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Long-term propylthiouracil use and acute myeloid leukemia: A case report and review of the literature

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References

  1. Aycan Z, Arhan E, Çetinkaya E, Vidinlisan S, Menekse N, Yücel H, Cakar N (2006) Propylthiouracil-induced hypersensitivity syndrome. Turk J Pediatr 48:162–165

    PubMed  Google Scholar 

  2. Gungor KGS, Kisakol GDO, Kaya A (2006) ANCA positive propylthiouracil induced pyoderma gangrenosum. J Endocrinol Invest 29:575–576

    PubMed  CAS  Google Scholar 

  3. Sheen Y, Chu C, Yu H (2006) Antineutrophil cytoplasmic antibody-positive cutaneous leukocytoclastic vasculitis associated with propylthiouracil therapy. Arch Dermatol 142:879–880

    Article  PubMed  Google Scholar 

  4. Cetina J, Fishbein E-SD (1972) Antinuclear antibodies and propylthiouracil therapy. JAMA 220:1012

    Article  PubMed  CAS  Google Scholar 

  5. Bistrom O (1950) The effect of methyl- and propylthiouracil on the histology of the thyroid and pituitary and on the bone marrow in rats. Ann Med Exp Biol Fenn 28:1–21

    Article  PubMed  CAS  Google Scholar 

  6. Futcher P, Massie E (1950) Agranulocytosis due to propylthiouracil. Ann Intern Med 32:137

    PubMed  CAS  Google Scholar 

  7. De La Balze F, Celani Barry R, Arrillaga F, Mancini R (1952) Effect of methylthiouracil and propylthiouracil on the number of circulatory eosinophils and eosinopoiesis in the bone marrow in hyperthyroidism and in normal subjects. Medicina (B Aires) 12:1–16

    Google Scholar 

  8. Lipsky J, Gallego M (1988) Mechanism of thionamide antithyroid drug associated hypoprothrombinemia. Drug Metabol Drug Interact 6:317–326

    PubMed  CAS  Google Scholar 

  9. Akarsu E, Buyukhatipoglu H, Aktaran SGR (2006) Propylthiouracil-related hemorrhagic diathesis: a case report and review of the literature. Mt Sinai J Med 73

  10. Sammon T, Peden V, Witzleben C, King J (1971) Disseminated intravascular coagulation complicating propylthiouracil therapy. A case description of a 16-year-old girl. Clin Pediatr (Phila) 10:739–742

    Article  CAS  Google Scholar 

  11. Fewell R, Engel E, Zimmerman S (1950) Acute thrombopenic purpura associated with administration of propylthiouracil. J Am Med Assoc 143:891–892

    PubMed  CAS  Google Scholar 

  12. Martelo O, Katims R, Yunis A (1967) Bone marrow aplasia following propylthiouracil therapy. Report of a case with complete recovery. Arch Intern Med 120:587–590

    Article  PubMed  CAS  Google Scholar 

  13. Aksoy M, Erdem S (1968) Aplastic anaemia after propylthiouracil. Lancet 1:1379

    Article  PubMed  CAS  Google Scholar 

  14. Aksoy M, Erdem S, Tezel H, Tezel T (1974) Letter: acute myeloblastic leukaemia after propylthiouracil. Lancet 1:928–929

    Article  PubMed  CAS  Google Scholar 

  15. Azizerli H, Aksoy M, Alagol F (1988) Acute myeloblastic leukemia after propyl-thio-uracil, a simple coincidence? Acta Haematol 79:229

    Article  PubMed  CAS  Google Scholar 

  16. Larson R (2007) Is secondary leukemia an independent poor prognostic factor in acute myeloid leukemia? Best Pract Res Clin Haematol 20:29–37

    Article  PubMed  Google Scholar 

  17. Richkind K, Hromas R, Lytle C, Crenshaw D, Velasco J, Roherty S, Srinivasiah J, Varella-Garcia M (2000) Identification of two new translocations that disrupt the AML1 gene. Cancer Genet Cytogenet 122:141–143

