Abstract
We reported a case of atypical spinal tuberculosis on the posterior elements of lumbar spine in a 52-year-old female. It was easy to be misdiagnosed as spinal tumor due to its imaging characteristics. We performed puncture biopsy to initially consider tuberculosis, and then the patient was accepted surgical treatment. The intraoperative removed specimen was sent to pathological examination, microbial culture, Xpert MTB/RIF and metagenomic next-generation sequencing (mNGS) and then the diagnosis of neural arch tuberculosis was confirmed. After operation, the patient obtained stable effect by anti-tuberculosis drug treatment. In a word, the uncommon case had an important reference significance for the diagnosis of atypical spine tuberculosis and differentiation from spinal tumors. It is critical to make right preliminary diagnosis by appropriate examination as it determined the next diagnosis and treatment in special and rare clinical cases.
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References
Dunn RN, Ben HM. Spinal tuberculosis: review of current management. Bone Joint J. 2018;100-B(4):425–31.
Garg RK, Somvanshi DS. Spinal tuberculosis: a review. J Spinal Cord Med. 2011;34(5):440–54.
Khanna K, Sabharwal S. Spinal tuberculosis: a comprehensive review for the modern spine surgeon. Spine J. 2019;19(11):1858–70.
Boruah DK, Gogoi BB, Prakash A, Lal NR, Hazarika K, Borah KK. Magnetic resonance imaging evaluation of posterior spinal tuberculosis: a cross-sectional study. Acta Radiol. 2021;62(8):1035–44. https://doi.org/10.1177/0284185120948496.
Pande KC, Babhulkar SS. Atypical spinal tuberculosis. Clin Orthop Relat Res. 2002;398:67–74.
Cao S, Gao X, Bai G, Xin B, Wang T, Cao J, et al. Development and Validation of a Scoring System for Differential Diagnosis of Tuberculosis and Metastatic Tumor in the Spine. Infect Drug Resist. 2021;14:407–13.
Strauss LG. Fluorine-18 deoxyglucose and false-positive results: a major problem in the diagnostics of oncological patients. Eur J Nucl Med. 1996;23(10):1409–15.
Avril N, Rosé CA, Schelling M, Dose J, Kuhn W, Bense S, et al. Breast imaging with positron emission tomography and fluorine-18 fluorodeoxyglucose: use and limitations. J Clin Oncol. 2000;18(20):3495–502.
Yu Y, Wang X, Du B, Yuan W, Ni B, Chen D. Isolated atypical spinal tuberculosis mistaken for neoplasia: case report and literature review. Eur Spine J. 2013;22(Suppl 3):S302–5.
Jain AK, Rajasekaran S, Jaggi KR, Myneedu VP. Tuberculosis of the Spine. J Bone Joint Surg Am. 2020;102(7):617–28.
Jin YH, Shi SY, Zheng Q, Shen J, Ying XZ, Wang YF. Application value of Xpert MTB/RIF in diagnosis of spinal tuberculosis and detection of rifampin resistance. Zhongguo Gu Shang. 2017;30(9):787–91.
Zong K, Luo C, Zhou H, Jiang Y, Li S. Xpert MTB/RIF assay for the diagnosis of rifampicin resistance in different regions: a meta-analysis. BMC Microbiol. 2019;19(1):177.
Simner PJ, Miller S, Carroll KC. Understanding the Promises and Hurdles of Metagenomic Next-Generation Sequencing as a Diagnostic Tool for Infectious Diseases. Clin Infect Dis. 2018;66(5):778–88.
Gu W, Deng X, Lee M, Sucu YD, Arevalo S, Stryke D, et al. Rapid pathogen detection by metagenomic next-generation sequencing of infected body fluids. Nat Med. 2021;27(1):115–24.
Zheng Y, Qiu X, Wang T, Zhang J. The Diagnostic Value of Metagenomic Next-Generation Sequencing in Lower Respiratory Tract Infection. Front Cell Infect Microbiol. 2021;11. https://doi.org/10.3389/fcimb.2021.694756.
Funding
This work was funded by the Hunan Province Natural Science Foundation of China (No. 2020JJ4913), Research project on postgraduate education and teaching reform of Central South University (No.2021JGB082), Graduate course ideological and political construction project of Central South University (No. 2022YJSKS032).
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Xiao, ST., Zhang, HQ. & Wang, YX. Isolated neural arch tuberculosis with tuberculomas: case report. Skeletal Radiol 53, 1417–1421 (2024). https://doi.org/10.1007/s00256-023-04450-0
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DOI: https://doi.org/10.1007/s00256-023-04450-0