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Intraosseous schwannoma in schwannomatosis

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Abstract

This study investigates the clinical, radiological, and pathological features of two cases of intraosseous schwannoma that arose in patients with multiple soft tissue schwannomas. In both cases, the patients were adult females and the tibial bone was affected. Vestibular schwannomas were not identified, indicating that these were not cases of neurofibromatosis 2 (NF2). Radiographs showed a well-defined lytic lesion in the proximal tibia; in one case, this was associated with a pathological fracture. Histologically, both cases showed typical features of benign schwannoma. Molecular analysis of one of the excised tumors showed different alterations in the NF2 gene in keeping with a diagnosis of schwannomatosis. Our findings show for the first time that intraosseous schwannomas can occur in schwannomatosis.

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Acknowledgments

We would like to thank Chris Lowe for typing the manuscript. The authors acknowledge the support of the Oxford NIHR BRU.

Conflict of interest statement

The authors declare there is no conflict of interest.

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Authors and Affiliations

  1. Department of Pathology, Nuffield Department of Orthopaedics, Rheumatology and Musculoskeletal Sciences, University of Oxford, Nuffield Orthopaedic Centre, Oxford, OX3 7HE, UK

    T. G. Kashima, M. R. J. P. Gibbons, D. Whitwell, C. L. M. H. Gibbons, K. M. Bradley, S. J. Ostlere & N. A. Athanasou

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  1. T. G. Kashima
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  2. M. R. J. P. Gibbons
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  3. D. Whitwell
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  4. C. L. M. H. Gibbons
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  5. K. M. Bradley
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  6. S. J. Ostlere
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  7. N. A. Athanasou
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Correspondence to N. A. Athanasou.

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Kashima, T.G., Gibbons, M.R.J.P., Whitwell, D. et al. Intraosseous schwannoma in schwannomatosis. Skeletal Radiol 42, 1665–1671 (2013). https://doi.org/10.1007/s00256-013-1712-6

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  • DOI: https://doi.org/10.1007/s00256-013-1712-6

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