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Accuracy of ultrasound-guided, large-core needle breast biopsy

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Abstract

Ultrasound-guided, large-core needle biopsy (US-LCNB) of suspicious breast lesions is acknowledged as less invasive and less expensive and less time consuming than surgical biopsy, and provides a histologic diagnosis with a comparable high degree. US-LCNB has been proven to help reduce the number of unnecessary surgeries for benign disease. Its limitations, however, are false-negative results and underestimation of disease. Thus, the demand for breast teams is to carefully adhere to the principles of triple assessment and imaging-histologic correlation, and follow-up of lesions with a specific benign histology after biopsy. Also, the acceptance of guidelines and rigorous quality controls help to reliably minimize the delay in the diagnosis of breast cancer in patients with false-negative biopsies. This paper aims to summarize the equipment and methods as well as the benefits and limitations of US-LCNB. Also, guidelines of quality assessment are suggested. Finally, recent developments which may help to overcome the limitations of US-LCNB will be discussed, i.e., directional vacuum-assisted biopsy (VAB), three-dimensional (3D) US-guided biopsy, as well as the use of tissue harmonic imaging (THI) and compound imaging (CI) during biopsy.

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Acknowledgements

We are grateful to Mary McAllister, Johns Hopkins University Hospital, Baltimore, Md., USA, for manuscript assistance.

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Authors and Affiliations

  1. Department of Radiology, Medical University of Vienna, Waehringer Guertel 18-20, 1090, Vienna, Austria

    G. Schueller, C. Schueller-Weidekamm & T. H. Helbich

  2. Department of Medical Imaging, University of Toronto, Princess Margaret Hospital, 610 University Avenue, Toronto, Ontario, Canada, M5G 2M9

    T. H. Helbich

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  1. G. Schueller
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Schueller, G., Schueller-Weidekamm, C. & Helbich, T.H. Accuracy of ultrasound-guided, large-core needle breast biopsy. Eur Radiol 18, 1761–1773 (2008). https://doi.org/10.1007/s00330-008-0955-4

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