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Imaging spectrum of central nervous system complications of hematopoietic stem cell and solid organ transplantation.

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Abstract

Neurologic complications are common after hematopoietic stem cell transplantation (HSCT) and solid organ transplantation (SOT) and affect 30–60% of transplant recipients. The aim of this article is to provide a practical imaging approach based on the timeline and etiology of CNS abnormalities, and neurologic complications related to transplantation of specific organs. The lesions will be classified based upon the interval from HSCT procedure: pre-engraftment period <30 days, early post-engraftment period 30–100 days, late post-engraftment period >100 days, and the interval from SOT procedure: postoperative phase 1–4 weeks, early posttransplant syndromes 1–6 months, late posttransplant syndromes >6 months. Further differentiation will be based on etiology: infections, drug toxicity, metabolic derangements, cerebrovascular complications, and posttransplantation malignancies. In addition, differentiation will be based on complications specific to the type of transplantation: allogeneic and autologous hematopoietic stem cells (HSC), heart, lung, kidney, pancreas, and liver. Thus, in this article we emphasize the strategic role of neuroradiology in the diagnosis and response to treatment by utilizing a methodical approach in the work up of patients with neurologic complications after transplantation.

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References

  1. Pruitt AA, Graus F, Rosenfeld MR (2013) Neurological complications of transplantation: part I: hematopoietic cell transplantation. Neurohospitalist 3:24–38

    Article  PubMed  PubMed Central  Google Scholar 

  2. Senzolo M, Ferronato C, Burra P (2009) Neurologic complications after solid organ transplantation. Transpl Int 22:269–278

    Article  PubMed  Google Scholar 

  3. Rodriguez TE (2014) Neurologic complications of bone marrow transplantation. Handb Clin Neurol 121:1295–1304

    Article  PubMed  Google Scholar 

  4. Uckan D, Cetin M, Yigitkanli I, Tezcan I, Tuncer M, Karasimav D, Oguz KK, Topçu M (2005) Life-threatening neurological complications after bone marrow transplantation in children. Bone Marrow Transplant 35:71–76

    Article  CAS  PubMed  Google Scholar 

  5. Garrick R (2000) Neurological complications. In: Atkinson K et al (eds) Clinical bone marrow and blood stem cell transplantation. Cambridge University Press, Cambridge, pp 958–979

    Google Scholar 

  6. Wright AJ, Fishman JA (2014) Central nervous system syndromes in solid organ transplant recipients. Clin Infect Dis 59:1001–1011

    Article  CAS  PubMed  Google Scholar 

  7. Dhar R, Young GB, Marotta P (2008) Perioperative neurological complications after liver transplantation are best predicted by pre-transplant hepatic encephalopathy. Neurocrit Care 8:253–258

    Article  PubMed  Google Scholar 

  8. Zivković SA, Eidelman BH, Bond G, Costa G, Abu-Elmagd KM (2010) The clinical spectrum of neurologic disorders after intestinal and multivisceral transplantation. Clin Transpl 24:164–168

    Article  Google Scholar 

  9. Pérez-Miralles F, Sánchez-Manso JC, Almenar-Bonet L, Sevilla-Mantecón T, Martínez-Dolz L, Vílchez-Padilla JJ (2005) Incidence of and risk factors for neurologic complications after heart transplantation. Transplant Proc 37:4067–4070

    Article  PubMed  Google Scholar 

  10. Zivković S (2007) Neuroimaging and neurologic complications after organ transplantation. J Neuroimaging 17:110–123

    Article  PubMed  Google Scholar 

  11. Guarino M, Benito-Leon J, Decruyenaere J, Schmutzhard E, Weissenborn K, Stracciari A, EFNS (2006) EFNS guidelines on management of neurological problems in liver transplantation. Eur J Neurol 13:2–9

