Skip to main content
Springer Nature Link
Log in

Primary osseous sacral neuroblastoma in an adult

  • Case Report
  • Published:
Skeletal Radiology Aims and scope Submit manuscript

Abstract

Neoplasms of the sacrum are rare. Given the non-specific imaging findings in sacral lesions, the imaging-based differential diagnosis is always difficult. This case is about an adult with primary sacral neuroblastoma and we have discussed imaging and histopathological findings of this rare tumor.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Subscribe and save

Springer+ Basic
$34.99 /Month
  • Get 10 units per month
  • Download Article/Chapter or eBook
  • 1 Unit = 1 Article or 1 Chapter
  • Cancel anytime
Subscribe now

Buy Now

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2
Fig. 3
Fig. 4

Similar content being viewed by others

References

  1. Llauger J, Palmer J, Amores S, Bague S, Camins A. Primary tumors of the sacrum diagnostic imaging. Am J Roentgenol. 2000;174:417–24.

    Article  CAS  Google Scholar 

  2. Gerber S, Ollivier L, Leclere J, Vanel D, Missenard G, Brisse H, et al. Imaging of sacral tumors. Skelet Radiol. 2008;37(4):277–89.

    Article  CAS  Google Scholar 

  3. Disler DG, Miklic D. Imaging findings in tumors of the sacrum. Am J Roentgenol. 1999;173:1699–706.

    Article  CAS  Google Scholar 

  4. Ha AS, Chew FS. Imaging of sacral masses: self-assessment module. Am J Roentgenol. 2010;195:S32–6.

    Article  Google Scholar 

  5. Conter HJ, Gopalakrishnan V, Ravi V, Ater JL, Patel S, Araujo DM. Adult versus pediatric neuroblastoma: the MD Anderson Cancer Center experience. Sarcoma. 2014;2014, article ID 375151, 6 pages. https://doi.org/10.1155/2014/375151.

  6. Then C, Ebelt K, Langer A, Mayr D, Schmidmaier R, Oduncu F. Neuroblastoma in a 55-year-old patient: a case report. Case Rep Oncol. 2010;3(3):458–62.

    Article  PubMed  PubMed Central  Google Scholar 

  7. Marusawa H, Yamashita Y, Kajimura K, Kumegawa Y, Takaya H, Seto S, et al. A case of sacral neuroblastoma in an adult successfully treated with combination chemotherapy. Gan To Kagaku Ryoho. 1995;22(8):1115–8.

    CAS  PubMed  Google Scholar 

  8. Siegel R, Naishadham D, Jemal A. Cancer statistics 2012. CA Cancer J Clin. 2012;62(1):10–29.

    Article  PubMed  Google Scholar 

  9. Esiashvili N, Goodman M, Ward K, Marcus RB Jr, Johnstone PA. Neuroblastoma in adults: incidence and survival analysis based on SEER data. Pediatr Blood Cancer. 2007;49(1):41–6.

    Article  PubMed  Google Scholar 

  10. Cohn SL, Pearson AD, London WB, Moclair T, Ambros PF, Brodeur GM, et al. The international neuroblastoma risk group (INRG) classification system: an INRG task force report. J Clin Oncol. 2009;27(2):289–97.

    Article  PubMed  PubMed Central  Google Scholar 

  11. Kushner BH, Kramer K, LaQuaglia MP, Modak S, Cheung NK. Neuroblastoma in adolescents and adults: the Memorial Sloan-Kettering experience. Med Pediatr Oncol. 2003;41(6):508–15.

    Article  PubMed  Google Scholar 

  12. Narula M, Gupta N, Anand R, Kapoor S. Extraosseous Ewing’s sarcoma/primitive neuroectodermal tumor of the sacral nerve plexus. The Indian Journal of Radiology & Imaging. 2009;19(2):151–4.

