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Mortality analyses of elderly patients with proximal femoral fracture during the pandemic: vaccination affects or not

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Abstract

Purpose

To evaluate the mortality rate, intensive care unit (ICU) referral, and Charlson comorbidity index (CCI) between different types of vaccinated and non-vaccinated patients operated on due to intertrochanteric femoral fracture (IFF) during the pandemic.

Methods

Ninety-six patients (43 males, 53 females) who had proximal femur nails (PFN) for the IFF during the pandemic were included in the study. The patients were divided into four subgroups; non-vaccinated, and different types of vaccinated. Mortality rates, ICU referrals, and CCI relations were evaluated.

Results

No significant difference was observed in terms of demographic data such as age, gender, side, CCI, and ICU referrals between the subgroups (p = 0.164, p = 0.546, p = 0.703, p = 0.771, p = 0.627 respectively). The mortality rate was significantly lower in the Sinovac + BioNTech subgroup (p = 0.044).

Conclusion

No relationship was found between mortality rate, ICU referral, and CCI in different types of vaccinated and non-vaccinated patient subgroups.

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Data availability

Applicable.

Code availability

Not applicable.

References

  1. Nicola M, Alsafi Z, Sohrabi C et al (2020) The socio-economic implications of the coronavirus pandemic (COVID-19): a review. Int J Surg 78:185–193. https://doi.org/10.1016/j.ijsu.2020.04.018

    Article  PubMed  PubMed Central  Google Scholar 

  2. Kumar Jain V, Lal H, Kumar Patralekh M, Vaishya R (2020) Fracture management during COVID-19 pandemic: a systematic review. J Clin Orthop Trauma 11(Suppl 4):S431–S441. https://doi.org/10.1016/j.jcot.2020.06.035

    Article  PubMed  PubMed Central  Google Scholar 

  3. Bayrak A, Duramaz A, Çakmur BB et al (2021) The effect of COVID-19 positivity on inflammatory parameters and thirty day mortality rates in patients over sixty five years of age with surgically treated intertrochanteric fractures. Int Orthop 45(12):3025–3031. https://doi.org/10.1007/s00264-021-05201-3

    Article  PubMed  Google Scholar 

  4. Yu MKL, Chan SHS, Cheng S et al (2023) Hesitancy, reactogenicity and immunogenicity of the mRNA and whole-virus inactivated Covid-19 vaccines in pediatric neuromuscular diseases. Hum Vaccin Immunother 19(1):2206278. https://doi.org/10.1080/21645515.2023.2206278

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Katoto PD, Tamuzi JL, Brand AS et al (2023) Effectiveness of COVID-19 Pfizer-BioNTech (BNT162b2) mRNA vaccination in adolescents aged 12–17 years: a systematic review and meta-analysis. Hum Vaccin Immunother 19(1):2214495. https://doi.org/10.1080/21645515.2023.2214495

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  6. https://covid19asi.saglik.gov.tr/EN-78317/turkish-national-covid-19-vaccine-administration-strategy.html

  7. https://covid19asi.saglik.gov.tr/?_Dil=2

  8. https://www.saglik.gov.tr/TR%2C78148/ilk-koronavirus-asisi-saglik-bakani-fahrettin-kocaya-yapildi.html

  9. Burahee AS, Barry VE, Sutcliffe RP, Mahroof S (2021) Older patients with proximal femur fractures and SARS-CoV-2 infection - An observational study. SICOT J 7:5. https://doi.org/10.1051/sicotj/2021001

    Article  PubMed  PubMed Central  Google Scholar 

  10. Jang SY, Cha Y, Kim Y, Kim KJ, Kim H, Choy W (2023) Analysis of the effects of COVID-19 on hip fractures in Korea without lockdown: ınterrupted time series analysis using a nationwide cohort. J Korean Med Sci. 38(18):e137. https://doi.org/10.3346/jkms.2023.38.e137

    Article  PubMed  PubMed Central  Google Scholar 

  11. Khabiri SS, Nabian MH, Zeynolabedin H et al (2020) Changes in fracture epidemiology due to COVID-19 crisis; a letter to editor. Arch Acad Emerg Med 8(1):63

    PubMed  PubMed Central  Google Scholar 

  12. Fiolet T, Kherabi Y, MacDonald CJ, Ghosn J, Peiffer-Smadja N (2022) Comparing COVID-19 vaccines for their characteristics, efficacy and effectiveness against SARS-CoV-2 and variants of concern: a narrative review. Clin Microbiol Infect 28(2):202–221. https://doi.org/10.1016/j.cmi.2021.10.005

