Skip to main content
Log in

Patient selection guidelines in MR-guided focused ultrasound surgery of uterine fibroids: a pictorial guide to relevant findings in screening pelvic MRI

  • Urogenital
  • Published:
European Radiology Aims and scope Submit manuscript

Abstract

Uterine leiomyomas (fibroids), the most common benign tumor in women of childbearing age, can cause symptoms including dysmenorrhea, menorrhagia, urinary symptoms, pain and infertility. Hysterectomy is a common approach to treating uterine fibroids, and less invasive surgical approaches such as myomectomy and uterine artery embolization also have been shown to alleviate symptoms. Magnetic resonance-guided focused ultrasound surgery (MRgFUS) is the only totally non-invasive surgical approved method for treating uterine fibroids. In clinical trials, MRgFUS resulted in significant relief of uterine fibroid symptoms. The safe and effective use of MRgFUS is affected by fibroid type and location, position relative to adjacent anatomical structures and the presence of co-existent pelvic disease. Additionally, successful outcomes with MRgFUS have been correlated with the volume of fibroids ablated during the procedure. Thus, selection of patients in whom sufficient fibroid volumes can be treated safely using the MRgFUS system is critical for successful outcomes. The MR images in this pictorial essay provide examples of uterine fibroids for which MRgFUS should be considered and is designed to facilitate the selection of patients for whom MRgFUS is most likely to provide sustained symptom relief.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7
Fig. 8
Fig. 9
Fig. 10

Similar content being viewed by others

References

  1. Buttram VC, Reiter RC (1981) Uterine leiomyomata: etiology, symptomatology, and management. Fertil Steril 36:433–445

    PubMed  Google Scholar 

  2. Cramer SF, Patel A (1990) The frequency of uterine leiomyomas. Am J Clin Pathol 94:435–438

    PubMed  CAS  Google Scholar 

  3. Fennessy FM, Tempany CM (2006) A review of magnetic resonance imaging-guided focused ultrasound surgery of uterine fibroids. Top Magn Reson Imaging 17:173–179

    Article  PubMed  Google Scholar 

  4. Carlson KJ, Nichols DH, Schiff I (1993) Indications for hysterectomy. N Engl J Med 328:856–860

    Article  PubMed  CAS  Google Scholar 

  5. Stewart EA (2001) Uterine fibroids. Lancet 357:293–298

    Article  PubMed  CAS  Google Scholar 

  6. Hesley GK, Felmlee JP, Gebhart JB et al (2006) Noninvasive treatment of uterine fibroids: early Mayo Clinic experience with magnetic resonance imaging-guided focused ultrasound. Mayo Clin Proc 81:936–942

    Article  PubMed  Google Scholar 

  7. Stewart EA, Gostout B, Rabinovici J et al (2007) Sustained relief of leiomyoma symptoms by using focused ultrasound surgery. Obstet Gynecol 110:279–287

    PubMed  Google Scholar 

  8. Stewart EA, Rabinovici J, Tempany CM et al (2006) Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertil Steril 85:22–29

    Article  PubMed  Google Scholar 

  9. Fennessy FM, Stewart EA et al (2007) Uterine leiomyomas: MR imaging-guided focused ultrasound surgery-results of different treatment protocols. Radiology 243(3):885–893

    Article  PubMed  Google Scholar 

  10. Cura M, Cura A, Bugnone A (2006) Role of magnetic resonance imaging in patient selection for uterine artery embolization. Acta Radiol 47:1105–1114

    Article  PubMed  CAS  Google Scholar 

  11. Stewart EA, Gedroyc WM, Tempany CM et al (2003) Focused ultrasound treatment of uterine fibroid tumors: safety and feasibility of a noninvasive thermoablative technique. Am J Obstet Gynecol 189:48–54

    Article  PubMed  Google Scholar 

  12. Stewart EA et al (2006) Clinical outcomes of focused ultrasound surgery for the treatment of uterine fibroids. Fertil Steril 85(1):22–29

    Article  PubMed  Google Scholar 

  13. Smart OC, Hindley JT, Regan L, Gedroyc WG (2006) Gonadotrophin-releasing hormone and magnetic-resonance-guided ultrasound surgery for uterine leiomyomata. Obstet Gynecol 108:49–54

    PubMed  CAS  Google Scholar 

  14. Smart OC, Hindley JT, Regan L, Gedroyc WG (2006) Magnetic resonance guided focused ultrasound surgery of uterine fibroids-the tissue effects of GnRH agonist pre-treatment. Eur J Radiol 59:163–167

    Article  PubMed  CAS  Google Scholar 

  15. Hindley J et al (2004) MRI guidance of focused ultrasound therapy of uterine fibroids: early results. AJR 183:1713–1719

    PubMed  Google Scholar 

  16. Funaki K et al (2007) Mid-term outcome of magnetic resonance-guided focused ultrasound surgery for uterine myomas: from six to twelve months after volume reduction. Journal of Minimally Invasive Gynecology 14:616–621

    Article  PubMed  Google Scholar 

  17. Funaki K et al (2007) Subjective effect of magnetic resonance-guided focused ultrasound surgery for uterine fibroids. J Obstet Gynaecol Res 33(6):834–839

    Article  PubMed  Google Scholar 

  18. Deligdisch L, Hirschmann S, Altchek A (1997) Pathologic changes in gonadotropin releasing hormone agonist analogue treated uterine leiomyomata. Fertil Steril 67:837–841

    Article  PubMed  CAS  Google Scholar 

  19. Tamai K et al (2005) MR Imaging findings of adenomyosis: correlation with histopathologic features and diagnostic pitfalls. Radiographics 25(1):21–40

    Article  PubMed  Google Scholar 

  20. Rabinovici J et al (2006) Pregnancy and live birth after focused ultrasound surgery for symptomatic focal adenomyosis: a case report. Hum Reprod 21(5):1255–1259

    Article  PubMed  CAS  Google Scholar 

  21. Phillips BJ (2002) Quick review: uterine fibroids. The Internet Journal of Gynecology and Obstetrics 1(2)

  22. Samuel A, Stewart EA et al (2007) Avoiding treatment of leiomyosarcomas: the role of magnetic resonance in focused ultrasound surgery. Fertil Steril. doi:10.1016/j.fertnstert.2007.08.019

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Sang-Wook Yoon.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Yoon, SW., Lee, C., Cha, S.H. et al. Patient selection guidelines in MR-guided focused ultrasound surgery of uterine fibroids: a pictorial guide to relevant findings in screening pelvic MRI. Eur Radiol 18, 2997–3006 (2008). https://doi.org/10.1007/s00330-008-1086-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00330-008-1086-7

Keywords

Navigation