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Chondroblastoma-like osteosarcoma: a case report and review

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Abstract

Chondroblastoma-like osteosarcomas are extremely rare malignancies having varying clinical, radiological and histological features. Their rarity causes challenges in both diagnosis and clinical management. They are often misdiagnosed as benign lesions. Their accurate diagnosis is important because they require adequate treatment. Misdiagnosed lesions or undertreatment may result in recurrences. We report a case of chondroblastoma-like osteosarcoma arising in the left first metatarsal bone with tarsometatarsal joint involvement in a 10-year-old boy for whom surgery with an original technique was planned after a multidisciplinary diagnostic review.

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References

  1. Fletcher CDM, Bridge JA, Hogendoorn PCW, Mertens F, editors. World Health Organization classification of tumours of soft tissue and bone. 4th ed. Lyon: IARC Press; 2013.

    Google Scholar 

  2. Klein MJ, Siegal GP. Osteosarcoma anatomic and histologic variants. Am J Clin Pathol. 2006;125(4):555–81.

    Article  PubMed  Google Scholar 

  3. Picci, P. (2007). Osteosarcoma (osteogenic sarcoma). Orphanet J Rare Dis,2(6).

  4. Schajowicz F, Próspero JD, Cosentino E. Case report 641. Skelet Radiol. 1990;19(8):603–6.

    Article  CAS  Google Scholar 

  5. Bacchini P, Inwards C, Biscaglia R, Picci P, Bertoni F. Chondroblastoma-like osteosarcoma. Orthopedics. 1999;22(3):337–9.

    CAS  PubMed  Google Scholar 

  6. Bahrami, A., Unni, K., Bertoni, F., Bacchini, P., Dorfman, H., Nojima, T., & Inwards, C. (2010, February). Chondroblastoma-Like Osteosarcoma: A Clinicopathologic Review of 17 Cases. In Laboratory investigation (Vol. 90, pp. 15A-15A). 75 Varick St, 9th flr, New York, NY 10013–1917 USA: Nature Publishing Group.

  7. Amit Byatnal, A., Rao, A. C., Solomon, M. C., & Radhakrishnan, R. A. (2013). A guise of osteosarcoma: Chondroblastoma-like. Indian Journal of Dental Research, 24(5).

  8. Biscaglia, R., Gasbarrini, A., Böhling, T., Bacchini, P., Bertoni, F., & Picci, P. (1998, September). Osteosarcoma of the bones of the foot—an easily misdiagnosed malignant tumor. In Mayo Clinic Proceedings (Vol. 73, No. 9, pp. 842–847). Elsevier.

  9. Greenspan A. Orthopedic imaging: a practical approach. Philadelphia: Lippincott Williams & Wilkins; 2011.

    Google Scholar 

  10. Casadei R, Ruggieri P, Moscato M, Ferraro A, Picci P. Aneurysmal bone cyst and giant cell tumor of the foot. Foot Ankle Int. 1996;17(8):487–95.

    Article  CAS  PubMed  Google Scholar 

  11. Schwartz, H., & Menendez, L. R. (2014). OKU, orthopaedic knowledge update: Musculoskeletal tumors 3. Amer Academy of Orthopaedic.

  12. Wu KK. Chondromyxoid fibroma of the foot bones. J Foot Ankle Surg. 1995;34(5):513–9.

    Article  CAS  PubMed  Google Scholar 

  13. Reinus WR, Gilula LA, Shirley SK, Askin FB, Siegal GP. Radiographic appearance of Ewing sarcoma of the hands and feet: report from the Intergroup Ewing Sarcoma Study. Am J Roentgenol. 1985;144(2):331–6.

    Article  CAS  Google Scholar 

  14. Anninga JK, Picci P, Fiocco M, Kroon HM, Vanel D, Alberghini M, et al. Osteosarcoma of the hands and feet: a distinct clinico-pathological subgroup. Virchows Arch. 2013;462(1):109–20.

