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Global left-ventricular function assessment using dual-source multidetector CT: effect of improved temporal resolution on ventricular volume measurement

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Abstract

The purpose was to compare global left-ventricular (LV) function parameters measured with cine MRI with results from multiphase dual-source CT (DSCT) using 10 and 20 reconstruction phases. Twenty-eight patients with suspected or known CAD underwent DSCT coronary angiography. LV end-diastolic (EDV), end-systolic (ESV) and stroke volumes (SV), and ejection fraction (EF) were determined using LV segmentation and selection of specific phases from DSCT image sets reconstructed either at 5% or 10% steps through the R-R interval. Cine MRI served as the reference investigation. Threshold-based 3D-segmentation was feasible in all DSCT data sets. EDV and ESV were underestimated by DSCT, but showed excellent correlation (Pearson’s correlation coefficient 0.95/0.97) to values obtained with MRI. Using data from 5% DSCT image reconstructions instead of 10% phase reconstructions, the position of the ED and ES phase was changed in 16 of 28 patients; ESVs were to found to be slightly smaller, whereas EDV were slightly larger, resulting in a systematic overestimation of LV EF by 1.9% (p = 0.56). Threshold-based 3D segmentation enables accurate and reliable DSCT determination of global LV function with excellent correlation to cine MRI. Minor differences in LV EF indicate that both modalities are virtually interchangeable, even if the number of reconstructed phases is limited to 10% phase reconstructions.

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Acknowledgements

This work was partly supported by grants from the Deutsche Forschungsgemeinschaft (DFG), Sonderforschungsbereich 656 MoBil Münster, Germany (project C2)

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Authors and Affiliations

  1. Department of Clinical Radiology, University Hospital of Muenster, Albert-Schweitzer-Straße 33, 48149, Muenster, Germany

    Michael Puesken, Roman Fischbach, Mirja Wenker, Harald Seifarth, David Maintz, Walter Heindel & Kai Uwe Juergens

  2. Department of Radiology, Asklepios Klinik Altona, Paul Ehrlich-Straße 1, 22763, Hamburg, Germany

    Roman Fischbach

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  1. Michael Puesken
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Correspondence to Kai Uwe Juergens.

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Puesken, M., Fischbach, R., Wenker, M. et al. Global left-ventricular function assessment using dual-source multidetector CT: effect of improved temporal resolution on ventricular volume measurement. Eur Radiol 18, 2087–2094 (2008). https://doi.org/10.1007/s00330-008-0982-1

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  • DOI: https://doi.org/10.1007/s00330-008-0982-1

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