Skip to main content
Log in

Hautadnex- und Speicheldrüsentumoren

Gemeinsamkeiten und Unterschiede ausgewählter Entitäten

  • Schwerpunkt: Orale Pathologie/Pathologien der Speicheldrüsen
  • Published:
Der Pathologe Aims and scope Submit manuscript

Zusammenfassung

Benigne und maligne Hautadnextumoren, insbesondere drüsig differenzierte Neoplasien, weisen teilweise erstaunliche morphologische Ähnlichkeiten zu Speicheldrüsentumoren auf. Andererseits existieren bei einigen Entitäten histologisch und insbesondere klinisch-prognostisch auch deutliche Unterschiede, deren Kenntnis für eine optimale Therapieplanung und Prognosebestimmung sehr wichtig ist. Im Folgenden sollen anhand ausgewählter Entitäten Gemeinsamkeiten und Unterschiede kurz dargestellt und diskutiert werden, wobei im Einzelnen das Zylindrom (vs. membranöse Variante des Basalzelladenoms), das Sebazeom (vs. sebazeöses Adenom), das Syringocystadenoma papilliferum (vs. Sialadenoma papilliferum), das chondroide Syringom (vs. pleomorphes Adenom), das kutane Myoepitheliom (vs. Myoepitheliom der Speicheldrüsen), das maligne kutane Myoepitheliom (vs. malignes Myoepitheliom der Speicheldrüsen), das kutane adenoid-zystische Karzinom (vs. adenoid-zystisches Karzinom der Speicheldrüsen) und das muzinöse ekkrine Karzinom (vs. muzinöses Adenokarzinom der Speicheldrüsen) besprochen werden.

Abstract

Benign and malignant skin adnexal neoplasms, especially glandular lesions, show morphologically striking similarities to salivary gland tumors. On the other hand, histological and clinical differences are evident, and knowledge of their existence is important for adequate treatment and reliable prognostication. In this review similarities and differences of selected entities are briefly described and discussed. The following entities are reviewed: cylindroma (vs. membranous variant of basal cell adenoma), sebaceoma (vs. sebaceous adenoma), syringocystadenoma papilliferum (vs. sialadenoma papilliferum), chondroid syringoma (vs. pleomorphic adenoma), cutaneous myoepithelioma (vs. myoepithelioma of salivary glands), cutaneous malignant myoepithelioma (vs. malignant myoepithelioma of salivary glands), cutaneous adenoid cystic carcinoma (vs. adenoid cystic carcinoma of salivary glands), and mucinous eccrine carcinoma (vs. mucous carcinoma of salivary glands).

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Abb. 1
Abb. 2
Abb. 3
Abb. 4
Abb. 5
Abb. 6
Abb. 7
Abb. 8

Literatur

  1. Alos L, Cardesa A, Bombi JA et al. (1996) Myoepithelial tumors of salivary glands: a clinicopathologic, immunohistochemical, ultrastructural, and flow-cytometric study. Semin Diagn Pathol 13: 138–147

    CAS  PubMed  Google Scholar 

  2. Auclair PL, Ellis GL (1996) Atypical features in salivary gland mixed tumors: their relationship to malignant transformation. Mod Pathol 9: 652–657

    CAS  PubMed  Google Scholar 

  3. Batsakis JG, Luna MA, el-Naggar AK (1991) Basaloid monomorphic adenomas. Ann Otol Rhinol Laryngol 100: 687–690

    CAS  PubMed  Google Scholar 

  4. Cawson RA, Gleeson MJ, Eveson JW (1997) Carcinomas of salivary glands. Pathology and surgery of the salivary glands. ISIS Medical Media, Oxford, pp 117–169

  5. Chang SE, Ahn SJ, Choi JH et al. (1999) Primary adenoid cystic carcinoma of the skin with lung metastasis. J Am Acad Dermatol 40: 640–642

    CAS  PubMed  Google Scholar 

  6. Eckert F, Schmid U, Hardmeier T, Altmannsberger M (1992) Cytokeratin expression in mucinous sweat gland carcinomas: an immunohistochemical analysis of four cases. Histopathology 21: 161–165

    CAS  PubMed  Google Scholar 

  7. Fernandez-Figueras MT, Puig L, Trias I et al. (1998) Benign myoepithelioma of the skin. Am J Dermatopathol 20: 208–212

    Article  CAS  PubMed  Google Scholar 

  8. Gallimore AP, Spraggs PD, Allen JP, Hobsley M (1994) Basaloid carcinomas of salivary glands. Histopathology 24: 139–144

    CAS  PubMed  Google Scholar 

  9. Gerretsen AL, van der Putte SCJ, Deenstra W, van Vloten WA (1993) Cutaneous cylindroma with malignant transformation. Cancer 72: 1618–1623

    CAS  PubMed  Google Scholar 

  10. Gnepp DR, Brannon R (1984) Sebaceous neoplasms of the salivary gland origin: a review. Pathol Annu 18: 71–102

    Google Scholar 

  11. Hara K (1995) Mixed tumours of the skin: a histological, enzyme-histochemical and immunohistochemical study. Histopathology 25: 145–152

