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Comparison of Survival Rate in Primary Non-Small-Cell Lung Cancer Among Elderly Patients Treated With Radiofrequency Ablation, Surgery, or Chemotherapy

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Abstract

Purpose

We retrospectively compared the survival rate in patients with non-small-cell lung cancer (NSCLC) treated with radiofrequency ablation (RFA), surgery, or chemotherapy according to lung cancer staging.

Materials and Methods

From 2000 to 2004, 77 NSCLC patients, all of whom had WHO performance status 0–2 and were >60 years old, were enrolled in a cancer registry and retrospectively evaluated. RFA was performed on patients who had medical contraindications to surgery/unsuitability for surgery, such as advanced lung cancer or refusal of surgery. In the RFA group, 40 patients with inoperable NSCLC underwent RFA under computed tomography (CT) guidance. These included 16 patients with stage I to II cancer and 24 patients with stage III to IV cancer who underwent RFA in an adjuvant setting. In the comparison group (n = 37), 13 patients with stage I to II cancer underwent surgery; 18 patients with stage III to IV cancer underwent chemotherapy; and 6 patients with stage III to IV cancer were not actively treated. The survival curves for RFA, surgery, and chemotherapy in these patients were calculated using Kaplan–Meier method.

Results

Median survival times for patients treated with (1) surgery alone and (2) RFA alone for stage I to II lung cancer were 33.8 and 28.2 months, respectively (P = 0.426). Median survival times for patients treated with (1) chemotherapy alone and (2) RFA with chemotherapy for stage III to IV cancer were 29 and 42 months, respectively (P = 0.03).

Conclusion

RFA can be used as an alternative treatment to surgery for older NSCLC patients with stage I to II inoperable cancer and can play a role as adjuvant therapy with chemotherapy for patients with stage III to IV lung cancer.

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Conflict of interest

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Authors and Affiliations

  1. Department of Radiology, Seoul Medical Center, Seoul, 134-740, South Korea

    Heon Lee

  2. Department of Radiology, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonbuk, 561-712, South Korea

    Gong Yong Jin, Young Min Han & Gyung Ho Chung

  3. Department of Internal Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonbuk, 561-712, South Korea

    Yong Chul Lee

  4. Department of Preventive Medicine, Research Institute of Clinical Medicine, Chonbuk National University Medical School, Jeonbuk, 561-712, South Korea

    Keun Sang Kwon

  5. Department of Radiology, National Jewish Health, Interstitial and Autoimmune Lung Disease Program, Denver, CO, 80206, USA

    David Lynch

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  1. Heon Lee
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  2. Gong Yong Jin
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  3. Young Min Han
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  4. Gyung Ho Chung
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  5. Yong Chul Lee
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  7. David Lynch
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Correspondence to Gong Yong Jin.

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Lee, H., Jin, G.Y., Han, Y.M. et al. Comparison of Survival Rate in Primary Non-Small-Cell Lung Cancer Among Elderly Patients Treated With Radiofrequency Ablation, Surgery, or Chemotherapy. Cardiovasc Intervent Radiol 35, 343–350 (2012). https://doi.org/10.1007/s00270-011-0194-y

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  • DOI: https://doi.org/10.1007/s00270-011-0194-y

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