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Dendritic cell-mediated T cell polarization

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Abstract

Effective defense against diverse types of micro-organisms that invade our body requires specialized classes of antigen-specific immune responses initiated and maintained by distinct subsets of effector CD4+ T helper (Th) cells. Excessive or detrimental (e.g., autoimmune) responses by effector T cells are controlled by regulatory T cells. The optimal balance in the development of the different types of effector and regulatory Th cells is orchestrated by dendritic cells (DC). This review discusses the way DC adapt the T cell response to the type of pathogen, focusing on the tools that DC use in this management of the T cell response.

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Author notes

  1. Hermelijn H. Smits

    Present address: Department of Parasitology, Leiden University Medical Center, Albinusdreef 2, 2333 ZA, Leiden, The Netherlands

Authors and Affiliations

  1. Department of Cell Biology and Histology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands

    Esther C. de Jong, Hermelijn H. Smits & Martien L. Kapsenberg

  2. Department of Dermatology, Academic Medical Center, University of Amsterdam, Meibergdreef 15, 1100 AZ, Amsterdam, The Netherlands

    Martien L. Kapsenberg

Authors
  1. Esther C. de Jong
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  2. Hermelijn H. Smits
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  3. Martien L. Kapsenberg
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Corresponding author

Correspondence to Esther C. de Jong.

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de Jong, E.C., Smits, H.H. & Kapsenberg, M.L. Dendritic cell-mediated T cell polarization. Springer Semin Immun 26, 289–307 (2005). https://doi.org/10.1007/s00281-004-0167-1

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  • DOI: https://doi.org/10.1007/s00281-004-0167-1

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