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Positron emission tomography to detect bone marrow involvement for patients with follicular lymphoma: a systematic review and meta-analysis

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Abstract

Detection of bone marrow involvement (BMI) for patients with follicular lymphoma (FL) is of great significance for staging and treatment. The clinical value of positron emission tomography/computed tomography (PET/CT) in assessing BMI is still under debate and investigation. PubMed, Embase, Web of Science, and Cochrane Library databases were systematically searched to identify studies evaluating PET/CT in detecting BMI in FL patients. Data extraction and quality evaluation were independently conducted by two reviewers, and nine eligible studies were selected as final quantitative analysis. Nine studies comprising 1119 FL patients were included. The pooled sensitivity was 0.67 (95% CI, 0.38–0.87), and the pooled specificity was 0.82 (95% CI, 0.75–0.87). The pooled positive likelihood ratio, negative likelihood ratio, and diagnostic odds ratio were 3.7 (95% CI, 2.1–6.3), 0.4 (95% CI, 0.18–0.91), and 9 (95% CI, 2–33), respectively. The area under the curve of PET/CT to detect BMI in FL patients was 0.83 (95% CI, 0.8–0.86). Current evidence suggests that PET/CT cannot replace bone marrow biopsy to detect BMI, but it is still of partial clinical significance for the prognosis of patients with follicular lymphoma.

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Data availability

The datasets used and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Funding

C. T. is supported by the Natural Science Foundation of Xinjiang Autonomous Region (2022D01A09), Grant ZC20171, from Tianjin Health Science and Technology Project and Tianjin Key Medical Discipline (Specialty) Construction Project (TJYXZDXK-009A).

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Author notes

  1. Yaxin Zheng, Jun Liu, and Junqi Si are co-first authors.

Authors and Affiliations

  1. Tianjin Medical University Cancer Institute and Hospital, National Clinical Research Center for Cancer, Key Laboratory of Cancer Prevention and Therapy, Tianjin’s Clinical Research Center for Cancer, Tianjin, 300060, China

    Yaxin Zheng, Junqi Si, Qiang Xue & Chen Tian

  2. Sunshine Union Hospital, Weifang, Shandong, China

    Jun Liu

  3. Department of Hematology, Hotan District People’s Hospital, 848000, Hotan, Xinjiang, China

    Qiang Xue, Dan Chen, Rexidan Nuermaimaiti & Chen Tian

Authors
  1. Yaxin Zheng
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  2. Jun Liu
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  4. Qiang Xue
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  5. Dan Chen
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Contributions

Y. Z., X. L., and H. L. acquired and analyzed the data, and wrote the paper. J. L., J. S., Q. X., D. C., and R. N. revised the manuscript. C. T. and Y. W. proposed the research idea and critically revised the manuscript. All authors approved all versions including the final version, and were responsible for the accuracy and integrity of all aspects of the manuscript.

Corresponding author

Correspondence to Chen Tian.

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This study was subject to approval by the Research Ethics Committee of Tianjin Medical University Cancer Institute and Hospital.

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The authors declare no competing interests.

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Novelty statements

PET/CT cannot replace bone marrow biopsy to diagnose bone marrow infiltration, but it is still of partial clinical significance for the prognosis of patients with follicular lymphoma.

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Zheng, Y., Liu, J., Si, J. et al. Positron emission tomography to detect bone marrow involvement for patients with follicular lymphoma: a systematic review and meta-analysis. Ann Hematol 102, 2403–2412 (2023). https://doi.org/10.1007/s00277-023-05274-7

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  • DOI: https://doi.org/10.1007/s00277-023-05274-7

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