively compare different late gadolinium enhancement (LGE) sequences acquired at 3T with a parallel RF transmission technique.

Methods

One hundred and sixty participants prospectively enrolled underwent a 3T cardiac MRI with 3 different LGE sequences: 3D Phase-Sensitive Inversion-Recovery (3D-PSIR) acquired 5 minutes after injection, 3D Inversion-Recovery (3D-IR) at 9 minutes and 3D-PSIR at 13 minutes. All LGE-positive patients were qualitatively evaluated both independently and blindly by two radiologists using a 4-level scale, and quantitatively assessed with measurement of contrast-to-noise ratio and LGE maximal surface. Statistical analyses were calculated under a Bayesian paradigm using MCMC methods.

Results

Fifty patients (70 % men, 56yo ± 19) exhibited LGE (62 % were post-ischemic, 30 % related to cardiomyopathy and 8 % post-myocarditis). Early and late 3D-PSIR were superior to 3D-IR sequences (global quality, estimated coefficient IR > early-PSIR : -2.37 CI = [-3.46 ; -1.38], prob(coef > 0) = 0 % and late-PSIR > IR : 3.12 CI = [0.62 ; 4.41], prob(coef > 0) = 100 %), LGE surface estimated coefficient IR > early-PSIR: -0.09 CI = [-1.11; -0.74], prob(coef > 0) = 0 % and late-PSIR > IR : 0.96 CI = [0.77; 1.15], prob(coef > 0) = 100 %). Probabilities for late PSIR being superior to early PSIR concerning global quality and CNR were over 90 %, regardless of the aetiological subgroup.

Conclusions

In 3T cardiac MRI acquired with parallel RF transmission technique, 3D-PSIR is qualitatively and quantitatively superior to 3D-IR.

Key Points

• Late gadolinium enhancement is an essential part of a cardiac MRI examination

• PSIR and IR sequences are the two possible options for LGE imaging

• At 3T with parallel RF transmission, PSIR sequences are significantly better

• One LGE sequence is sufficient, allowing an optimization of the acquisition time

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Abbreviations

CAD:

Coronary artery disease

CMR:

Cardiac magnetic resonance

CNR:

Contrast to noise ratio

LGE:

Late Gadolinium enhancement

RF:

Radiofrequency

TI:

Inversion time

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Acknowledgments

The scientific guarantor of this publication is Pr. Catherine Roy. The authors of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article. The authors state that this work has not received any funding. One of the authors is a biostatistician: Dr. Mickaël Schaeffer. Institutional Review Board approval was obtained. Written informed consent was obtained from all subjects (patients) in this study. No study subjects or cohorts have been previously reported. Methodology: prospective, observational, performed at one institution.

Conflicts of interest

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Author information

Authors and Affiliations

  1. Radiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg Cedex, France

    Anthony Schultz, Aïssam Labani, Mi-Young Jeung, Soraya El Ghannudi, Catherine Roy & Mickaël Ohana

  2. Cardiology Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg Cedex, France

    Thibault Caspar

  3. Public Health and Biostatistics Department, Nouvel Hôpital Civil, Strasbourg University Hospital, Strasbourg Cedex, France

    Mickaël Schaeffer

  4. iCube Laboratory, Université de Strasbourg / CNRS, UMR 7357, 67400, Illkirch, France

    Mickaël Ohana

  5. Service de Radiologie, Nouvel Hôpital Civil, 1 Place de l’Hôpital, 67091, Strasbourg Cedex, France

    Anthony Schultz

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  1. Anthony Schultz
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Correspondence to Anthony Schultz.

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Schultz, A., Caspar, T., Schaeffer, M. et al. Late gadolinium enhancement cardiac imaging on a 3T scanner with parallel RF transmission technique: prospective comparison of 3D-PSIR and 3D-IR. Eur Radiol 26, 1547–1555 (2016). https://doi.org/10.1007/s00330-015-4002-y

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  • DOI: https://doi.org/10.1007/s00330-015-4002-y

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