Abstract
The median nerve maintains a close relationship with the brachial artery in the upper limb. Variability in the formation and distribution of upper extremity vessels is frequently encountered during donor body dissections or surgical procedures. This case presents a rare anatomical variation of the brachial artery emerging through an opening in the median nerve. The median nerve formed a small opening without the contribution from additional nerve roots and the remaining vasculature of the upper limb was otherwise normal. An abnormal arrangement of a neurovascular bundle in the arm can cause sensory and motor issues, as well as vascular implications. This variation has clinical significance in surgical interventions and potentially daily functioning. To our knowledge, this is the first report of a small median nerve opening pierced by the brachial artery.
Similar content being viewed by others
Availability of data and materials
There is no dataset associated with this case report.
References
Al-Qattan MM, Yang Y, Kozin SH (2009) Embryology of the upper limb. J Hand Surg Am 34(7):1340–1350. https://doi.org/10.1016/j.jhsa.2009.06.013
Bhat KM, Gowda S, Potu BK (2009) Nerve loop around the axillary vessels by the roots of the median nerve a rare variation in a south Indian male cadaver: a case report. Cases J 2:179. https://doi.org/10.1186/1757-1626-2-179
Chou HC, Jeng H, Ko TL, Pai MH, Chang CY, Wu CH (2001) Variant palmaris profundus enclosed by an unusual loop of the median nerve. J Anat 199(4):499–500. https://doi.org/10.1046/j.1469-7580.2001.19940499.x
Ghosh B, Dilkash MNA, Prasad S, Sinha SK (2022) Anatomical variation of median nerve: cadaveric study in brachial plexus. Anat Cell Biol 55(2):130–134. https://doi.org/10.5115/acb.22.022
Kim DH, Hudson AR, Kline DG (2013) Atlas of peripheral nerve surgery, 2nd edn. Saunders, Philadelphia
Konarik M, Musil V, Baca V, Kachlik D (2020) Upper limb principal arteries variations: a cadaveric study with terminological implication. Bosn J Basic Med Sci 20(4):502–513. https://doi.org/10.17305/bjbms.2020.4643
Mat Taib CN, Hassan SN, Esa N, Mohd Moklas MA, San AA (2017) Anatomical variations of median nerve formation, distribution and possible communication with other nerves in preserved human cadavers. Folia Morphol (Warsz) 76(1):38–43. https://doi.org/10.5603/FM.a2016.0045
Nulle K, Jaudzema A (2021) Ultrasonographic evaluation of the median nerve: normal and variant anatomy and appearance. J Ultrason 21(87):e318–e325. https://doi.org/10.15557/JoU.2021.0053
Paraskevas G, Lazaridis N, Piagkou M, Natsis K (2018) Superficial brachial artery traversing a median nerve loop in the arm associated with other vascular and muscular anomalies: case report and clinical implications. Ital J Anat Embryol 123(1):17–22. https://doi.org/10.13128/IJAE-23006
Paraskevas GK, Varnalidis I, Koutsouflianiotis K (2017) Median nerve’s loop in the arm penetrated by a superficial brachial artery: case report and neurosurgical considerations. Int J Res Med Sci 3(8):2123–2125
Pavlovsky E, Kistner G, Loomis M (2023) A persistent median artery piercing the median nerve: a review and clinical implications. Bull Natl Res Cent. https://doi.org/10.1186/s42269-023-01057-2
Rodríguez-Niedenführ M, Burton GJ, Deu J, Sañudo JR (2001) Development of the arterial pattern in the upper limb of staged human embryos: normal development and anatomic variations. J Anat 199:407–417. https://doi.org/10.1046/j.1469-7580.2001.19940407.x
Roy TS (2003) Median nerve penetration by a muscular branch of the brachial artery. Clin Anat 16(4):335–339. https://doi.org/10.1002/ca.10080
Saenz C, Rahimi OB, Kar R (2022) Cadaveric study of division of the median nerve by the persistent median artery. Surg Radiol Anat 44:1455–1460. https://doi.org/10.1007/s00276-022-03035-1
Standring S, Gray H (2021) Gray’s anatomy: the anatomical basis of clinical practice, 42nd edn. Elsevier, Amsterdam
Sthapak E, Pasricha N, Bhatnagar R (2019) Relation of median nerve with brachial artery: a cadaveric study. J Anat Science 27:10–14
Acknowledgements
The authors thank those who generously donated their bodies to medical science. Anatomical research has the potential to expand our collective knowledge and ultimately improve patient care. Therefore, these donors and their families deserve our upmost gratitude. The authors would also like to thank the medical students that participated in the main dissection of this donor body: William Rutkowski, Allyssa Thomas, Alex Velaoras, Anastasia Kapitonava, Annika Kim, Danny Quraishi, Juliette van Heerden, Kian Robinson, Prachi Gaddam, and Tessa Palisoc.
Funding
N/A.
Author information
Authors and Affiliations
Contributions
Both authors contributed to the study conception and design, material preparation, data collection and analysis. The first draft of the manuscript was written by William E. Rutkowski and both authors contributed to edits on additional versions of the manuscript. Both authors read and approved the final manuscript.
Corresponding author
Ethics declarations
Conflict of interest
The authors did not receive financial support from any organization for the submitted work. The authors declare that they do not have any pertinent conflicts of interest.
Ethical approval
The human donor body used in this study was obtained from the Humanity Gifts Registry, a nonprofit agency of the Commonwealth of Pennsylvania. The donor provided premortem informed consent to anatomy education and research. The Drexel University Institutional Review Board Committee confirmed that no additional ethical approval is required.
Additional information
Publisher's Note
Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.
Rights and permissions
Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.
About this article
Cite this article
Rutkowski, W.E., Howe, C.A. Variation of the brachial artery emerging through an opening in the median nerve: a case report. Surg Radiol Anat 45, 1135–1138 (2023). https://doi.org/10.1007/s00276-023-03227-3
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00276-023-03227-3