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Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9

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Abstract

Plasmacytoid dendritic cell (pDC) precursors, also called type I IFN (α/β/ω)-producing cells (IPCs), are the key effectors in the innate immune system because of their extraordinary capacity to produce type I IFNs against microbial infection, particularly viral infection. In contrast to myeloid DCs, human pDC/IPCs selectively express Toll-like receptor (TLR) 7 and TLR9 within the endosomal compartment. These receptors are specifically designed to recognize the nucleoside-based products derived from RNA viruses and DNA viruses. Therefore, this expression profile potentially enables pDC/IPCs to sense a variety of viruses. Stimulation of TLR7 or TLR9 leads to type I IFN responses through the MyD88 pathway. Thus, pDC/IPCs may play a central role in host defense against viral infection through the TLR7 and TLR9 system.

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Authors and Affiliations

  1. Department of Immunology and CCIR, The University of Texas, M. D. Anderson Cancer Center, Houston, TX, 77030, USA

    Tomoki Ito, Yui-Hsi Wang & Yong-Jun Liu

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  1. Tomoki Ito
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  2. Yui-Hsi Wang
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  3. Yong-Jun Liu
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Correspondence to Tomoki Ito.

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Ito, T., Wang, YH. & Liu, YJ. Plasmacytoid dendritic cell precursors/type I interferon-producing cells sense viral infection by Toll-like receptor (TLR) 7 and TLR9. Springer Semin Immun 26, 221–229 (2005). https://doi.org/10.1007/s00281-004-0180-4

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