Abstract
Patients with rheumatoid arthritis (RA) have a high risk for comorbid conditions which increase mortality, hospital admissions, costs of care and inability. To evaluate the prevalence of comorbidities in Mexican mestizo patients with RA and determine the associated risk factors. Cross-sectional study in which RA patients admitted to our outpatient clinic were consecutively enrolled. We collected data regarding demographics, disease characteristics and comorbidities at the time of the patient’s visit to the clinic. We analyzed 225 patients. Their mean age was 55.7 ± 8.3 years; disease duration, 9.5 (3.8–15.5) years; female gender, 93.8%; Disease Activity Score using 28 joints-C-reactive protein, 3 (2–4); methotrexate use, 84.9%; use of any other conventional disease modifying anti-rheumatic drug, 65.7%; use of biological agents, 8%. The most frequently associated diseases were: hypertension, 29.8%; dyslipidemia, 27.1%; osteoporosis, 19.1%; diabetes, 12.4%; hypothyroidism, 6.2%; solid malignancies 4.4%. Risk factors were also evaluated, the most prevalent was overweight in 101 (44.9%) of our patients. A total of 71 (31.6%) had obesity. We also detected high blood pressure in 12.4%, hyperglycemia in 27.1% and hyperlipidemia in 49.8%. Due to the high frequency of comorbidities among RA patients, it is important to follow existing recommendations for their timely detection and management. Cardiovascular diseases must be evaluated with priority. The initial evaluation should include a thorough examination to prevent the deleterious effect of comorbidities in RA.
References
You S, Cho CS, Lee I, Hood L, Hwang D, Kim WU (2012) A systems approach to rheumatoid arthritis. PLoS One 7(12):e51508. doi:10.1371/journal.pone.0051508
Gibofsky A (2012) Overview of epidemiology, pathophysiology, and diagnosis of rheumatoid arthritis. Am J Manag Care 18(13 Suppl):S295–S302
Myasoedova E, Davis JM 3rd, Crowson CS, Gabriel SE (2010) Epidemiology of rheumatoid arthritis: rheumatoid arthritis and mortality. Curr Rheumatol Rep 12(5):379–385. doi:10.1007/s11926-010-0117-y
Pelaez-Ballestas I, Sanin LH, Moreno-Montoya J, Alvarez-Nemegyei J, Burgos-Vargas R, Garza-Elizondo M, Rodriguez-Amado J, Goycochea-Robles MV, Madariaga M, Zamudio J, Santana N, Cardiel MH (2011) Epidemiology of the rheumatic diseases in Mexico. A study of 5 regions based on the COPCORD methodology. J Rheumatol Suppl 86:3–8. doi:10.3899/jrheum.100951
Wolfe F, Michaud K (2008) The risk of myocardial infarction and pharmacologic and nonpharmacologic myocardial infarction predictors in rheumatoid arthritis: a cohort and nested case-control analysis. Arthritis Rheum 58(9):2612–2621. doi:10.1002/art.23811
Michaud K, Wolfe F (2007) Comorbidities in rheumatoid arthritis. Best Pract Res Clin Rheumatol 21(5):885–906. doi:10.1016/j.berh.2007.06.002
Gabriel SE, Michaud K (2009) Epidemiological studies in incidence, prevalence, mortality, and comorbidity of the rheumatic diseases. Arthritis Res Ther 11(3):229. doi:10.1186/ar2669
Chandrashekara S, India CRaICB, Shobha V, India SJsMCHB, Dharmanand BG, India SHB, Jois R, India KDCB, Kumar S, India CAHB, Mahendranath KM, India SHCB, Haridas V, India ASCH, Prasad S, India VHPLM, Singh Y, India MHMK, Daware MA, India NHCMK, Swamy A, India ACMK, Subramanian R, India JMCMK, Somashekar SA, India BRCB, Shanthappa AM, India ARCT, Anupama KR, India CRaICB (2017) Factors influencing remission in rheumatoid arthritis patients: results from Karnataka rheumatoid arthritis comorbidity (KRAC) study. Int J Rheum Dis doi:10.1111/1756-185X.12908
Baillet A, Gossec L, Carmona L, Wit M, van Eijk-Hustings Y, Bertheussen H, Alison K, Toft M, Kouloumas M, Ferreira RJ, Oliver S, Rubbert-Roth A, van Assen S, Dixon WG, Finckh A, Zink A, Kremer J, Kvien TK, Nurmohamed M, van der Heijde D, Dougados M (2016) Points to consider for reporting, screening for and preventing selected comorbidities in chronic inflammatory rheumatic diseases in daily practice: a EULAR initiative. Ann Rheum Dis 75(6):965–973. doi:10.1136/annrheumdis-2016-209233
Hernández-Ávila M, Rivera-Dommarco J, Shamah-Levy L, Gómez-Acosta LM, Gaona-Pineda EB (2016) Encuesta Nacional de Salud y Nutrición 2016: Resultados Nacionales. Instituto Nacional de Salud Pública 2016, Cuernavaca, México
