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Contrast-Enhanced Ultrasonography for the Early Evaluation of Prostate Artery Embolization

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Abstract

Aim

To prospectively evaluate the feasibility and reproducibility of the semiquantitative measurement of the unenhanced area of the prostate by trans-abdominal contrast-enhanced ultrasound (CEUS) performed immediately after prostate artery embolization (PAE) as a prognostic factor of success.

Methods

Thirty-nine patients with PAE were prospectively included. They all underwent pre- and post-PAE trans-abdominal prostate CEUS. Two readers independently evaluated the pre- and post-PAE unenhanced area using a semiquantitative method: unenhanced areas were measured on 3 different slices (basis, middle, and apex) and reported to the whole prostate area. The mean of the three measures was reported semiquantitatively in classes of ten percent and quartiles. We evaluated correlation with clinical success, at 3 months after PAE, defined as a > 25% reduction in the International Prostatic Symptoms Score and a Quality of life < 3.

Results

Twenty-three patients who had bilateral PAE were analyzed. Pre-PAE trans-abdominal prostate CEUS showed visible early and marked enhancement of the entire prostate in all patients. After PAE, all patients had a semiquantitatively measured unenhanced area > 25%. The semiquantitative measurement was found to be highly reproducible, with an interclass correlation > 0.8. No correlation was found between the area of unenhanced tissue and clinical success evaluated at 3 months.

Conclusion

Trans-abdominal prostate CEUS performed early after PAE provides reproducible results and is a valuable tool to evaluate unenhanced areas of the prostate.

Level of Evidence

3, local non random sample.

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Funding

This study was not supported by any funding.

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Authors and Affiliations

  1. Department of Body and Interventional Radiology, Hôpital Cochin, AP-HP, Université de Paris-Descartes Paris 5, Paris, 75014, France

    Maxime Barat

  2. Department of Interventional Radiology, Hôpital Européen Georges Pompidou, AP-HP, Université de Paris-Descartes Paris 5, Paris, 75015, France

    Tom Boeken, Nadia Moussa, Alessandro Di Gaeta, Carole Déan, C. Del Giudice, Olivier Pellerin & Marc Sapoval

  3. Department of Urology, Hôpital Européen Georges Pompidou, AP-HP, Université de Paris-Descartes Paris 5, Paris, 75015, France

    Nicolas Thioun

  4. Department of Radiology, Hôpital Cochin, AP-HP, 27 rue du Faubourg Saint-Jacques, Paris, 75014, France

    Maxime Barat

Authors
  1. Maxime Barat
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  2. Tom Boeken
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  3. Nadia Moussa
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  4. Alessandro Di Gaeta
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  5. Carole Déan
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  6. Nicolas Thioun
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  7. C. Del Giudice
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  8. Olivier Pellerin
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  9. Marc Sapoval
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Corresponding author

Correspondence to Maxime Barat.

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Conflict of interest

The authors declare that they have no conflict of interest related with this study.

Ethical Approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Declaration of Helsinki and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Consent for publication was obtained for every individual person’s data included in the study.

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Barat, M., Boeken, T., Moussa, N. et al. Contrast-Enhanced Ultrasonography for the Early Evaluation of Prostate Artery Embolization. Cardiovasc Intervent Radiol 43, 1498–1504 (2020). https://doi.org/10.1007/s00270-020-02518-1

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  • DOI: https://doi.org/10.1007/s00270-020-02518-1

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