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Biotechnological interventions and production of galanthamine in Crinum spp.

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Abstract

Genus Crinum L. is a member of the Amaryllidaceae family having beautiful, huge, ornamental plants with umbels of lily-like blooms that are found in tropical and subtropical climates all over the world. For thousands of years, Crinum has been used as a traditional medicine to treat illnesses and disorders. Numerous distinct alkaloids of the Amaryllidaceae group, whose most well-known properties include analgesic, anticholinergic, antitumor, and antiviral, have recently been discovered by phytochemical analyses. However, because of decades of overexploitation for their economically significant bioactive ingredients and poor seed viability and germination rates, these plants are now threatened in their native environments. Because of these factors, researchers are investigating micropropagation techniques to optimize phytochemicals in vitro. This review’s objective is to offer details on the distribution, phytochemistry, micropropagation, in vitro galanthamine synthesis, and pharmacology which will help to design biotechnological techniques for the preservation, widespread multiplication, and required secondary metabolite production from Crinum spp.

Key points

• Botanical description and phytochemical profile of Crinum spp.

• In vitro micropropagation method of Crinum sp.

• Bioactive compound galanthamine isolation techniques and its pharmacological properties.

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Acknowledgments

The authors are grateful to the National Medicinal Plants Board, Ministry of AYUSH, Government of India for providing financial support (grant number NMPB/IFD/GIA/NR/PL/2018-19/187) for in vitro conservation of medicinal plants.

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Authors and Affiliations

  1. Department of Botany, Bhairab Ganguly College (affiliated to West Bengal State University), Kolkata, West Bengal, 700056, India

    Rupa Sanyal, Sharmila Pandey & Saheli Nandi

  2. Department of Botany, Siddha Clinical Research Unit, Central Council for Research in Siddha, Palayamkottai, Tamil Nadu, Chennai, 627002, India

    Manokari M.

  3. Department of Life Sciences, Presidency University, College Street, Kolkata, 700073, India

    Protha Biswas & Abhijit Dey

  4. Advanced Pharmacognosy Research Laboratory, Department of Pharmaceutical Technology, Jadavpur University, Kolkata, West Bengal, 700032, India

    Saikat Dewanjee

  5. Department of Biomedical Sciences, School of Bio Sciences and Technology, Vellore Institute of Technology (VIT), Vellore, Tamil Nadu, 632014, India

    Abilash Valsala Gopalakrishnan

  6. Department of Biotechnology, School of Engineering & Technology, Sharda University, Greater Noida, Uttar Pradesh, 201310, India

    Niraj Kumar Jha & Saurabh Kumar Jha

  7. Department of Biotechnology Engineering and Food Technology, Chandigarh University, Mohali, 140413, India

    Niraj Kumar Jha & Saurabh Kumar Jha

  8. Department of Biotechnology, School of Applied & Life Sciences (SALS), Uttaranchal University, Dehradun, 248007, India

    Niraj Kumar Jha & Saurabh Kumar Jha

  9. Agricultural Research Station, Fort Valley State University, Fort Valley, GA, 31088, USA

    Nirmal Joshee

  10. Department of Biotechnology, Lovely Professional University Punjab, Phagwara, Punjab, India

    Devendra Kumar Pandey

  11. Biotechnology Unit, Kanchi Mamunivar Government Institute for Postgraduate Studies and Research, -605008, Puducherry, India

    Mahipal S. Shekhawat

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  1. Rupa Sanyal
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Contributions

RS, MM, SP, and SN wrote the primary draft. PB, SD, AVG, and NKJ revised the draft. SKJ and NJ prepared the tables. DKP, AD, and MSS supervised and guided the whole work.

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Correspondence to Abhijit Dey or Mahipal S. Shekhawat.

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Sanyal, R., M., M., Pandey, S. et al. Biotechnological interventions and production of galanthamine in Crinum spp.. Appl Microbiol Biotechnol 107, 2155–2167 (2023). https://doi.org/10.1007/s00253-023-12444-0

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