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Extra-osseous involvement of Langerhans’ cell histiocytosis in children

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Abstract

The predominant clinical and radiological features of Langerhans’ cell histiocytosis (LCH) in children are due to osseous involvement. Extra-osseous disease is far less common, occurring in association with bone disease or in isolation; nearly all anatomical sites may be affected and in very various combinations. The following article is based on a multicentre review of 31 children with extra-osseous LCH. The objective is to summarise the diverse possibilities of organ involvement. The radiological manifestations using different imaging modalities are rarely pathognomonic on their own. Nevertheless, familiarity with the imaging findings, especially in children with systemic disease, may be essential for early diagnosis.

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Authors and Affiliations

  1. Departments of Radiology and Interventional Radiology, University Hospital Centre—CHUV, Lausanne, Switzerland

    Sabine Schmidt & François Gudinchet

  2. Department of Paediatric Radiology, Children’s Hospital, Zürich, Switzerland

    Georg Eich

  3. Department of Paediatric Radiology, Hôpital Cantonal, Geneva, Switzerland

    Sylviane Hanquinet

  4. Department of Paediatric Radiology, Children’s Hospital, Bern, Switzerland

    Heinz Tschäppeler

  5. Department of Paediatric Radiology, Children’s Hospital, St. Gallen, Switzerland

    Peter Waibel

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  1. Sabine Schmidt
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  2. Georg Eich
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  3. Sylviane Hanquinet
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  4. Heinz Tschäppeler
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  5. Peter Waibel
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  6. François Gudinchet
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Correspondence to Sabine Schmidt.

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Schmidt, S., Eich, G., Hanquinet, S. et al. Extra-osseous involvement of Langerhans’ cell histiocytosis in children. Pediatr Radiol 34, 313–321 (2004). https://doi.org/10.1007/s00247-003-1118-z

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  • DOI: https://doi.org/10.1007/s00247-003-1118-z

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