    Article  CAS  PubMed  Google Scholar 

  13. HadjHassine I (2022) Covid-19 vaccines and variants of concern: a review. Rev Med Virol 32(4):e2313. https://doi.org/10.1002/rmv.2313

    Article  CAS  Google Scholar 

  14. Chilamakuri R, Agarwal S (2021) COVID-19: characteristics and therapeutics. Cells 10(2):206. https://doi.org/10.3390/cells10020206

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  15. Meo SA, Fahad Al-Jassir F, Al-Qahtani S, Albarrak R, Usmani AM, Klonoff DC (2021) Effect of Pfizer/BioNTech and Oxford/AstraZeneca vaccines against COVID-19 morbidity and mortality in real-world settings at countrywide vaccination campaign in Saudi Arabia. Eur Rev Med Pharmacol Sci. 25(22):7185–7191. https://doi.org/10.26355/eurrev_202111_27271

    Article  CAS  PubMed  Google Scholar 

  16. Polack FP, Thomas SJ, Kitchin N, C4591001 Clinical Trial Group et al (2020) Safety and efficacy of the BNT162b2 mRNA Covid-19 vaccine. N Engl J Med. 383(27):2603–2615. https://doi.org/10.1056/NEJMoa2034577

    Article  CAS  PubMed  Google Scholar 

  17. Britton A, Jacobs Slifka KM, Edens C et al (2021) Effectiveness of the Pfizer-BioNTech COVID-19 vaccine among residents of two skilled nursing facilities experiencing COVID-19 outbreaks - Connecticut, December 2020-February 2021. MMWR Morb Mortal Wkly Rep. 70(11):396–401. https://doi.org/10.15585/mmwr.mm7011e3

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Haas EJ, Angulo FJ, McLaughlin JM et al (2021) Impact and effectiveness of mRNA BNT162b2 vaccine against SARS-CoV-2 infections and COVID-19 cases, hospitalisations, and deaths following a nationwide vaccination campaign in Israel: an observational study using national surveillance data. Lancet 397(10287):1819–1829. https://doi.org/10.1016/S0140-6736(21)00947-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  19. Watson OJ, Barnsley G, Toor J, Hogan AB, Winskill P, Ghani AC (2022) Global impact of the first year of COVID-19 vaccination: a mathematical modelling study. Lancet Infect Dis 22(9):1293–1302. https://doi.org/10.1016/S1473-3099(22)00320-6

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Ritchie H, Mathieu E, Rodes-Guirao L, et al (2020) Coronavirus pandemic (COVİD-19). Our World in Data. https://ourworldindata.org/coronavirus

  21. Wouters OJ, Shadlen KC, Salcher-Konrad M et al (2021) Challenges in ensuring global access to COVID-19 vaccines: production, affordability, allocation, and deployment. Lancet 397(10278):1023–1034. https://doi.org/10.1016/S0140-6736(21)00306-8

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  22. Machingaidze S, Wiysonge CS (2021) Understanding COVID-19 vaccine hesitancy. Nat Med 27(8):1338–1339. https://doi.org/10.1038/s41591-021-01459-7

    Article  CAS  PubMed  Google Scholar 

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Authors

Contributions

All the authors have approved the final contents of the submission and been actively involved in the planning and in enactment of the study.

Corresponding author

Correspondence to Alkan Bayrak.

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Declarations

The study entitled ‘Mortality analyses of elderly patients with proximal femoral fracture during pandemic: vaccination affects or not’ was performed in the Bakırköy Dr. Sadi Konuk Training and Research Hospital, Department of Orthopedics and Traumatology, Istanbul, Turkey. The manuscript submitted does not contain information about medical device(s)/drug(s).

Ethics approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

Bakırköy Dr. Sadi Konuk Training and Research Hospital Ethics Committee, Ethical Approval (IRB protocol code: 2021/264, application ID: 2022–17-03).

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Bayrak, A., Tıngır, M., Aslantaş, F.Ç. et al. Mortality analyses of elderly patients with proximal femoral fracture during the pandemic: vaccination affects or not. International Orthopaedics (SICOT) 48, 331–335 (2024). https://doi.org/10.1007/s00264-023-05966-9

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  • DOI: https://doi.org/10.1007/s00264-023-05966-9

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