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Pathologic Diagnosis and Genetic Analysis of Sequential Biopsy Following Coaxial Low-Power Microwave Thermal Coagulation For Pulmonary Ground-Glass Opacity Nodules

  • Clinical Investigation
  • Non-Vascular Interventions
  • Published:
CardioVascular and Interventional Radiology Aims and scope Submit manuscript

Abstract

Purpose

To evaluate the feasibility, safety, and diagnostic performance of sequential core-needle biopsy (CNB) technique following coaxial low-power microwave thermal coagulation (MTC) for ground-glass opacity (GGO) nodules.

Materials and Methods

From December 2017 to July 2019, a total of 32 GGOs (with diameter of 12 ± 4 mm) in 31 patients received two times of CNBs, both prior to and immediately after MTC at a power of 20 watts. The frequency and type of complications associated with CNBs were examined. The pathologic diagnosis and genetic analysis were performed for specimens obtained from the two types of biopsy.

Results

The technical success rates of pre- and post-MTC CNBs were 94% and 100%, respectively. The complication rate was significantly lower with post-MTC CNB as compared to pre-MTC CNB (42% versus 97%, p < 0.001). Larger amount of specimens could be obtained by post-MTC CNB. The pathological diagnosis rate of post-MTC CNB was significantly higher than that of pre-MTC CNB (100% versus 75%, p = 0.008), whereas the success rates of genetic analysis were comparable between the two groups (100% versus 84%, p = 0.063). Regular ablation could be further performed after post-MTC CNB to achieve local tumor control.

Conclusion

Sequential biopsy following coaxial low-power MTC can reduce the risk of complications and provide high-quality specimens for pulmonary GGOs. Combining this technique with standard ablation allows for simultaneous diagnosis and treatment within a single procedure.

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Acknowledgements

This is a retrospective analysis of prospectively collected data. This study was approved by the institutional review board of our hospital (No. [2017]036) and was compliant with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. Informed consent was obtained from all participants included in this study. Jiachang Chi and Min Ding collected the data of the patients, designed the pipeline of the analysis and drafted the manuscript. Bo Zhai conceived and coordinated the overall study and revised the manuscript. All authors read and approved the final manuscript.

Funding

This study was funded by the Innovation Funding of Renji Hospital (No. PY2018-III-11).

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Author notes

  1. Jiachang Chi and Min Ding authors contributed equally to this study.

Authors and Affiliations

  1. Department of Interventional Oncology, School of Medicine, Renji Hospital, Shanghai Jiaotong University, 160# Pujian Road, Shanghai, 200127, China

    Jiachang Chi, Min Ding, Zhi Wang, Hao Hu, Yaoping Shi, Dan Cui & Bo Zhai

  2. Department of Thoracic Surgery, School of Medicine, Renji Hospital, Shanghai Jiaotong University, Shanghai, China

    Xiaojing Zhao

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  1. Jiachang Chi
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Correspondence to Bo Zhai.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards. For this type of study formal consent is not required.

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Chi, J., Ding, M., Wang, Z. et al. Pathologic Diagnosis and Genetic Analysis of Sequential Biopsy Following Coaxial Low-Power Microwave Thermal Coagulation For Pulmonary Ground-Glass Opacity Nodules. Cardiovasc Intervent Radiol 44, 1204–1213 (2021). https://doi.org/10.1007/s00270-021-02782-9

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  • DOI: https://doi.org/10.1007/s00270-021-02782-9

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