    Article  PubMed  CAS  Google Scholar 

  18. Izumi T, Ohtsuki T, Ohya KOY, Yoshida M, Muroi K, Imagawa SHK, Kuriki K, Saito K, Miura Y (1996) Therapy-related leukemia with a novel 21q22 rearrangement. Cancer Genet Cytogenet 90:45–48

    Article  PubMed  CAS  Google Scholar 

  19. Schlaifer D, Cooper M, Attal M, Rousseau A, Pris J, Laurent G, Myers C (1994) Potential strategies for circumventing myeloperoxidase-catalyzed degradation of vinca alkaloids. Leukemia 8:668–671

    PubMed  CAS  Google Scholar 

  20. Lee E, Kariya K (1986) Propylthiouracil, a selective inhibitor of NADH-cytochrome b5 reductase. FEBS Lett 209:49–51

    Article  PubMed  CAS  Google Scholar 

  21. Kurian JR, Bajad SU, Miller JL, Chin NA, Trepanier LA (2004) NADH cytochrome b5 reductase and cytochrome b5 catalyze the microsomal reduction of xenobiotic hydroxylamines and amidoximes in humans. J Pharmacol Exp Ther 311:1171–1178

    Article  PubMed  CAS  Google Scholar 

  22. Saulter JY, Kurian JR, Trepanier LA, Tidwell RR, Bridges AS, Boykin DW, Stephens CE, Anbazhagan M, Hall JE (2005) Unusual dehydroxylation of antimicrobial amidoxime prodrugs by cytochrome b5 and NADH cytochrome b5 reductase. Drug Metab Dispos 33:1886–1893

    PubMed  CAS  Google Scholar 

  23. Tsan MPA (1975) Stimulation by propylthiouracil of the hexose monophosphate shunt in human polymorphonuclear leucocytes during phagocytosis. Br J Haematol 31:193–208

    PubMed  CAS  Google Scholar 

  24. Wing S, Fantus I (1987) Adverse immunologic effects of antithyroid drugs. CMAJ 136:121–127

    PubMed  CAS  Google Scholar 

  25. Hallengren B, Melander A, Thesleff S (1984) Local anaesthesia and immunomodulatory effects of antithyroid drugs. Acta Endocrinol (Copenh) 106:336–337

    CAS  Google Scholar 

  26. Hallengren B, Forsgren A, Melander A (1980) Effects of antithyroid drugs on lymphocyte function in vitro. J Clin Endocrinol Metab 51:298–301

    Article  PubMed  CAS  Google Scholar 

  27. Kariya K, Lee E, Hirouchi M (1984) Relationship between leukopenia and bone marrow myeloperoxidase in the rat treated with propylthiouracil. Jpn J Pharmacol 36:217–222

    PubMed  CAS  Google Scholar 

  28. Iitaka M, Iwatani Y, Gerstein H, Row V, Volpe R (1987) Immunomodulatory effect of the treatment of Graves’ disease on antigen-specific monocyte procoagulant activity production. Clin Endocrinol (Oxf) 27:321–330

    CAS  Google Scholar 

  29. Wilson R, McKillop J, Chopra M, Thomson J (1988) The effect of antithyroid drugs on B and T cell activity in vitro. Clin Endocrinol (Oxf) 28:389–397

    CAS  Google Scholar 

  30. Ferguson M, McDonald F, Alexander W (1985) Inhibition of NK cell-induced cytolysis by thiocarbamide antithyroid drugs. Immunol Lett 11:117–120

    Article  PubMed  CAS  Google Scholar 

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Authors and Affiliations

  1. Division of Hematology, Azienda Ospedaliera Universitaria Santa Chiara, Pisa, Italy

    Daniele Focosi, Francesco Caracciolo, Sara Galimberti, Federico Papineschi & Mario Petrini

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  1. Daniele Focosi
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  2. Francesco Caracciolo
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  3. Sara Galimberti
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  4. Federico Papineschi
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  5. Mario Petrini
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Correspondence to Daniele Focosi.

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Focosi, D., Caracciolo, F., Galimberti, S. et al. Long-term propylthiouracil use and acute myeloid leukemia: A case report and review of the literature. Ann Hematol 87, 233–235 (2008). https://doi.org/10.1007/s00277-007-0369-4

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  • DOI: https://doi.org/10.1007/s00277-007-0369-4

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