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Abnormal metabolic brain network associated with Parkinson’s disease: replication on a new European sample

  • Functional Neuroradiology
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Abstract

Purpose

The purpose of this study was to identify the specific metabolic brain pattern characteristic for Parkinson’s disease (PD): Parkinson’s disease-related pattern (PDRP), using network analysis of [18F]-fluorodeoxyglucose positron emission tomography (FDG-PET) brain images in a cohort of Slovenian PD patients.

Methods

Twenty PD patients (age 70.1 ± 7.8 years, Movement Disorder Society Unified Parkinson’s Disease Motor Rating Scale (MDS-UPDRS-III) 38.3 ± 12.2; disease duration 4.3 ± 4.1 years) and 20 age-matched normal controls (NCs) underwent FDG-PET brain imaging. An automatic voxel-based scaled subprofile model/principal component analysis (SSM/PCA) was applied to these scans for PDRP-Slovenia identification.

Results

The pattern was characterized by relative hypermetabolism in pallidum, putamen, thalamus, brain stem, and cerebellum associated with hypometabolism in sensorimotor cortex, posterior parietal, occipital, and frontal cortices. The expression of PDRP-Slovenia discriminated PD patients from NCs (p < 0.0001) and correlated positively with patients’ clinical score (MDS-UPDRS-III, p = 0.03). Additionally, its topography agrees well with the original PDRP (p < 0.001) identified in American cohort of PD patients. We validated the PDRP-Slovenia expression on additional FDG-PET scans of 20 PD patients, 20 NCs, and 25 patients with atypical parkinsonism (AP). We confirmed that the expression of PDRP-Slovenia manifests good diagnostic accuracy with specificity and sensitivity of 85–90% at optimal pattern expression cutoff for discrimination of PD patients and NCs and is not expressed in AP.

Conclusion

PDRP-Slovenia proves to be a robust and reproducible functional imaging biomarker independent of patient population. It accurately differentiates PD patients from NCs and AP and correlates well with the clinical measure of PD progression.

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Authors and Affiliations

  1. Department of Nuclear Medicine, University Medical Centre Ljubljana, Ljubljana, Slovenia

    Petra Tomše, Luka Jensterle, Marko Grmek & Katja Zaletel

  2. Department of Neurology, University Medical Centre Ljubljana, Zaloška cesta 2, 1000 Ljubljana, Slovenia

    Zvezdan Pirtošek & Maja Trošt

  3. Center for Neurosciences, The Feinstein Institute for Medical Research, Manhasset, NY, USA

    Vijay Dhawan, Shichun Peng, David Eidelberg & Yilong Ma

Authors
  1. Petra Tomše
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  2. Luka Jensterle
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  3. Marko Grmek
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  4. Katja Zaletel
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  5. Zvezdan Pirtošek
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  6. Vijay Dhawan
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  7. Shichun Peng
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  8. David Eidelberg
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  9. Yilong Ma
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  10. Maja Trošt
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Corresponding author

Correspondence to Maja Trošt.

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Funding

This work was supported by the Slovenian Research Agency (L3-4255). The work of YM, SP, VD and DE was supported by the NIH Morris K Udall Center of Excellence for Parkinson’s Disease Research (P50 NS071675).

Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in the studies involving human participants were in accordance with the ethical standards of the Slovenian Medical Ethics Committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Tomše, P., Jensterle, L., Grmek, M. et al. Abnormal metabolic brain network associated with Parkinson’s disease: replication on a new European sample. Neuroradiology 59, 507–515 (2017). https://doi.org/10.1007/s00234-017-1821-3

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