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Reconstitution of the immune system after hematopoietic stem cell transplantation in humans

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Abstract

Hematopoietic stem cell transplantation is associated with a severe immune deficiency. As a result, the patient is at high risk of infections. Innate immunity, including epithelial barriers, monocytes, granulocytes, and NK cells recovers within weeks after transplantation. By contrast, adaptive immunity recovers much slower. B- and T-cell counts normalize during the first months after transplantation, but in particular, T-cell immunity may remain impaired for years. During the last decade, much of the underlying mechanisms have been identified. These insights may provide new therapies to accelerate recovery.

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Acknowledgment

Eddy Roosnek’s group is supported by a grant from the Swiss National Science Foundation and by the ‘Dr Henri Dubois-Ferrière-Dinu Lipatti’ Foundation.

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Authors and Affiliations

  1. Division of Hematology and Hematologic Malignancies, Department of Medicine, University of Calgary, Calgary, AB, Canada

    Jan Storek, Michelle Geddes & Faisal Khan

  2. Division of Hematology, Department of Internal Medicine, Geneva University Hospitals and University of Geneva, Geneva, Switzerland

    Bertrand Huard, Claudine Helg, Yves Chalandon, Jakob Passweg & Eddy Roosnek

  3. Division of Hematology, HUG, 24 rue Micheli-du-Crest, CH-1211, Geneva 14, Switzerland

    Eddy Roosnek

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  1. Jan Storek
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  8. Eddy Roosnek
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Correspondence to Eddy Roosnek.

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Storek, J., Geddes, M., Khan, F. et al. Reconstitution of the immune system after hematopoietic stem cell transplantation in humans. Semin Immunopathol 30, 425–437 (2008). https://doi.org/10.1007/s00281-008-0132-5

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  • DOI: https://doi.org/10.1007/s00281-008-0132-5

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