    Article  PubMed  Google Scholar 

  15. Ogose A, Unni KK, Swee RG, May GK, Rowland CM, Sim FH. Chondrosarcoma of small bones of the hands and feet. Cancer. 1997;80(1):50–9.

    Article  CAS  PubMed  Google Scholar 

  16. Ollivier L, Vanel D, Leclère J. Review: Imaging of chondrosarcomas. Cancer Imaging. 2004;4(1):36.

    Article  PubMed Central  CAS  Google Scholar 

  17. Kyriakos M, Land VJ, Penning HL, Parker SG. Metastatic chondroblastoma. Report of a fatal case with a review of the literature on atypical, aggressive, and malignant chondroblastoma. Cancer. 1985;55(8):1770–89.

    Article  CAS  PubMed  Google Scholar 

  18. Hatcher CH, Campbell JC. Benign chondroblastoma of bone; its histologic variations and a report of late sarcoma in the site of one. Bull Hosp Jt Dis. 1951;12(2):411–30.

    CAS  Google Scholar 

  19. Steiner GC. Postradiation sarcoma of bone. Cancer. 1965;18(5):603–12.

    Article  CAS  PubMed  Google Scholar 

  20. Huvos AG, Higinbotham NL, Marcove RC, Oleary P. Aggressive chondroblastoma: review of the literature on aggressive behavior and metastases with a report of one new case. Clin Orthop Relat Res. 1977;126:266–72.

    PubMed  Google Scholar 

  21. Mirra, J. M., Picci, P., & Gold, R. H. (1989). Bone tumors: clinical, radiologic, and pathologic correlations.

  22. Elek EM, Grimer RJ, Mangham DC, Davies AM, Carter SR, Tillman RM. Malignant chondroblastoma of the os calcis. Sarcoma. 1998;2(1):45–8.

    Article  PubMed Central  CAS  PubMed  Google Scholar 

  23. Dahlin DC, Ivins JC. Benign chondroblastoma. A study of 125 cases. Cancer. 1972;30(2):401–13.

    Article  CAS  PubMed  Google Scholar 

  24. Ramappa AJ, Lee FY, Tang P, Carlson JR, Gebhardt MC, Mankin HJ. Chondroblastoma of bone. J Bone Joint Surg. 2000;82(8):1140–0.

  25. Jee WH, Park YK, McCauley TR, Choi KH, Ryu KN, Suh JS, et al. Chondroblastoma: MR characteristics with pathologic correlation. J Comput Assist Tomogr. 1999;23(5):721–6.

    Article  CAS  PubMed  Google Scholar 

  26. Oxtoby JW, Davies AM. MRI characteristics of chondroblastoma. Clin Radiol. 1996;51(1):22–6.

    Article  CAS  PubMed  Google Scholar 

  27. Rybak LD, Rosenthal DI, Wittig JC. Chondroblastoma: radiofrequency ablation-alternative to surgical resection in selected cases. Radiology. 2009;251(2):599.

    Article  PubMed  Google Scholar 

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Conflict of interest

The authors of this case report declare no conflict of interest.

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Authors and Affiliations

  1. Department of Musculoskeletal Oncology, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136, Bologna, Italy

    Osman Emre Aycan, Yavuz Arikan & Marco Manfrini

  2. Department of Pathology, Istituto Ortopedico Rizzoli, Via Pupilli 1, 40136, Bologna, Italy

    Daniel Vanel & Alberto Righi

Authors
  1. Osman Emre Aycan
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  2. Daniel Vanel
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  3. Alberto Righi
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  4. Yavuz Arikan
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  5. Marco Manfrini
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Correspondence to Daniel Vanel.

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Aycan, O.E., Vanel, D., Righi, A. et al. Chondroblastoma-like osteosarcoma: a case report and review. Skeletal Radiol 44, 869–873 (2015). https://doi.org/10.1007/s00256-014-2068-2

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  • DOI: https://doi.org/10.1007/s00256-014-2068-2

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