Dougados M, Soubrier M, Antunez A, Balint P, Balsa A, Buch MH, Casado G, Detert J, El-Zorkany B, Emery P, Hajjaj-Hassouni N, Harigai M, Luo SF, Kurucz R, Maciel G, Mola EM, Montecucco CM, McInnes I, Radner H, Smolen JS, Song YW, Vonkeman HE, Winthrop K, Kay J (2014) Prevalence of comorbidities in rheumatoid arthritis and evaluation of their monitoring: results of an international, cross-sectional study (COMORA). Ann Rheum Dis 73(1):62–68. doi:10.1136/annrheumdis-2013-204223
Sarmiento-Monroy JC, Amaya-Amaya J, Espinosa-Serna JS, Herrera-Diaz C, Anaya JM, Rojas-Villarraga A (2012) Cardiovascular disease in rheumatoid arthritis: a systematic literature review in Latin America. Arthritis 2012:371909. doi:10.1155/2012/371909
Solomon DH, Love TJ, Canning C, Schneeweiss S (2010) Risk of diabetes among patients with rheumatoid arthritis, psoriatic arthritis and psoriasis. Ann Rheum Dis 69(12):2114–2117. doi:10.1136/ard.2009.125476
Gremese E, Ferraccioli G (2011) The metabolic syndrome: the crossroads between rheumatoid arthritis and cardiovascular risk. Autoimmun Rev 10(10):582–589. doi:10.1016/j.autrev.2011.04.018
Avouac J, Amrouche F, Meune C, Rey G, Kahan A, Allanore Y (2016) Mortality profile of patients with rheumatoid arthritis in France and its change in 10 years. Semin Arthritis Rheum. doi:10.1016/j.semarthrit.2016.10.007
Solomon DH, Curhan GC, Rimm EB, Cannuscio CC, Karlson EW (2004) Cardiovascular risk factors in women with and without rheumatoid arthritis. Arthritis Rheum 50(11):3444–3449. doi:10.1002/art.20636
Garip Y, Eser F, Bodur H (2016) Comorbidities in Turkish patients with rheumatoid arthritis: association with the health-related quality of life in terms of disease activity, functional and radiological status, severity of pain, and social and emotional functioning. Acta Reumatol Port 41(4):344–349
Carlos F, Clark P, Galindo-Suarez RM, Chico-Barba LG (2013) Health care costs of osteopenia, osteoporosis, and fragility fractures in Mexico. Arch Osteoporos 8:125. doi:10.1007/s11657-013-0125-4
Widdifield J, Ivers NM, Bernatsky S, Jaakkimainen RL, Bombardier C, Thorne JC, Ahluwalia V, Paterson JM, Young J, Wing L, Tu K (2016) Primary care screening and management of comorbidity in rheumatoid arthritis in Ontario, Canada. Arthritis Care Res (Hoboken). doi:10.1002/acr.23178
Caplan A, Fett N, Rosenbach M, Werth VP, Micheletti RG (2017) Prevention and management of glucocorticoid-induced side effects: a comprehensive review: a review of glucocorticoid pharmacology and bone health. J Am Acad Dermatol 76(1):1–9. doi:10.1016/j.jaad.2016.01.062
Firestein G, Gabriel S, McInnes I, O’Dell J (2017) Kelley and Firestein’s textbook of rheumatology, 10th edn, Elsevier, Philadeplphia, PA, USA, p 1120
Pelaez I, Infante C, Quintana R (2015) Help-seeking trajectory in patients with rheumatoid arthritis. Clin Rheumatol 34:17–28. doi:10.1007/s10067-015-3013-z
Agca R, Heslinga SC, Rollefstad S, Heslinga M, McInnes IB, Peters MJ, Kvien TK, Dougados M, Radner H, Atzeni F, Primdahl J, Sodergren A, Wallberg Jonsson S, van Rompay J, Zabalan C, Pedersen TR, Jacobsson L, de Vlam K, Gonzalez-Gay MA, Semb AG, Kitas GD, Smulders YM, Szekanecz Z, Sattar N, Symmons DP, Nurmohamed MT (2016) EULAR recommendations for cardiovascular disease risk management in patients with rheumatoid arthritis and other forms of inflammatory joint disorders: 2015/2016 update. Ann Rheum Dis. doi:10.1136/annrheumdis-2016-209775
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All procedures performed in this study were in accordance with the ethical standards of the institutional research committee and with the 1964 Helsinki declaration and its later amendments.
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Galarza-Delgado, D.A., Azpiri-Lopez, J.R., Colunga-Pedraza, I.J. et al. Prevalence of comorbidities in Mexican mestizo patients with rheumatoid arthritis. Rheumatol Int 37, 1507–1511 (2017). https://doi.org/10.1007/s00296-017-3769-3
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DOI: https://doi.org/10.1007/s00296-017-3769-3