    Article  CAS  PubMed  Google Scholar 

  12. Dhar R, Human T (2011) Central nervous system complications after transplantation. Neurol Clin 29:943–972

    Article  PubMed  Google Scholar 

  13. Stone TJ, Misra SP, McKinstry RC, Vo KD (2015) Imaging of central nervous system complications of hematopoietic stem cell transplant: a chronologic approach to pathology and implications for management. Neurographics 5:133–144

    Article  Google Scholar 

  14. Saiz A, Graus F (2010) Neurologic complications of hematopoietic cell transplantation. Semin Neurol 30:287–295

    Article  PubMed  Google Scholar 

  15. Osborn A (2013) Hydrocephalus and CSF disorders. In: Osborn A (ed) Osborn’s Brain: imaging, pathology and anatomy. Amirsys Inc, pp 1005–1044

  16. Graus F, Saiz A, Sierra J, Arbaiza D, Rovira M, Carreras E, Tolosa E, Rozman C (1996) Neurologic complications of autologous and allogeneic bone marrow transplantation in patients with leukemia: a comparative study. Neurology 46:1004–1009

    Article  CAS  PubMed  Google Scholar 

  17. Pomeranz S, Naparstek E, Ashkenazi E, Nagler A, Lossos A, Slavin S, Or R (1994) Intracranial haematomas following bone marrow transplantation. J Neurol 241:252–256

    Article  CAS  PubMed  Google Scholar 

  18. Colosimo M, McCarthy N, Jayasinghe R, Morton J, Taylor K, Durrant S (2000) Diagnosis and management of subdural haematoma complicating bone marrow transplantation. Bone Marrow Transplant 25:549–552

    Article  CAS  PubMed  Google Scholar 

  19. Coplin WM, Cochran MS, Levine SR, Crawford SW (2001) Stroke after bone marrow transplantation: frequency, aetiology and outcome. Brain 124:1043–1051

    Article  CAS  PubMed  Google Scholar 

  20. Najima Y, Ohashi K, Miyazawa M, Nakano M, Kobayashi T, Yamashita T, Akiyama H, Sakamaki H (2009) Intracranial hemorrhage following allogeneic hematopoietic stem cell transplantation. Am J Hematol 84:298–301

    Article  PubMed  Google Scholar 

  21. Campbell JN, Morris PP (2005) Cerebral vasculitis in graft-versus-host disease: a case report. AJNR Am J Neuroradiol 26:654–656

    PubMed  Google Scholar 

  22. Chen-Plotkin AS, Vossel KA, Samuels MA, Chen MH (2007) Encephalopathy, stroke, and myocardial infarction with DMSO use in stem cell transplantation. Neurology 68:859–861

    Article  PubMed  Google Scholar 

  23. Woywodt A, Haubitz M, Buchholz S, Hertenstein B (2004) Counting the cost: markers of endothelial damage in hematopoietic stem cell transplantation. Bone Marrow Transplant 34:1015–1023

    Article  CAS  PubMed  Google Scholar 

  24. Chen BT, Ortiz AO, Dagis A, Torricelli C, Parker P, Openshaw H (2012) Brain imaging findings in symptomatic patients after allogeneic haematopoietic stem cell transplantation: correlation with clinical outcome. Eur Radiol 22:2273–2281

    Article  PubMed  Google Scholar 

  25. Masetti R, Cordelli DM, Zama D, Vendemini F, Biagi C, Franzoni E, Pession A (2015) PRES in children undergoing hematopoietic stem cell or solid organ transplantation. Pediatrics 135:890–901

    Article  PubMed  Google Scholar 

  26. Gocmen R, Ozgen B, Oguz KK (2007) Widening the spectrum of PRES: series from a tertiary care center. Eur J Radiol 62:454–459

    Article  PubMed  Google Scholar 

  27. Bhatt A, Farooq MU, Majid A, Kassab M (2009) Chemotherapy-related posterior reversible leukoencephalopathy syndrome. Nat Clin Pract Neurol 5:163–169

    Article  CAS  PubMed  Google Scholar 

  28. Nguyen MT, Virk IY, Chew L, Villano JL (2009) Extended use dexamethasone-associated posterior reversible encephalopathy syndrome with cisplatin-based chemotherapy. J Clin Neurosci 16:1688–1690