    Article  CAS  Google Scholar 

  13. Hasegawa T, Hirose T, Ayala AG, Ito S, Tomaru U, Matsuno Y, et al. Adult neuroblastoma of the retroperitoneum and abdomen. Clinicopathologic distinction from primitive neuroectodermal tumor. Am J Surg Pathol. 2001;25(7):918–24.

    Article  CAS  PubMed  Google Scholar 

  14. Nour-Eldin NEA, Abdelmonem O, Tawfik AM, Naguib NNN, Klingebiel T, Rolle U, et al. Pediatric primary and metastatic neuroblastoma: MRI findings: pictorial review. Magn Reson Imaging. 2012;30(7):893–906.

    Article  PubMed  Google Scholar 

  15. Kocaoglu M, Frush DP. Pediatric presacral masses. RadioGraphics. 2006;26:833–57.

    Article  PubMed  Google Scholar 

  16. Bleeker G, Tytgat GA, Adam JA, Caron HN, Kremer LC, Hooft L, et al. 123 I-MIBG scintigraphy and 18F-FDG-PET imaging for diagnosing neuroblastoma. Cochrane Database Syst Rev. 2015;29(9):CD009263.

    Google Scholar 

  17. Smith L, Minter S, O’Brien P, Kraveka JM, Medina AM, Lazarchick J. Neuroblastoma in an adult: case presentation and literature review. Ann Clin Lab Sci. 2013;43(1):81–4.

    PubMed  Google Scholar 

  18. Kushner BH, LaQuaglia MP, Bonilla MA, Lindsley K, Rosenfield N, Yeh S, et al. Highly effective induction therapy for stage 4 neuroblastoma in children over 1 year of age. J Clin Oncol. 1994;12(12):2607–13.

    Article  CAS  PubMed  Google Scholar 

  19. Berthold F, Boos J, Burdach S, Erttmann R, Henze G, Hermann J, et al. Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial. Lancet Oncol. 2005;6(9):649–58.

    Article  CAS  PubMed  Google Scholar 

  20. Cheung NK, Cheung IY, Kushner BH, Ostrovnaya I, Chamberlain E, Kramer K, et al. Murine anti-GD2 monocloncal antibody 3F8 combined with granulocyte-macrophage colony-stimulating factor and 13-cis-retinoic acid in high-risk patients with stage 4 neuroblastoma in first remission. J Clin Oncol. 2012;30(26):3264–70.

    Article  CAS  PubMed  PubMed Central  Google Scholar 

Download references

Author information

Authors and Affiliations

  1. Musculoskeletal Imaging and Interventions Section, Mallinckrodt Institute of Radiology, Washington University School of Medicine, St. Louis, MO, USA

    Muhammad Naeem, Jonathan C. Baker & Jack W. Jennings

  2. Department of Pathology and Immunology, Washington University School of Medicine, St. Louis, MO, USA

    Horacio Maluf

  3. Division of Musculoskeletal Imaging and Interventions, Mallinckrodt Institute of Radiology, Washington University School of Medicine, Campus box 8131, 510 South Kingshighway Boulevard, Saint Louis, MO, 63110, USA

    Jack W. Jennings

Authors
  1. Muhammad Naeem
    View author publications

    You can also search for this author inPubMed Google Scholar

  2. Horacio Maluf
    View author publications

    You can also search for this author inPubMed Google Scholar

  3. Jonathan C. Baker
    View author publications

    You can also search for this author inPubMed Google Scholar

  4. Jack W. Jennings
    View author publications

    You can also search for this author inPubMed Google Scholar

Corresponding author

Correspondence to Jack W. Jennings.

Ethics declarations

Conflict of interest

The authors declare that they have no conflict of interest.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Naeem, M., Maluf, H., Baker, J.C. et al. Primary osseous sacral neuroblastoma in an adult. Skeletal Radiol 48, 985–988 (2019). https://doi.org/10.1007/s00256-018-3081-7

Download citation

  • Received:

  • Revised:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00256-018-3081-7

Keywords