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Constitutive calcium entry and cancer: updated views and insights

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Abstract

Tight control of basal cytosolic Ca2+ concentration is essential for cell survival and to fine-tune Ca2+-dependent cell functions. A way to control this basal cytosolic Ca2+ concentration is to regulate membrane Ca2+ channels including store-operated Ca2+ channels and secondary messenger-operated channels linked to G-protein-coupled or tyrosine kinase receptor activation. Orai, with or without its reticular STIM partner and Transient Receptor Potential (TRP) proteins, were considered to be the main Ca2+ channels involved. It is well accepted that, in response to cell stimulation, opening of these Ca2+ channels contributes to Ca2+ entry and the transient increase in cytosolic Ca2+ concentration involved in intracellular signaling. However, in various experimental conditions, Ca2+ entry and/or Ca2+ currents can be recorded at rest, without application of any experimental stimulation. This led to the proposition that some plasma membrane Ca2+ channels are already open/activated in basal condition, contributing therefore to constitutive Ca2+ entry. This article focuses on direct and indirect observations supporting constitutive activity of channels belonging to the Orai and TRP families and on the mechanisms underlying their basal/constitutive activities.

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Freely adapted from Saul et al. (2014)

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Abbreviations

ARC:

Arachidonate-regulated Ca2+

BKCa:

Big-conductance Ca2+-activated K+ channels

B-SOCE:

Basal store-operated calcium entry

CaV3.2:

Voltage-gated Ca2+ channel 3.2

CRAC:

Ca2+ release-activated Ca2+

GPCR:

G-protein-coupled receptor

hEAG1:

Human ether à go-go K+ channel 1

IKCa:

Intermediate conductance Ca2+-activated K+ channels

LPA:

Lysophosphatidic acid

LPC:

Lysophosphatidylcholine

NVG-Ca2+ channel:

Non-voltage-gated Ca2+ channel

P2X:

Purinergic ionotropic receptor

R-SOCE:

Receptor-triggered store-operated Ca2+ entry influx

SPCA:

Secretory pathway Ca2+-ATPase

SKCa:

Small-conductance Ca2+-activated K+ channels

SMOC:

Secondary messenger-operated channels

STIM:

Stromal interaction molecule

SAC:

Stretch-activated channels

SOC:

Store-operated channels

TRPC:

Transient receptor potential canonical

TRPM7:

Transient receptor potential melastatin-related 7

TRPV:

Transient receptor potential vanilloid

VOCC:

Voltage-operated calcium channels

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Acknowledgements

This work was supported by la Ligue Contre le Cancer (comités des régions Bretagne, Pays de la Loire, Centre, and Poitou-Charentes), Region Centre (LIPIDS project of ARD2020-Biomédicaments), Inserm, CNRS, Cancéropôle Grand Ouest, the association “CANCEN”, Tours’ Hospital oncology association ACORT, Fondation ARC, ANR (ANR-12-JSV2-0004-001), Biosit, University of Brest, University of Rennes 1, University of Poitiers, University of Tours, and Roche-SFD.

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  1. Olivier Mignen, Bruno Constantin, Marie Potier-Cartereau, Aubin Penna, Mathieu Gautier, and Christophe Vandier participated equally in the writing of this review.

Authors and Affiliations

  1. Inserm UMR 1078 IFR148 Université de Bretagne Occidentale, Brest, France

    Olivier Mignen, Paul Buscaglia & Marjolaine Debant

  2. STIM, ERL 7368 CNRS Université de Poitiers, Poitiers, France

    Bruno Constantin & Elsa Bayet

  3. Inserm/University of Tours U1069, Nutrition-Croissance et Cancer (N2C), 37032, Tours, France

    Marie Potier-Cartereau, Maxime Guéguinou, Romain Félix, Aurélie Chantôme & Christophe Vandier

  4. IRSET, Inserm U1085, University of Rennes 1, 36043, Rennes, France

    Aubin Penna, Kenji F. Shoji & Elsa Bayet

  5. EA4667, Université de Picardie Jules Verne, 80039, Amiens, France

    Mathieu Gautier

  6. EA 2216, Inserm ESPRI, ERI 29, Brest, France

    Yves Renaudineau & Marjolaine Debant

  7. Network “Ion Channels and Cancer-Canceropôle Grand Ouest”, (IC-CGO), Grand Ouest, France

    Olivier Mignen, Bruno Constantin, Marie Potier-Cartereau, Aubin Penna, Maxime Guéguinou, Yves Renaudineau, Kenji F. Shoji, Romain Félix, Elsa Bayet, Paul Buscaglia, Marjolaine Debant, Aurélie Chantôme & Christophe Vandier

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Special Issue: Ion Channels, Transporters, and Cancer.

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Mignen, O., Constantin, B., Potier-Cartereau, M. et al. Constitutive calcium entry and cancer: updated views and insights. Eur Biophys J 46, 395–413 (2017). https://doi.org/10.1007/s00249-017-1216-8

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