Abstract
Behçet’s disease represents a multisystemic inflammatory disease characterized by recurrent oral ulcers, genital ulcers, and uveitis. Although vascular attack and thrombosis are not major complications in Behçet’s disease, they can still pose risks that must not be overlooked. In this paper, we reported that a 25-year-old female Behçet’s disease patient with complete thrombotic obstruction of the inferior vena cava that was successfully treated by aspiration thrombectomy and balloon angioplasty. The procedure produced marked symptomatic improvement. Currently, data about the treatment and the prophylaxis of thrombotic events in Behçet’s disease are lacking. In this case report, we hope to discuss the future direction of such studies, how we understand the mechanism of Behçet’s disease hypercoagulability, and which treatments can improve thrombotic tendencies in Behçet’s disease.
This is a preview of subscription content, log in via an institution to check access.
References
Houman MH, Ben Ghorbel I, Khiari Ben Salah I, Lamloum M, Ben Ahmed M, Miled M (2001) Deep vein thrombosis in Behçet’s disease. Clin Exp Rheumatol 19(5 Suppl 24):S48–S50
Ceylan N, Bayraktaroglu S, Erturk SM, Savas R, Alper H (2010) Pulmonary and vascular manifestations of Behcet disease: imaging findings. AJR Am J Roentgenol 194(2):W158–W164
Bang D, Yoon KH, Chung HG, Choi EH, Lee ES, Lee S (1997) Epidemiological and clinical features of Behçet’s disease in Korea. Yonsei Med J 38(6):428–436
Koc Y, Gullu I, Akpek G, Akpolat T, Kansu E, Kiraz S et al (1992) Vascular involvement in Behçet’s disease. J Rheumatol 19(3):402–410
Kirali K, Civelek A, Daglar B, Sismanoglu M, Akinci E, Berki T et al (1998) An uncommon complication of Behçet’s disease: intracardiac thrombosis needing surgical treatment. Thorac Cardiovasc Surg 46(2):102–105
Radke PW, Schwarz ER, Groesdonk H, Graf J, Janssens U (2001) Thrombosis in Behçet’s disease: report of a case followed by a systematic review using the methodology of evidence-based medicine. J Thromb Thrombolysis 11(2):137–141
Hatemi G, Silman A, Bang D, Bodaghi B, Chamberlain AM, Gul A et al (2008) EULAR recommendations for the management of Behcet disease. Ann Rheum Dis 67(12):1656–1662
Leiba M, Seligsohn U, Sidi Y, Harats D, Sela BA, Griffin JH et al (2004) Thrombophilic factors are not the leading cause of thrombosis in Behçet’s disease. Ann Rheum Dis 63(11):1445–1449
Leiba M, Sidi Y, Gur H, Leiba A, Ehrenfeld M (2001) Behçet's disease and thrombophilia. Ann Rheum Dis 60(12):1081–1085
Song JS, Park W (1998) A case of Behçet’s disease associated with protein S deficiency. Korean J Med 55(3):427–431
Kwon SR, Lim MJ, Park SG, Moon YS, Park W (2006) Decreased protein S activity is related to the disease activity of Behçet’s disease. Rheumatol Int 27(1):39–43
Guermazi S, Hamza M, Dellagi K (1997) Protein S deficiency and antibodies to protein S in patients with Behçet’s disease. Thromb Res 86(3):197–204
Tohme A, Aoun N, El-Rassi B, Ghayad E (2003) Vascular manifestations of Behçet’s disease. Eighteen cases among 140 patients. Jt Bone Spine 70(5):384–389. http://www.sciencedirect.com/science/article/pii/S1297319X03000769
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Jeong, H., Yoo, Ik., Choi, S. et al. Thrombosis in Behçet’s disease: a Behçet’s disease patient with complete thrombotic obstruction of IVC and both iliac veins and decreased protein S activity. Rheumatol Int 33, 1633–1635 (2013). https://doi.org/10.1007/s00296-011-2308-x
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00296-011-2308-x