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Cell surface expression of CD25 antigen (surface IL-2 receptor alpha-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients

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Abstract

Using the database of the Israeli CLL Study Group, we investigated the incidence and prognostic significance of CD25 expression on the surface of lymphocytic leukemia cells. Strong CD25 expression was found in 46 (16.4 %) of 281 tested cases and was correlated with the presence of splenomegaly (p = 0.04), expression of CD38 antigen (p = 0.001), and FMC-7 (p = 0.04). Age, gender, Binet stage, circulating lymphocyte count, presence of anemia or thrombocytopenia, atypical cell morphology, serum beta 2-microglobulin level, and ZAP-70 expression did not differ in patients with or without cell surface CD25. There was no correlation between CD25 expression and time to first treatment or overall survival. CD25 expression does not appear to be a prognostic factor in CLL.

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Authors and Affiliations

  1. Kaplan Medical Center, Rehovot, affiliated with Hadassah and Hebrew University Medical School, Jerusalem, Israel

    Lev Shvidel, Mordechai Shtalrid & Alain Berrebi

  2. Western Galilee Hospital, Nahariya, affiliated with Bar Ilan University, Ramat Gan, Israel

    Andrei Braester

  3. Rabin Medical Center, Petah-Tikva, affiliated with Tel Aviv Medical University, Petah-Tikva, Israel

    Osnat Bairey

  4. Assaf Harofeh Medical Center, Zerifin, affiliated with Tel Aviv Medical University, Tzrifin, Israel

    Naomi Rahimi-Levene

  5. Sourasky Medical Center, Tel-Aviv, affiliated with Tel Aviv Medical University, Tel Aviv, Israel

    Yair Herishanu

  6. Bnai Zion Medical Center, Haifa, affiliated with Technion, Haifa, Israel

    Tamar Tadmor

  7. Wolfson Medical Center, Holon, affiliated with Tel Aviv Medical University, Holon, Israel

    Abraham Klepfish

  8. Shaare Zedek Medical Center, Jerusalem, affiliated with Ben Gurion University, Beer Sheva, Israel

    Rosa Ruchlemer

  9. Hadassah University Hospital and Hebrew University Medical School, Jerusalem, Israel

    Aaron Polliack

  10. Hematology Institute, Kaplan Medical Center, Rehovot, Israel, 76100

    Lev Shvidel

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  1. Lev Shvidel
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  2. Andrei Braester
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  10. Alain Berrebi
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  11. Aaron Polliack
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on behalf of the Israeli CLL Study Group

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Correspondence to Lev Shvidel.

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Shvidel, L., Braester, A., Bairey, O. et al. Cell surface expression of CD25 antigen (surface IL-2 receptor alpha-chain) is not a prognostic marker in chronic lymphocytic leukemia: results of a retrospective study of 281 patients. Ann Hematol 91, 1597–1602 (2012). https://doi.org/10.1007/s00277-012-1492-4

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  • DOI: https://doi.org/10.1007/s00277-012-1492-4

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