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Immunotherapy with pluripotent stem cell-derived dendritic cells

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Abstract

In vivo transfer of dendritic cells (DC) has proven efficient in the priming of T cells and is regarded as a powerful means of providing anti-cancer immunotherapy. Clinical trials of anti-cancer therapy with DC pulsed with peptide antigens have been carried out in many institutions, although dramatic therapeutic effect has not been observed in most of the trials. Negative regulation of the immune response by DC might be applicable to treatment of autoimmune diseases and transplantation medicine. Currently, the DC used for anti-cancer vaccine therapy are generated from the peripheral blood monocytes of the patients. However, there is a limitation in the number of available monocytes and the potential of monocytes to differentiate into DC varies depending on the individual blood donors. To resolve the issue of the cell source for DC therapy, several groups have developed methods to generate DC from pluripotent stem cells. This review introduces methods to generate functional DC from pluripotent stem cells of mouse and human.

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Acknowledgments

This work was supported in part by Grants-in-Aid from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan, Research Grant for Intractable Diseases from the Ministry of Health and Welfare, Japan, and grants from Japan Science and Technology Agency (JST).

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Authors and Affiliations

  1. Department of Immunogenetics, Graduate School of Medical Sciences, Kumamoto University, 1-1-1 Honjo, Kumamoto, 860-8556, Japan

    Satoru Senju, Yusuke Matsunaga, Satoshi Fukushima, Shinya Hirata, Yutaka Motomura, Daiki Fukuma, Hidetake Matsuyoshi & Yasuharu Nishimura

  2. CREST, Japan Science and Technology Agency, Tokyo, Japan

    Satoru Senju

Authors
  1. Satoru Senju
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  2. Yusuke Matsunaga
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  3. Satoshi Fukushima
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  4. Shinya Hirata
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  5. Yutaka Motomura
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  6. Daiki Fukuma
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  7. Hidetake Matsuyoshi
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  8. Yasuharu Nishimura
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Correspondence to Satoru Senju.

Additional information

This article is published as part of the Special Issue on Immunopathology of Pluripotent Stem Cell Transplantation [33:6]

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Senju, S., Matsunaga, Y., Fukushima, S. et al. Immunotherapy with pluripotent stem cell-derived dendritic cells. Semin Immunopathol 33, 603–612 (2011). https://doi.org/10.1007/s00281-011-0263-y

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  • DOI: https://doi.org/10.1007/s00281-011-0263-y

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