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Bacterial osteomyelitis in pediatric patients: a comprehensive review

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Abstract

Bacterial osteomyelitis, an inflammatory response in the bone caused by microorganisms, typically affects the metaphysis in the skeletally immature. Bacterial osteomyelitis possesses a significant diagnostic challenge in pediatric patients due to its nonspecific clinical presentation. Because the metaphysis is the primary focus of infection in skeletally immature patients, understanding the normal physiologic, maturation process of bones throughout childhood allows to understand the pathophysiology of osteomyelitis. Timely and accurate diagnosis is crucial to initiate appropriate treatment, and prevent long-term sequelae and efforts must be made to isolate the causative organism. The potential causative organism changes according to the age of the patient and underlying medical conditions. Staphylococcus Aureus is the most common isolated bacteria in pediatric pyogenic osteomyelitis whereas Kingella Kingae is the most common causative agent in children aged 6 months to 4 years. Imaging plays a pivotal role in the diagnosis, characterization, evaluation of complications, and follow up of bacterial osteomyelitis. Imaging also plays a pivotal role in the evaluation of potential neoplastic and non-neoplastic mimickers of osteomyelitis. In children, MRI is currently the gold standard imaging modality when suspecting bacterial osteomyelitis, whereas surgical intervention may be required in order to isolate the microorganism, treat complications, and exclude mimickers.

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Authors and Affiliations

  1. Radiology Department, Nicklaus Children’s Hospital, 3100 SW 62nd Ave, Miami, FL, 33155, USA

    Ricardo Restrepo, Halley J. Park, S. Pinar Karakas, Luisa F. Cervantes & Felipe G. Rodriguez-Ruiz

  2. Krieger School of Arts and Sciences, Johns Hopkins University, Baltimore, MD, USA

    Anna Maria Zahrah

  3. Radiology Department, Hospital Sant Joan de Deu, Barcelona, Spain

    Emilio J. Inarejos - Clemente

  4. Infectious Disease Department, Nicklaus Children’s Hospital, Miami, USA

    Marcelo Laufer

  5. Orthopedic, Sports Medicine, and Spine Institute, Nicklaus Children’s Hospital, Miami, USA

    Verena M. Shreiber

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  1. Ricardo Restrepo
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Restrepo, R., Park, H.J., Karakas, S. et al. Bacterial osteomyelitis in pediatric patients: a comprehensive review. Skeletal Radiol (2024). https://doi.org/10.1007/s00256-024-04639-x

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