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Real-world experience and considerations on concomitant caplacizumab and anticoagulation in thrombotic thrombocytopenic purpura

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References

  1. Hollifield AL, Arnall JR, Moore DC (2020) Caplacizumab: an anti-von Willebrand factor antibody for the treatment of thrombotic thrombocytopenic purpura. Am J Health Syst Pharm 77(15):1201–1207

    Article  Google Scholar 

  2. Zheng XL, Vesely SK, Cataland SR et al (2020) ISTH guidelines for the diagnosis of thrombotic thrombocytopenic purpura. J Thromb Haemost 18:2486–2495. https://doi.org/10.1111/jth.15006

    Article  Google Scholar 

  3. Elverdi T et al (2021) Do patients with immune-mediated thrombotic thrombocytopenic purpura receiving caplacizumab need antithrombotic therapy? Expert Rev Clin Pharmacol 14:1183–1188

    Article  CAS  Google Scholar 

  4. Peyvandi F et al (2016) Caplacizumab for acquired thrombotic thrombocytopenic purpura. N Engl J Med 374:511–522. https://doi.org/10.1056/JENMoa1505533

    Article  CAS  Google Scholar 

  5. Scully M et al (2019) Caplacizumab treatment for acquired thrombotic thrombocytopenic purpura. N Engl J Med 380:335–346. https://doi.org/10.1056/NEJMoa1806311

    Article  CAS  Google Scholar 

  6. Peyvandi F et al (2017) Caplacizumab reduces the frequency of major thromboembolic events, exacerbations, and death in patients with acquired thrombotic thrombocytopenic purpura. J Thromb Haemost 15:1448–1452. https://doi.org/10.1111/jth.13716

    Article  CAS  Google Scholar 

  7. Dutt T et al (2021) Real-world experience with caplacizumab in the management of acute TTP. Blood 137:1731–1740. https://doi.org/10.1182/blood.2020007599

    Article  CAS  Google Scholar 

  8. Tse B et al (2020) Describing the point prevalence and characteristics of venous thromboembolism in patients with thrombotic thrombocytopenic purpura. J Thromb Haemost 18:2870–2877. https://doi.org/10.1111/jth.15027

    Article  CAS  Google Scholar 

  9. Picod A, Veyradier A, Coppo P (2021) Should all patients with immune-mediated thrombotic thrombocytopenic purpura receive caplacizumab? J Thromb Haemost 19:58–67. https://doi.org/10.1111/jth.15194

    Article  Google Scholar 

  10. Benhamou Y et al (2020) Venous thrombo-embolism during immune-mediated thrombotic thrombocytopenic purpura is prevalent in patients with a prolonged treatment with therapeutic plasma exchange. La Revue de Medicine Intern 41:809–813. https://doi.org/10.1016/j.revmed.2020.06.014

    Article  CAS  Google Scholar 

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Correspondence to Justin Arnall.

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Research involving human participants and/or animals

N/A. This is a case report of therapy selection and response to therapy outside of a clinical trial. This article does not contain any studies with human participants performed by any of the authors.

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N/A. Institutional review board reviewed, and patient consent identified as not required.

Conflict of interest

Donald Moore has served on advisor boards for Pfizer, AstraZeneca, and Janssen. Justin Arnall is supported by Novo Nordisk (Hemophilia) Speaker’s Bureau, CTI Biopharma Advisory Board. The rest of the authors declare no competing interests.

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Meek, B., Desai, N., Moore, D.C. et al. Real-world experience and considerations on concomitant caplacizumab and anticoagulation in thrombotic thrombocytopenic purpura. Ann Hematol 102, 457–459 (2023). https://doi.org/10.1007/s00277-022-05049-6

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  • DOI: https://doi.org/10.1007/s00277-022-05049-6

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