    Article  PubMed  Google Scholar 

  29. Bartynski WS, Zeigler ZR, Shadduck RK, Lister J (2004) Pretransplantation conditioning influence on the occurrence of cyclosporine or FK-506 neurotoxicity in allogeneic bone marrow transplantation. AJNR Am J Neuroradiol 25:261–269

    PubMed  Google Scholar 

  30. Chen S, Hu J, Xu L, Brandon D, Yu J, Zhang J (2015) Posterior reversible encephalopathy syndrome after transplantation: a review. Mol Neurobiol. doi:10.1007/s12035-015-9560-0

    Google Scholar 

  31. Bartynski WS (2008) Posterior reversible encephalopathy syndrome, part 2: controversies surrounding pathophysiology of vasogenic edema. AJNR Am J Neuroradiol 29:1043–1049

    Article  CAS  PubMed  Google Scholar 

  32. Provenzale JM, Graham ML (1996) Reversible leukoencephalopathy associated with graft-versus-host disease: MR findings. AJNR Am J Neuroradiol 17:1290–1294

    CAS  PubMed  Google Scholar 

  33. McKinney AM, Short J, Truwit CL, McKinney ZJ, Kozak OS, SantaCruz KS, Teksam M (2007) Posterior reversible encephalopathy syndrome: incidence of atypical regions of involvement and imaging findings. AJR Am J Roentgenol 189:904–912

    Article  PubMed  Google Scholar 

  34. Hefzy HM, Bartynski WS, Boardman JF, Lacomis D (2009) Hemorrhage in posterior reversible encephalopathy syndrome: imaging and clinical features. AJNR Am J Neuroradiol 30:1371–1379

    Article  CAS  PubMed  Google Scholar 

  35. Stevens CJ, Heran MK (2012) The many faces of posterior reversible encephalopathy syndrome. Br J Radiol 85:1566–1575

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Cordelli DM, Masetti R, Zama D, Gueraldi D, Rondelli R, Cottone C, Prete A, Pession A, Franzoni E (2014) Etiology, characteristics and outcome of seizures after pediatric hematopoietic stem cell transplantation. Seizure 23:140–145

    Article  PubMed  Google Scholar 

  37. Siegal D, Keller A, Xu W, Bhuta S, Kim DH, Kuruvilla J, Lipton JH, Messner H, Gupta V (2007) Central nervous system complications after allogeneic hematopoietic stem cell transplantation: incidence, manifestations, and clinical significance. Biol Blood Marrow Transplant 13:1369–1379

    Article  PubMed  Google Scholar 

  38. Iguchi A, Kobayashi R, Yoshida M, Kaneda M, Watanabe N, Cho Y, Arioka H, Naito H, Shikano T, Ishikawa Y (1999) Neurological complications after stem cell transplantation in childhood. Bone Marrow Transplant 24:647–652

    Article  CAS  PubMed  Google Scholar 

  39. Bleggi-Torres LF, de Medeiros BC, Werner B, Neto JZ, Loddo G, Pasquini R, de Medeiros CR (2000) Neuropathological findings after bone marrow transplantation: an autopsy study of 180 cases. Bone Marrow Transplant 25:301–307

    Article  CAS  PubMed  Google Scholar 

  40. Gillespie MB, O'Malley BW Jr, Francis HW (1998) An approach to fulminant invasive fungal rhinosinusitis in the immunocompromised host. Arch Otolaryngol Head Neck Surg 124:520–526

    Article  CAS  PubMed  Google Scholar 

  41. DelGaudio JM, Swain RE Jr, Kingdom TT, Muller S, Hudgins PA (2003) Computed tomographic findings in patients with invasive fungal sinusitis. Arch Otolaryngol Head Neck Surg 129:236–240

    Article  PubMed  Google Scholar 

  42. Aribandi M, McCoy VA, Bazan C (2007) Imaging features of invasive and noninvasive fungal sinusitis: a review. Radiographics 27:1283–1296

