Abstract.
Continuous fermentations were conducted with in situ cell retention using spin filters (pore size 5 µm and 10 µm) for propionic acid production by Propionibacterium acidipropionici. Continuous fermentation with a 5-µm pore size spin filter resulted in 50% cell retention. Propionic acid productivity was enhanced (0.9 g l–1 h–1) by approximately four-fold compared to conventional batch fermentation (0.25 g l–1 h–1). The in situ cell retention (5-µm pore size spin filter) bioreactor was operated continuously and smoothly for 8 days at a dilution rate of D=0.05 h–1.
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Received revision: 13 November 2000
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Goswami, .V., Srivastava, .A. Propionic acid production in an in situ cell retention bioreactor. Appl Microbiol Biotechnol 56, 676–680 (2001). https://doi.org/10.1007/s002530000582
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DOI: https://doi.org/10.1007/s002530000582