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Recent advances in carbohydrate-based paclitaxel delivery systems

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Abstract

Paclitaxel (PTX) as the most important member of the taxane family is used against a wide range of cancers including breast, ovarian and lung cancers. However, the effectiveness of PTX in clinical practice is limited by its low water solubility and permeability in biological tissues. To address these limitations, PTX is formulated with Cremophor EL and dehydrated ethanol, known as Taxol®. Due to the adverse side effects of the formulation, efforts have been made in recent years to develop alternative PTX formulations. Polysaccharides, due to their low toxicity and biocompatibility, biodegradability, and ease of chemical modification are an excellent alternative to Cremophor EL for formulating PTX. This review focuses on recent advances to develop PTX formulations based on polysaccharides.

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Reproduced from Ref. [81] with permission from the Royal Society of Chemistry

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Abbreviations

2D:

Two-dimensional

3D:

Three-dimensional

5-FU:

5-Fluorouracil

ACHN:

Alginate coated chitosan hollow nanosphere

ALG:

Alginate

a-OMPC:

O-maleyl-O-phosphoryl chitosan

CD:

Cyclodextrins

CD-DST:

Collagen gel droplet-embedded culture-drug sensitivity test

CMC:

Carboxymethyl chitosan

COL:

Collagen

CPP:

Cell penetrating hybrid

Chitosan-Rhein:

Chitosan-4,5-dihydroxy-9,10-dioxoanthracene-2-carboxylic acid

CRT:

Chemoradiotherapy

CS:

Chitosan

CTAB:

Cetyltrimethylammonium bromide

DL:

Drug loading capacity

DMβCD:

6-Di-O-methyl beta cyclodextrin

DOX:

Doxorubicin

ECM:

Extracellular matrix

EE:

Encapsulation efficiency

EGFR:

Epidermal growth factor receptor

GBM:

Glioblastoma multiforme

HA:

Hydroxyapatite

IDO-1:

2,3-Dioxygenase-1

LMC:

Chitosan-coated liposomal delivery system

LST-Lip:

Losartan loaded liposomes

ND:

Nanodroplet

MH:

Minocycline hydrochloride

MP:

Microparticle

NP:

Nanoparticle

PCL:

Polycaprolactone

P-gp:

P-glycoprotein

PLGA:

Poly(lactic-glycolic acid)

PNIPAAm:

Poly(N-isopropylacrylamide)

PM:

Polymeric micelle

PNP:

Polymeric nanoparticle

PPS:

Paclitaxel loaded into porous starch

PTX:

Paclitaxel

PTXCDL:

Paclitaxel/hydroxypropyl-β-cyclodextrin complex-loaded liposome

SDS:

Sodium dodecyl sulfate

SF:

Silk fibroin

TH-Lip:

AGYLLGHINLHHLAHL(Aib)HHIL-NH2

TJ:

Tight junction

TME:

Tumor microenvironment

TSA:

Thiolated sodium alginate

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Authors and Affiliations

  1. Department of Chemistry, Isfahan University of Technology, Isfahan, 8415683111, Iran

    Azar Ramezanpour

  2. Cellular and Molecular Research Center, Cellular and Molecular Medicine Research Institute, Urmia University of Medical Sciences, Urmia, Iran

    Legha Ansari

  3. Solid Tumor Research Center, Cellular and Molecular Medicine research Institute, Urmia University of Medical Sciences, P.O. Box: 1138, Shafa St, Ershad Blvd, 57147, Urmia, Iran

    Vahid Rahimkhoei, Jafar Rezaie & Ali Akbari

  4. Disruptive Technology Laboratory, Department of Ophthalmology, Massachusetts Eye and Ear and Schepens Eye Research Institute, Harvard Medical School, Boston, MA, USA

    Sina Sharifi

  5. Institute of Polymers, Composites and Biomaterials, National Research Council (IPCB-CNR), Viale J.F. Kennedy 54—Mostra d’Oltremare pad. 20, 80125, Naples, Italy

    Ashkan Bigham

  6. Department of Polymer Processing, Iran Polymer and Petrochemical Institute, Tehran, Iran

    Zohre Mehri Lighvan

  7. Faculty of Chemistry, University of Wrocław, F. Joliot Curie 14, 50383, Wrocław, Poland

    Sławomir Szafert

  8. Polymer Research Laboratory, Department of Chemistry, Faculty of Science, University of Maragheh, Maragheh, Iran

    GholamReza Mahdavinia

  9. Department of Chemical Engineering, University of South Carolina, Columbia, SC, USA

    Esmaiel Jabbari

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  1. Azar Ramezanpour
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  2. Legha Ansari
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Correspondence to Ali Akbari or Esmaiel Jabbari.

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Ramezanpour, A., Ansari, L., Rahimkhoei, V. et al. Recent advances in carbohydrate-based paclitaxel delivery systems. Polym. Bull. 81, 1043–1069 (2024). https://doi.org/10.1007/s00289-023-04759-9

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  • DOI: https://doi.org/10.1007/s00289-023-04759-9

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