    Article  PubMed  Google Scholar 

  43. Dietrich U, Hettmann M, Maschke M, Doerfler A, Schwechheimer K, Forsting M (2001) Cerebral aspergillosis: comparison of radiological and neuropathologic findings in patients with bone marrow transplantation. Eur Radiol 11:1242–1249

    Article  CAS  PubMed  Google Scholar 

  44. Nishiguchi T, Mochizuki K, Shakudo M, Takeshita T, Hino M, Inoue Y (2009) CNS complications of hematopoietic stem cell transplantation. AJR Am J Roentgenol 192:1003–1011

    Article  PubMed  Google Scholar 

  45. Antonini G, Ceschin V, Morino S, Fiorelli M, Gragnani F, Mengarelli A, Iori AP, Arcese W (1998) Early neurologic complications following allogeneic bone marrow transplant for leukemia: a prospective study. Neurology 50:1441–1445

    Article  CAS  PubMed  Google Scholar 

  46. Baek JH, Sohn SK, Kim DH, Kim JG, Lee HW, Park SP, Lee KB (2005) Wernicke's encephalopathy after allogeneic stem cell transplantation. Bone Marrow Transplant 35:829–830

    Article  CAS  PubMed  Google Scholar 

  47. Sadighi Z, Sabin ND, Hayden R, Stewart E, Pillai A (2015) Diagnostic clues to human herpesvirus 6 encephalitis and Wernicke encephalopathy after pediatric hematopoietic cell transplantation. J Child Neurol 30:1307–1314

    Article  PubMed  PubMed Central  Google Scholar 

  48. Somech R, Doyle J (2007) Pseudotumor cerebri after allogeneic bone marrow transplant associated with cyclosporine a use for graft-versus-host disease prophylaxis. J Pediatr Hematol Oncol 29:66–68

    Article  CAS  PubMed  Google Scholar 

  49. Hinchey J, Chaves C, Appignani B, Breen J, Pao L, Wang A, Pessin MS, Lamy C, Mas JL, Caplan LR (1996) A reversible posterior leukoencephalopathy syndrome. N Engl J Med 334:494–500

    Article  CAS  PubMed  Google Scholar 

  50. Bartynski WS, Zeigler Z, Spearman MP, Lin L, Shadduck RK, Lister J (2001) Etiology of cortical and white matter lesions in cyclosporin-a and FK-506 neurotoxicity. AJNR Am J Neuroradiol 22:1901–1914

    CAS  PubMed  Google Scholar 

  51. Bartynski WS (2008) Posterior reversible encephalopathy syndrome, part 1: fundamental imaging and clinical features. AJNR Am J Neuroradiol 29:1036–1042

    Article  CAS  PubMed  Google Scholar 

  52. Kim SH, Kim W, Lee KW, Hong EK, Kim HJ (2011) Tumefactive demyelination, an uncommon form of tacrolimus neurotoxicity. Neurology 76:672–674

    Article  CAS  PubMed  Google Scholar 

  53. Fischer SA (2008) Emerging viruses in transplantation: there is more to infection after transplant than CMV and EBV. Transplantation 86:1327–1339

    Article  PubMed  Google Scholar 

  54. Tomblyn M, Young JA, Haagenson MD, Klein JP, Trachtenberg EA, Storek J, Spellman SR, Cooley S, Miller JS, Weisdorf DJ, CIBMTR Infection and Immune Reconstitution Working Committee (2010) Decreased infections in recipients of unrelated donor hematopoietic cell transplantation from donors with an activating KIR genotype. Biol Blood Marrow Transplant 16:1155–1161

    Article  PubMed  PubMed Central  Google Scholar 

  55. Ogata M, Fukuda T, Teshima T (2015) Human herpesvirus-6 encephalitis after allogeneic hematopoietic cell transplantation: what we do and do not know. Bone Marrow Transplant 50:1030–1036

    Article  CAS  PubMed  Google Scholar 

  56. Ogata M, Satou T, