Skip to main content

Advertisement

Springer Nature Link
Log in

Prognostic value of CD208-positive cell infiltration in gastric cancer

  • Original Article
  • Published:
Cancer Immunology, Immunotherapy Aims and scope Submit manuscript

Abstract

Background and aim

A new marker, CD208, was recently explored as a mature interdigitating dendritic cell (DC), and the correlation between the infiltration of CD208-positive cells and clinical factors has been reported in various types of cancers. In this study, we tried to clarify the clinical implication of CD208-positive cell infiltration in gastric cancer immunohistochemically.

Patients and methods

A total of 128 gastric cancer patients who underwent a curative operation were enrolled. DCs in tumor nests were identified with two DC markers, CD208 and S-100 protein (S100), by immunohistochemistry. The correlation between clinicopathological features and the CD208- or S100-positive cell infiltration degree was analyzed.

Results

Infiltration of S100-positive cells did not correlate with the degree of CD208-positive cell infiltration. Patients with high CD208-positive cell infiltration in the peritumor had a poorer surgical outcome than those with low CD208 infiltration (p < 0.05). Multivariate analysis revealed that CD208-positive cell infiltration was not an independent prognostic factor.

Conclusion

We showed that intratumoral CD208-positive cells, as mature DCs, had an inverse correlation to patients’ postoperative outcome in gastric cancer, unlike a conventional DC marker. Evaluation of CD208-positive cell infiltration with S100-positive cell infiltration in gastric cancer is useful to predict antitumor immunological conditions in gastric cancer.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5

Similar content being viewed by others

References

  1. Maruyama K, Sasako M, Kinoshita T, Sano T, Katai H (1996) Surgical treatment for gastric cancer: the Japanese approach. Semin Oncol 23:360–368

    CAS  PubMed  Google Scholar 

  2. Sasako M, Saka M, Fukagawa T, Katai H, Sano T (2006) Modern surgery for gastric cancer—Japanese perspective. Scand J Surg 95:232–235

    CAS  PubMed  Google Scholar 

  3. Orita H, Matsusaka T, Wakasugi K, Kume K, Fujinaga Y, Fuchigami T, Iwashita A (1992) Clinicopathologic evaluation of recurrence in early gastric cancer. Surg Today 22:19–23

    Article  CAS  PubMed  Google Scholar 

  4. Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Iwashige H, Aridome K, Hokita S, Aikou T (2001) Invariant chain expression in gastric cancer. Cancer Lett 168:87–91

    Article  CAS  PubMed  Google Scholar 

  5. Ishigami S, Natsugoe S, Tokuda K, Nakajo A, Okumura H, Matsumoto M, Miyazono F, Hokita S, Aikou T (2003) Tumor-associated macrophage (TAM) infiltration in gastric cancer. Anticancer Res 23(5A):4079–4083

    CAS  PubMed  Google Scholar 

  6. Ishigami S, Natsugoe S, Matsumoto M, Okumura H, Sakita H, Nakashima S, Takao S, Aikou T (2003) Clinical implications of intratumoral dendritic cell infiltration in esophageal squamous cell carcinoma. Oncol Rep 10:1237–1240

    PubMed  Google Scholar 

  7. Ishigami S, Aikou T, Natsugoe S, Hokita S, Iwashige H, Tokushige M, Sonoda S (1998) Prognostic value of HLA-DR expression and dendritic cell infiltration in gastric cancer. Oncology 55:65–69

    Article  CAS  PubMed  Google Scholar 

  8. Hillenbrand EE, Neville AM, Coventry BJ (1999) Immunohistochemical localization of CD1a-positive putative dendritic cells in human breast tumours. Br J Cancer 79(5–6):940–944

    Article  CAS  PubMed  Google Scholar 

  9. Dallal RM, Christakos P, Lee K, Egawa S, Son YI, Lotze MT (2002) Paucity of dendritic cells in pancreatic cancer. Surgery 131:135–138

    Article  PubMed  Google Scholar 

  10. Ambe K, Mori M, Enjoji M (1999) S-100 protein-positive dendritic cells in colorectal adenocarcinomas. Distribution and relation to the clinical prognosis. Cancer 63:496–503

    Article  Google Scholar 

  11. Nakakubo Y, Miyamoto M, Cho Y, Hida Y, Oshikiri T, Suzuoki M, Hiraoka K, Itoh T, Kondo S, Katoh H (2003) Clinical significance of immune cell infiltration within gallbladder cancer. Br J Cancer 89:1736–1742

    Article  CAS  PubMed  Google Scholar 

  12. de Saint-Vis B, Vincent J, Vandenabeele S, Vanbervliet B, Pin JJ, Aït-Yahia S, Patel S, Mattei MG, Banchereau J, Zurawski S, Davoust J, Caux C, Lebecque S (1998) A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment. Immunity 9:325–336

    Article  PubMed  Google Scholar 

  13. Salaun B, de Saint-Vis B, Clair-Moninot V, Pin JJ, Barthélemy-Dubois C, Kissenpfennig A, Peronne C, Bates E, Mattei MG, Lebecque S (2003) Cloning and characterization of the mouse homologue of the human dendritic cell maturation marker CD208/DC-LAMP. Eur J Immunol 33:2619–2629

    Article  CAS  PubMed  Google Scholar 

  14. Sandel MH, Dadabayev AR, Menon AG, Morreau H, Melief CJ, Offringa R, van der Burg SH, Janssen-van Rhijn CM, Ensink NG, Tollenaar RA, van de Velde CJ, Kuppen PJ (2005) Prognostic value of tumor-infiltrating dendritic cells in colorectal cancer: role of maturation status and intratumoral localization. Clin Cancer Res 11:2576–2582

    Article  CAS  PubMed  Google Scholar 

  15. Treilleux I, Blay JY, Bendriss-Vermare N, Ray-Coquard I, Bachelot T, Guastalla JP, Bremond A, Goddard S, Pin JJ, Barthelemy-Dubois C, Lebecque S (2004) Dendritic cell infiltration and prognosis of early stage breast cancer. Clin Cancer Res 10:7466–7474

    Article  CAS  PubMed  Google Scholar 

  16. Japanese Gastric Cancer Association (1998) Japanese Classification of Gastric Carcinoma, 2nd English edition. Gastric Cancer 1:10–24

    Article  PubMed  Google Scholar 

  17. Galon J, Costes A, Sanchez-Cabo F, Kirilovsky A, Mlecnik B, Lagorce-Pagès C, Tosolini M, Camus M, Berger A, Wind P, Zinzindohoué F, Bruneval P, Cugnenc PH, Trajanoski Z, Fridman WH, Pagès F (2006) Type, density, and location of immune cells within human colorectal tumors predict clinical outcome. Science 313(5795):1960–1964

    Article  CAS  PubMed  Google Scholar 

  18. Ladányi A, Kiss J, Somlai B, Gilde K, Fejos Z, Mohos A, Gaudi I, Tímár J (2007) Density of DC-LAMP(+) mature dendritic cells in combination with activated T lymphocytes infiltrating primary cutaneous melanoma is a strong independent prognostic factor. Cancer Immunol Immunother 56:1459–1469

    Article  PubMed  Google Scholar 

  19. Elliott B, Scolyer RA, Suciu S, Lebecque S, Rimoldi D, Gugerli O, Musat E, Sharma RN, Lienard D, Keilholz U, Testori A, Eggermont A, MacKie R, Robert C, Cook M, Thompson JF, Angevin E, Spatz A (2007) A long-term protective effect of mature DC-LAMP+ dendritic cell accumulation in sentinel lymph nodes containing micrometastatic melanoma. European Organization for Research and Treatment of Cancer Melanoma Group. Clin Cancer Res 13:3825–3830

    Article  CAS  PubMed  Google Scholar 

  20. van Seters M, Beckmann I, Heijmans-Antonissen C, van Beurden M, Ewing PC, Zijlstra FJ, Helmerhorst TJ, KleinJan A (2008) Disturbed patterns of immunocompetent cells in usual-type vulvar intraepithelial neoplasia. Cancer Res 68:6617–6622

    Article  PubMed  Google Scholar 

  21. Yuan A, Steigen SE, Goll R, Vonen B, Husbekk A, Cui G, Florholmen J (2008) Dendritic cell infiltration pattern along the colorectal adenoma-carcinoma sequence. APMIS 116:445–456

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Digestive Surgery Surgical Oncology, Kagoshima University School of Medicine, 8-35-1 Sakuragaoka, Kagoshima, 890-8520, Japan

    Sumiya Ishigami, Shinichi Ueno, Masataka Matsumoto, Hiroshi Okumura, Takaaki Arigami, Yasuto Uchikado, Tetsuro Setoyama, Hideo Arima, Ken Sasaki, Masaki Kitazono, Hiroyuki Shinchi, Yuko Kijima & Shoji Natsugoe

Authors
  1. Sumiya Ishigami
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. Shinichi Ueno
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. Masataka Matsumoto
    View author publications

    You can also search for this author inPubMed Google Scholar

  4. Hiroshi Okumura
    View author publications

    You can also search for this author inPubMed Google Scholar

  5. Takaaki Arigami
    View author publications

    You can also search for this author inPubMed Google Scholar

  6. Yasuto Uchikado
    View author publications

    You can also search for this author inPubMed Google Scholar

  7. Tetsuro Setoyama
    View author publications

    You can also search for this author inPubMed Google Scholar

  8. Hideo Arima
    View author publications

    You can also search for this author inPubMed Google Scholar

  9. Ken Sasaki
    View author publications

    You can also search for this author inPubMed Google Scholar

  10. Masaki Kitazono
    View author publications

    You can also search for this author inPubMed Google Scholar

  11. Hiroyuki Shinchi
    View author publications

    You can also search for this author inPubMed Google Scholar

  12. Yuko Kijima
    View author publications

    You can also search for this author inPubMed Google Scholar

  13. Shoji Natsugoe
    View author publications

    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence to Sumiya Ishigami.

Rights and permissions

Reprints and permissions

About this article

Cite this article

Ishigami, S., Ueno, S., Matsumoto, M. et al. Prognostic value of CD208-positive cell infiltration in gastric cancer. Cancer Immunol Immunother 59, 389–395 (2010). https://doi.org/10.1007/s00262-009-0758-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00262-009-0758-8

Keywords