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Endovascular gamma irradiation for the prevention restenosis after angioplasty of femoropopliteal de novo stenoses

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Abstract

The purpose of this study was to investigate the effectiveness and detect side effects of centered, overlapped endovascular gamma irradiation after angioplasty of de novo femoropopliteal stenoses. Thirty patients (age 65.3±9.2 years) with arterial occlusive disease were prospectively enrolled to receive endovascular gamma irradiation (192-iridium, 14 Gy centered at 2 mm vessel wall) immediately after percutaneous transluminal angioplasty (PTA) of femoropopliteal stenoses. Irradiation overlapped dilatation by 1–2 cm at each end. Follow-up involved angiography after 12 months; duplex sonography; and interviews before and after PTA and at 1, 6, and 12 months follow-up. PTA and centered endovascular irradiation were performed successfully in all patients. Three thromboembolic complications occurred during irradiation. Angiographic and clinical follow-up was possible in 28 patients. The angiographic degree of stenosis was 73.8%±16.3% before and 3.6%±23.5% after PTA and was 3.5%±43.7% at the 1-year follow-up. Restenosis (>50%) of the target lesion developed in three patients (10.7%) and edge stenoses (>30%) in nine patients (32.1%). An aneurysm of the irradiated segment in one patient was treated by stenting. The rate of retreatment was 17.9%. The vessel diameter after endovascular gamma irradiation and PTA of femoropopliteal stenoses remained stable. Restenosis, induction of edge stenoses, and aneurysm were reasons for reinterventions.

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Authors and Affiliations

  1. Department of Radiology, University of Cologne, Joseph-Stelzmann-Str., 50924, Cologne, Germany

    Karsten Krueger, Markus Zaehringer, David Strohe, Christopher Bangard & Klaus Lackner

  2. Department of Radiooncology, University of Cologne, Joseph-Stelzmann-Str., 50924, Cologne, Germany

    Mark Bendel, Carsten Weise & Rolf-Peter Mueller

Authors
  1. Karsten Krueger
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  2. Mark Bendel
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  3. Markus Zaehringer
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  4. David Strohe
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  5. Christopher Bangard
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  6. Carsten Weise
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  7. Rolf-Peter Mueller
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  8. Klaus Lackner
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Correspondence to Karsten Krueger.

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Krueger, K., Bendel, M., Zaehringer, M. et al. Endovascular gamma irradiation for the prevention restenosis after angioplasty of femoropopliteal de novo stenoses. Eur Radiol 16, 399–406 (2006). https://doi.org/10.1007/s00330-005-2883-x

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  • DOI: https://doi.org/10.1007/s00330-005-2883-x

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