Abstract
Background
Lymphobronchial tuberculosis (TB) is tuberculous lymphadenopathy involving the airways, which is particularly common in children.
Objective
To describe CT findings of lymphobronchial TB in children, the parenchymal complications and associated abnormalities.
Materials and methods
CT scans of children with lymphobronchial TB were reviewed retrospectively. Lymphadenopathy, bronchial narrowing, parenchymal complications and associations were documented.
Results
Infants comprised 51% of patients. The commonest site of lymphadenopathy was the subcarinal mediastinum (97% of patients). Bronchial compression was seen in all children (259 bronchi, of these 28% the bronchus intermedius) with severe or complete stenosis in 23% of affected bronchi. Parenchymal complications were present in 94% of patients, including consolidation (88%), breakdown (42%), air trapping (38%), expansile pneumonia (28%), collapse (17%) and bronchiectasis (9%), all predominantly on the right side (63%). Associated abnormalities included ovoid lesions, miliary nodules, pleural disease and intracavitary bodies.
Conclusion
Airway compression was more severe in infants and most commonly involved the bronchus intermedius. Numerous parenchymal complications were documented, all showing right-side predominance.







Similar content being viewed by others
Explore related subjects
Discover the latest articles and news from researchers in related subjects, suggested using machine learning.References
WHO (2010) Global tuberculosis control: a short update to the 2009 report. http://www.who.int/tb/publications/global_report/2009/update/en/index.html Accessed on 22/3/2010
Marais BJ, Gie RP, Schaaf HS et al (2004) The natural history of childhood intra-thoracic tuberculosis: a critical review of literature from the pre-chemotherapy era. Int J Tuberc Lung Dis 8:392–402
Beyers JA (1979) The radiological features of primary pulmonary tuberculosis. S Afr Med J 55:994–997
Daltro PA, Nunez-Santos E (2008) Pediatric tuberculosis. In: Lucaya J, Strife JL (eds) Pediatric chest imaging: chest imaging in infants and children. Springer, Berlin, pp 165–181
Marais BJ, Gie RP, Schaaf HS et al (2004) A proposed radiological classification of childhood intra-thoracic tuberculosis. Pediatr Radiol 34:886–894
Goussard P, Gie R (2007) Airway involvement in pulmonary tuberculosis. Paediatr Respir Rev 8:118–123
Gie RP, Goussard P, Kling S et al (2004) Unusual forms of intrathoracic tuberculosis in children and their management. Paediatr Respir Rev 5 Suppl A:S139–S141
Andronikou S, Vanhoenacker FM, De Backer AI (2009) Advances in imaging chest tuberculosis: blurring of differences between children and adults. Clin Chest Med 30:717–744
Venta LA, Shapir J (1985) Enhancement of pulmonary vasculature in pulmonary consolidation as seen by computed tomography. J Comput Tomogr 9:133–135
Andronikou S, Wieslthaler N (2009) Imaging for tuberculosis in children. In: Schaaf HS, Zumla A (eds) Tuberculosis: a comprehensive clinical reference. Saunders Elsevier, Philadelphia, pp 261–295
Griffith-Richards SB, Goussard P, Andronikou S et al (2007) Cavitating pulmonary tuberculosis in children: correlating radiology with pathogenesis. Pediatr Radiol 37:798–804
Papagiannopoulos KA, Linegar AG, Harris DG et al (1999) Surgical management of airway obstruction in primary tuberculosis in children. Ann Thorac Surg 68:1182–1186
Hewitson JP, Von Oppell UO (1997) Role of thoracic surgery for childhood tuberculosis. World J Surg 21:468–474
Freixinet J, Varela A, Lopez RL et al (1995) Surgical treatment of childhood mediastinal tuberculous lymphadenitis. Ann Thorac Surg 59:644–646
Hammer GB, Fitzmaurice BG, Brodsky JB (1999) Methods for single-lung ventilation in pediatric patients. Anesth Analg 89:1426–1429
Respiration and circulation (biological handbooks) (1971) Federation of American Societies for Experimental Biology. Bethesda, MD, pp 105–108
Weibel ER (1963) Morphometry of the human lung. Springer, Berlin
The lung: scientific foundations (1997) (2nd edn) Lippincott-Raven, Philadelphia, pp 1064–1066
Middelkoop K, Bekker LG, Morrow C et al (2009) Childhood tuberculosis infection and disease: a spatial and temporal transmission analysis in a South African township. S Afr Med J 99:738–743
Parisi MT, Jensen MC, Wood BP (1994) Pictorial review of the usual and unusual roentgen manifestations of childhood tuberculosis. Clin Imaging 18:149–154
Andronikou S, Joseph E, Lucas S et al (2004) CT scanning for the detection of tuberculous mediastinal and hilar lymphadenopathy in children. Pediatr Radiol 34:232–236
de Charnace G, Delacourt C (2001) Diagnostic techniques in paediatric tuberculosis. Paediatr Respir Rev 2:120–126
Delacourt C, Mani TM, Bonnerot V et al (1993) Computed tomography with normal chest radiograph in tuberculous infection. Arch Dis Child 69:430–432
Venkateswaran RV, Barron DJ, Brawn WJ et al (2005) A forgotten old disease: mediastinal tuberculous lymphadenitis in children. Eur J Cardiothorac Surg 27:401–404
Andreu J, Caceres J, Pallisa E et al (2004) Radiological manifestations of pulmonary tuberculosis. Eur J Radiol 51:139–149
Mukund A, Khurana R, Bhalla AS et al (2011) CT patterns of nodal disease in pediatric chest tuberculosis. World J Radiol 3:17–23
Newton SM, Brent AJ, Anderson S et al (2008) Paediatric tuberculosis. Lancet Infect Dis 8:498–510
Palme IB, Gudetta B, Bruchfeld J et al (2002) Impact of human immunodeficiency virus 1 infection on clinical presentation, treatment outcome and survival in a cohort of Ethiopian children with tuberculosis. Pediatr Infect Dis J 21:1053–1061
Chintu C, Mudenda V, Lucas S et al (2002) Lung diseases at necropsy in African children dying from respiratory illnesses: a descriptive necropsy study. Lancet 360:985–990
Schaaf HS, Marais BJ, Whitelaw A et al (2007) Culture-confirmed childhood tuberculosis in Cape Town, South Africa: a review of 596 cases. BMC Infect Dis 7:140
Hesseling AC, Cotton MF, Jennings T et al (2009) High incidence of tuberculosis among HIV-infected infants: evidence from a South African population-based study highlights the need for improved tuberculosis control strategies. Clin Infect Dis 48:108–114
Leung AN, Muller NL, Pineda PR et al (1992) Primary tuberculosis in childhood: radiographic manifestations. Radiology 182:87–91
Papaioannou G, Young C, Owens CM (2007) Multidetector row CT for imaging the paediatric tracheobronchial tree. Pediatr Radiol 37:515–529
Maydell A, Goussard P, Andronikou S et al (2010) Radiological changes post-lymph node enucleation for airway obstruction in children with pulmonary tuberculosis. Eur J Cardiothorac Surg 38:478–483
Lawler LP, Corl FM, Haponik EF et al (2002) Multidetector row computed tomography and 3-dimensional volume rendering for adult airway imaging. Curr Probl Diagn Radiol 31:115–133
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Lucas, S., Andronikou, S., Goussard, P. et al. CT features of lymphobronchial tuberculosis in children, including complications and associated abnormalities. Pediatr Radiol 42, 923–931 (2012). https://doi.org/10.1007/s00247-012-2399-x
Received:
Revised:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00247-012-2399-x