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Comparative analysis of outcomes of allogeneic peripheral blood stem cell transplantation from related and unrelated donors

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Abstract

This study compared the results of allogeneic peripheral blood stem cell transplantation (PBSCT) from unrelated and related donors, and involved 235 consecutive patients from ten centers between Jan 2004 and Dec 2008. Among these patients, 160 (68.1%) received a human leukocyte antigen-matched related PBSCT and 75 (31.9%), a matched unrelated PBSCT. The cumulative incidence of acute graft-versus-host disease (GVHD) was 43.9% for the related PBSCT and 59.3% for the unrelated PBSCT. Although the cumulative incidence of chronic GVHD was no different between the related (54.2%) and unrelated (64.9%) PBSCT, the cumulative incidence of extensive chronic GVHD was higher among the unrelated PBSCT (34.9%) than among the related PBSCT (17.0%). The overall survival rate at 4 years was 58.2% versus 49.1%, and the cumulative incidence of relapse was 28.4% versus 25.0% for the related and unrelated PBSCT, respectively. Among the factors examined, unrelated PBSCT, the CD34-positive cell count, and cytomegalovirus infection were all related with a higher incidence of extensive chronic GVHD. However, in a multivariate analysis, only unrelated PBSCT was identified as a risk factor for the development of extensive chronic GVHD (hazard ratio = 2.012; P value, 0.048). In conclusion, the survival and relapse incidence were not significantly different between the related and unrelated PBSCT.

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Acknowledgements

This study was supported by the Korean Society of Hematopoietic Stem Cell Transplantation. The authors would also like to thank the staff at each center.

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Authors and Affiliations

  1. Department of Hematology/Oncology, Kyungpook National University Hospital, Kyungpook National University School of Medicine, 200 Dongduk-Ro, Jung-Gu, Daegu, 700-712, South Korea

    Byung Woog Kang, Joon Ho Moon, Yee Soo Chae, Jong Gwang Kim & Sang Kyun Sohn

  2. Department of Hematology/Oncology, Pusan National University Hospital, Pusan National University School of Medicine, Busan, South Korea

    Joo Seop Jung & Goon-Jae Cho

  3. Department of Internal Medicine, Chungnam National University College of Medicine, Chungnam National University Hospital, Daejeon, South Korea

    Deog-Yeon Jo

  4. Department of Hematology/Oncology, Chonnam National University Hwasun Hospital, Hwasun, South Korea

    Yeo Kyeoung Kim & Hyeoung Joon Kim

  5. Division of Hematology-Oncology, Department of Internal Medicine, Daegu Catholic University College of Medicine, Daegu, South Korea

    Hun-Mo Ryoo

  6. Hematology-Oncology Clinic, National Cancer Center of Korea, Goyang, South Korea

    Hyeon Seok Eom

  7. Department of Oncology/Hematology, Busan Paik Hospital, Inje University College of Medicine, Busan, South Korea

    Sang Min Lee & Young-Don Joo

  8. Department of Internal Medicine, Soon Chun Hyang University College of Medicine, Seoul, South Korea

    Jong-Ho Won

  9. Department of Internal Medicine, Wonkwang University School of Medicine, Iksan, South Korea

    Moo Rim Park

  10. Department of Internal Medicine, Yeungnam University College of Medicine, Daegu, South Korea

    Min Kyung Kim & Myung Soo Hyun

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  1. Byung Woog Kang
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  2. Joon Ho Moon
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  3. Yee Soo Chae
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  8. Yeo Kyeoung Kim
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  9. Hyeoung Joon Kim
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  11. Hyeon Seok Eom
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  12. Sang Min Lee
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  13. Young-Don Joo
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  14. Jong-Ho Won
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  15. Moo Rim Park
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  16. Min Kyung Kim
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  17. Myung Soo Hyun
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  18. Sang Kyun Sohn
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Correspondence to Sang Kyun Sohn.

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Kang, B.W., Moon, J.H., Chae, Y.S. et al. Comparative analysis of outcomes of allogeneic peripheral blood stem cell transplantation from related and unrelated donors. Ann Hematol 89, 813–820 (2010). https://doi.org/10.1007/s00277-010-0913-5

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  • DOI: https://doi.org/10.1007/s00277-010-0913-5

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