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No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus

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Abstract

The objective of this study was to elucidate whether polymorphisms of the interleukin 23 receptor gene (IL23R) are associated with susceptibility to systemic lupus erythematosus (SLE) in a Korean population. We recruited 602 SLE patients and 991 healthy controls. Seven single nucleotide polymorphisms (rs1004819, rs7517847, rs10489629, rs2201841, rs1343151, rs11209032, and rs1495965) were selected for genotyping among previously reported variants used in a genome-wide association study of inflammatory bowel disease. Polymorphic sites were genotyped using the TaqMan assay. The genotype distributions of IL23R polymorphisms and haplotypes were compared between the SLE patients and healthy controls using multiple logistic regression models. None of the IL23R genetic variants differed significantly between SLE patients and healthy controls, which suggests that IL23R polymorphisms play no role in the susceptibility to SLE in the Korean population.

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Acknowledgments

The authors wish to thank Jung-Ah Kim, Young-Hi Lee, and Eun-Kyoung Ju (The Hospital for Rheumatic Diseases, Hanyang University, Seoul, Korea) for assistance with sample preparation and data collection. This work was supported in part by a grant of the Korea Health 21 R&D Project, Ministry of Health and Welfare, Republic of Korea (no. A010252, A080588).

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Authors and Affiliations

  1. Department of Rheumatology, The Hospital for Rheumatic Diseases, Hanyang University, 17 Haengdang-Dong, Seongdong-Gu, Seoul, 133-792, South Korea

    Hee-Sun Kim, Il Kim & Sang-Cheol Bae

  2. Department of Genetic Epidemiology, SNP Genetics, Inc., 1407 14th Floor, Woolim-rall’ey B, Gasan-dong, Geumcheon-gu, Seoul, 153-803, Korea

    Ji On Kim, Joon Seol Bae & Hyoung Doo Shin

  3. Department of Life Science, Sogang University, 1 Shinsu-dong, Mapo-gu, Seoul, 121-742, Korea

    Hyoung Doo Shin

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  1. Hee-Sun Kim
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  2. Il Kim
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Correspondence to Sang-Cheol Bae.

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Kim, HS., Kim, I., Kim, J.O. et al. No association between interleukin 23 receptor gene polymorphisms and systemic lupus erythematosus. Rheumatol Int 30, 33–38 (2009). https://doi.org/10.1007/s00296-009-0893-8

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  • DOI: https://doi.org/10.1007/s00296-009-0893-8

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