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Biological Synthesis of Silver Nanoparticles from Lavandula mairei Humbert: Antibacterial and Antioxidant Activities

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Abstract

Hospital-acquired infections involving carbapenem-resistant Acinetobacter baumannii (A. baumannii) and extended spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae pose significant challenges in the intensive care units. The lack of novel antimicrobial drugs amplifies the urgency to explore innovative management strategies. Nanotechnology, with its ability to generate nanoparticles possessing specific properties beneficial in drug delivery and nanomedicine, stands as a pivotal research domain. The objective of this study was to synthesize, for the first time, biologically silver nanoparticles (Ag-NPs) from Lavandula mairei Humbert (L. mairei) plant. The biosynthesized Ag-NPs were characterized by UV–visible spectral analysis, X-Ray diffraction Analysis, Fourier transform infrared spectroscopy analysis, scanning electron microscopy (SEM), and energy-dispersive X-ray spectroscopy. Subsequently, the antibacterial and antioxidant activities of Ag-NPs were assessed using the micro-dilution method, DPPH test and FRAP assay, respectively. The green-synthesized Ag-NPs exhibited high antibacterial activity against ESBL-producing multidrug-resistant (MDR) strains and against carbapenem-resistant and non-carbapenem-resistant strains of A. baumannii, as well as a very interesting antioxidant activity. The present study suggests that these results hold very promising for the potential application of biologically synthesized Ag-NPs from L. mairei (Ag-LM-NPs) in the invention of novel antibacterial and antioxidant agents.

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Funding

This work was supported by the Moroccan National center of scientific and technical research (VPMA3; n°: 576/2021), the National Agency for Medicinal and Aromatic Plants, and the Ministry of National Education, Vocational Training, Higher Education, and Scientific Research.

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Authors and Affiliations

  1. Laboratory of Microbial Biotechnology and Plants Protection. Biology, Department. Sciences Faculty, Ibn Zohr University, Agadir, Morocco

    Soufiane EL Megdar, Raja Elkheloui, Asma Laktib, Mohamed Bourouache, Abdellah EL Boulani, Mohamed Hassi, Rachida Mimouni & Fatima Hamadi

  2. Laboratory of Biotechnologies and Valorization of Natural Resources, Biology Department. Sciences Faculty, Ibn Zohr University, Agadir, Morocco

    Lahbib Fayzi, Khalil Cherifi & Fouad Msanda

  3. Green Energy Park, Institut de Recherche en Energie Solaire Et Energies Nouvelles (IRESEN), Benguerir, Morocco

    Hicham Abou Oualid

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  1. Soufiane EL Megdar
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  2. Lahbib Fayzi
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Contributions

Soufiane El megdar contributed to writing of the original draft, writing, reviewing, & editing of the manuscript, methodology, and results analysis; Lahbib Fayzi contributed to methodology and plant extraction; Raja Elkheloui contributed to methodology and writing, reviewing, & editing of the manuscript; Asma Laktib contributed to isolation and identification of bacterial strains; Mohamed Bourouache contributed to statistical analysis; Abdellah El boulani contributed to results analysis; Hicham Abou oualid contributed to visualization and correction; Khalil Cherifi contributed to review and correction of paper; Fouad Msanda contributed to collection and identification of plant; Hassi Mohamed contributed to review and correction of paper; Rachida Mimouni contributed to writing, reviewing, & editing of the manuscript, methodology, and results analysis. Fatima Hamadi contributed to writing of the original draft, writing, reviewing, & editing of the manuscript, methodology, and results analysis.

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Correspondence to Fatima Hamadi.

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EL Megdar, S., Fayzi, L., Elkheloui, R. et al. Biological Synthesis of Silver Nanoparticles from Lavandula mairei Humbert: Antibacterial and Antioxidant Activities. Curr Microbiol 81, 151 (2024). https://doi.org/10.1007/s00284-024-03670-4

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