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Neue FIGO-Klassifikation des Ovarial-, Tuben und primären Peritonealkarzinoms

New FIGO classification of ovarian, fallopian tube and primary peritoneal cancer

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Zusammenfassung

Aufgrund neuer Erkenntnisse bzgl. Pathogenese und Ergebnissen klinischer Studien zur Prognose des Ovarial-, Tuben- und primären Peritonealkarzinoms hat die FIGO eine neue Klassifikation erarbeitet. Diese ist seit dem 01.01.2014 zur Stadieneinteilung des Ovarial-, Tuben- und primären Peritonealkarzinoms sowie der malignen ovariellen Keimzell- und der potenziell malignen Keimstrangstromatumoren gültig. Wesentliche Änderungen betreffen die Subkategorisierung des Stadiums FIGO IC/T1c, die Unterteilung der regionären Lymphknotenmetastasen anhand ihrer Größe (≤/> 10 mm) sowie der Fernmetastasen. Letztere werden in ein Stadium IVA und IVB unterteilt.

Abstract

During recent years paramount changes have occurred in the pathogenesis of ovarian cancer and recent clinical studies identified new prognostic factors. Consequently, the FIGO has established a new staging system collectively covering carcinomas derived from the ovaries, the fallopian tubes and primary peritoneal cancers as well as malignant ovarian germ cell and sex-cord stromal tumors. The new staging system started on 01 January 2014. Major changes occurred in the FIGO IC/T1c stage with surgical spill (FIGO IC1/T1c1) versus capsule ruptured before surgery or tumor on ovarian or fallopian tube surface (FIGO IC2/T1c2) versus malignant cells in the ascites or peritoneal washings (FIGO IC3/T1c3). The regional lymph node metastases were subcategorised using a cut-off value of 10 mm as the largest dimension of the metastatic deposits. Distant metastases (excluding peritoneal metastases) were substaged as FIGO IVA/M1a in cases of cytologically or histologically proven pleural involvement and as FIGO IVB/M1b in cases of parenchymal metastases and metastases in extra-abdominal organs (including lymph nodes outside the peritoneal cavity and the inguinal lymph nodes).

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Einhaltung ethischer Richtlinien

Interessenkonflikt. A.K. Höhn, J. Einenkel, C. Wittekind, L.-C. Horn geben an, dass kein Interessenkonflikt besteht. Alle angewandten Verfahren stehen im Einklang mit den ethischen Normen der verantwortlichen Kommission für Forschung am Menschen (institutionell und national) und mit der Deklaration von Helsinki von 1975 in der revidierten Fassung von 2008. Alle Patienten wurden erst nach erfolgter Aufklärung und Einwilligung in die Studie eingeschlossen. Soweit der Beitrag personenbezogene Daten enthält, wurde von den Patienten eine zusätzliche Einwilligung nach erfolgter Aufklärung eingeholt. Dieser Beitrag beinhaltet keine Studien an Menschen oder Tieren.

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Authors and Affiliations

  1. Abteilung Mamma-, Gynäko- & Perinatalpathologie, Institut für Pathologie, Department für Diagnostik, Universitätsklinikum Leipzig AöR, Liebigstr. 24, 04103, Leipzig, Deutschland

    A.K. Höhn, C. Wittekind & L.-C. Horn

  2. Gynäkologische Onkologie, Universitätsfrauenklinik Leipzig (Triersches Institut), Zentrum für Frauen- und Kindermedizin, Universitätsklinikum Leipzig, Leipzig, Deutschland

    J. Einenkel

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  1. A.K. Höhn
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  2. J. Einenkel
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  3. C. Wittekind
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  4. L.-C. Horn
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Correspondence to A.K. Höhn.

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Höhn, A., Einenkel, J., Wittekind, C. et al. Neue FIGO-Klassifikation des Ovarial-, Tuben und primären Peritonealkarzinoms. Pathologe 35, 322–326 (2014). https://doi.org/10.1007/s00292-014-1908-0

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  • DOI: https://doi.org/10.1007/s00292-014-1908-0

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