    Google Scholar 

  12. Harrist TJ, Aretz TH, Mihm MC, Evans GW (1981) Cutaneous malignant mixed tumor. Arch Dermatol 117: 719–724

    Article  CAS  PubMed  Google Scholar 

  13. Henriksson G, Westrin KM, Carlsoo B, Silfversward C (1998) Recurrent primary pleomorphic adenomas of salivary gland origin: intrasurgical rupture, histopathologic features, and pseudopodia. Cancer 82: 617–620

    Article  CAS  PubMed  Google Scholar 

  14. Hickman RE, Cawson RA, Duffy SW (1984) The prognosis of specific types of salivary gland tumors. Cancer 54: 1620–1654

    CAS  PubMed  Google Scholar 

  15. Kutzner H, Mentzel T, Kaddu S et al. (2001) Cutaneous myoepithelioma. An underecognized cutaneous neoplasm composed of myoepithelial cells. Am J Surg Pathol 25: 348–355

    CAS  PubMed  Google Scholar 

  16. Laskawi R, Schott T, Schroder M (1998) Recurrent pleomorphic adenomas of the parotid gland: clinical evaluation and long-term follow-up. Br J Oral Maxillofac Surg 36: 48–51

    CAS  PubMed  Google Scholar 

  17. McKee PH (1996) Malignant chondroid syringoma. In Pathology of the skin, 2nd ed. Mosby-Wolfe, London, 15.66

  18. Mentzel T, Requena L, Kaddu S et al. (2003) Cutaneous myoepithelial neoplasms: clinicopathologic and immunohistochemical study of 20 cases suggesting a continuous spectrum ranging from benign mixed tumor of the skin to cutaneous myoepithelioma and myoepithelial carcinoma. J Cutan Pathol 30: 294–302

    Article  PubMed  Google Scholar 

  19. Nagao T, Sugano I, Ishida Y et al. (1998) Salivary gland malignant myoepithelioma: a clinicopathologic and immunohistochemical study of ten cases. Cancer 83: 1292–1299

    Article  CAS  PubMed  Google Scholar 

  20. Nascimento AG, Amaral AL, Prado LA et al. (1986) Adenoid cystic carcinoma of salivary glands. A study of 61 cases with clinicopathologic correlation. Cancer 57: 312–319

    CAS  PubMed  Google Scholar 

  21. Prasad AR, Savera AT, Gown AM, Zarbo RJ (1999) The myoepithelial phenotype in 135 benign and malignant salivary gland tumors other than pleomorphic adenoma. Arch Pathol Lab Med 123: 801–806

    CAS  PubMed  Google Scholar 

  22. Requena L, Kirya H, Ackerman AB (1998) Cribriform carcinoma. The analogous lesion in the breast is cribriform carcinoma. Neoplasms with apocrine differentiation. Lippincott-Raven, pp 879–905

  23. Rütten A, Kutzner H, Hügel H (1994) Das adenoid-zystische Karzinom der Haut. Akt Dermatol 20: 119–121

    Google Scholar 

  24. Santa Cruz DJ (1987) Sweat gland carcinomas: a comprehensive review. Semin Diagn Pathol 4: 38–74

    PubMed  Google Scholar 

  25. Savera AT, Sloman A, Huvos AG, Klimstra DS (2000) Myoepithelial carcinoma of the salivary glands. A clinicopathologic study of 25 patients. Am J Surg Pathol 24: 761–774

    Article  CAS  PubMed  Google Scholar 

  26. Talmi Y, Halpern M, Finkelstein Y et al. (1990) View from beneath: pathology infocus: True malignant mixed tumour of the parotid gland. J Laryngol Otol 104: 360–361

    Google Scholar 

  27. Troy JL, Ackerman AB (1984) Sebaceoma. A distinctive benign neoplasm of adnexal epithelium differentiating toward sebaceous cell. Am J Dermatopathol 6: 7–13

    CAS  PubMed  Google Scholar 

  28. Wick MR, Swanson PE (1986) Primary adenoid cystic carcinoma of the skin. Am J Dermatopathol 8: 2–13

    CAS  PubMed  Google Scholar 

  29. Wick MR, Ockner DM, Mills SE et al. (1998) Homologous carcinomas of the breast, skins, and salivary glands. A histologic and immunohistochemical comparison of ductal mammary carcinoma, ductal sweat gland carcinoma, and salivary duct carcinoma. Am J Clin Pathol 109: 75–84

    CAS  PubMed  Google Scholar 

  30. Wilk M, Klesper D, Uerlich M et al. (1994) Chondroides Syringom. Immunhistologische Hinweise für eine myoepitheliale Differenzierung. Hautarzt 45: 324–329

    Article  CAS  PubMed  Google Scholar 

Download references

Danksagung

Herrn Dr. A. Rütten, Friedrichshafen, sei ganz herzlich für seine wertvollen Hinweise und die Unterstützung bei der Fertigstellung des Manuskriptes gedankt.

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to T. Mentzel.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Mentzel, T. Hautadnex- und Speicheldrüsentumoren. Pathologe 25, 79–88 (2004). https://doi.org/10.1007/s00292-003-0666-1

Download citation

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00292-003-0666-1

Schlüsselwörter

Keywords

Navigation