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Tumor microenvironment and lymphocyte infiltration

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Abstract

There is ample evidence that the presence of tumor-infiltrating T lymphocytes is associated with a favorable prognostic in patients. These observations suggest that a limiting step to immune resistance and immunotherapy could be the capacity of tumor-specific T cells to reach tumor bed. In this article, we review some factors that may influence this infiltration, and in particular the nature of the vasculature, the expression of chemokines or tumor antigens and the presence of dendritic cells and CD4+ T lymphocytes.

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Acknowledgments

The authors thank Pierre Coulie, Oberdan Leo and Kris Thielemans for careful review and interesting suggestions. The Laboratory of Immunobiology is supported by grants of the Fonds National de la Recherche Scientifique (FNRS)/Télévie, by the Walloon Region (Programme d’excellence CIBLES). G.R. is supported by the Fondation Rose et Jean Hoguet.

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The authors declare no conflict of interest.

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  1. Laboratory of Immunobiology, Department of Molecular Biology, Université Libre de Bruxelles, Rue des Pr Jeener et Brachet, 12, 6041, Gosselies, Belgium

    Gwendoline Rahir & Muriel Moser

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  1. Gwendoline Rahir
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Correspondence to Muriel Moser.

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Rahir, G., Moser, M. Tumor microenvironment and lymphocyte infiltration. Cancer Immunol Immunother 61, 751–759 (2012). https://doi.org/10.1007/s00262-012-1253-1

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