Abstract
Chlamydia pneumoniae is known to cause acute respiratory tract infections in the non-immunocompromised population. So far, no data about the incidence of chlamydial infections in neutropenic patients are available. Macrolide antibiotics are not considered to be first-line treatment options in neutropenic patients. We report the case of a patient with Hodgkin’s disease who developed C. pneumoniae pneumonia during mild neutropenia. C. pneumoniae should be considered as a causative agent of pneumonia in neutropenic patients.
Similar content being viewed by others
References
Balis E, Boufas A, Iliopoulos I, Legakis NJ, Zerva L (2003) Severe community-acquired pneumonia with acute hypoxemic respiratory failure due to primary infection with Chlamydia pneumoniae in a previously healthy adult. Clin Infect Dis 36:e155–e157
Dowell SF, Peeling RW, Boman J, Carlone GM, Fields BS, Guarner J, Hammerschlag MR, Jackson LA, Kuo CC, Maass M, Messmer TO, Talkington DF, Tondella ML, Zaki SR (2001) Standardizing Chlamydia pneumoniae assays: recommendations from the Centers for Disease Control and Prevention (USA) and the Laboratory Centre for Disease Control (Canada). Clin Infect Dis 33:492–503
File TM Jr, Plouffe JF Jr, Breiman RF, Skelton SK (1999) Clinical characteristics of Chlamydia pneumoniae infection as the sole cause of community-acquired pneumonia. Clin Infect Dis 29:426–428
Heinemann M, Kern WV, Bunjes D, Marre R, Essig A (2000) Severe Chlamydia pneumoniae infection in patients with neutropenia: case reports and literature review. Clin Infect Dis 31:181–184
Hughes WT, Armstrong D, Bodey GP, Bow EJ, Brown AE, Calandra T, Feld R, Pizzo PA, Rolston KV, Shenep JL, Young LS (2002) 2002 guidelines for the use of antimicrobial agents in neutropenic patients with cancer. Clin Infect Dis 34:730–751
Kauppinen M, Saikku P (1995) Pneumonia due to Chlamydia pneumoniae: prevalence, clinical features, diagnosis, and treatment. Clin Infect Dis 21 [Suppl 3]:S244–S252
Kuo CC, Jackson LA, Campbell LA, Grayston JT (1995) Chlamydia pneumoniae (TWAR). Clin Microbiol Rev 8:451–461
Link H, Blumenstengel K, Bohme A, Cornely O, Kellner O, Nowrousian MR, Ostermann H, Schiel X, Wilhelm M (1999) Antimicrobial therapy for fever of unknown origin in neutropenia. Standard recommendations of the Working Group of Infections in Hematology and Oncology of the German Association of Hematology and Oncology (in German). Dtsch Med Wochenschr 124 [Suppl 1]:S3–S8
Zver S, Kozelj M, Cernelc P (1997) Chlamydia pneumoniae pneumonia with acute hemorrhagic pericarditis in patient with acute leukemia. Haematologica 82:254
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Hummel, M., Hofheinz, R. & Buchheidt, D. Severe Chlamydia pneumoniae infection in a patient with mild neutropenia during treatment of Hodgkin’s disease. Ann Hematol 83, 441–443 (2004). https://doi.org/10.1007/s00277-003-0799-6
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00277-003-0799-6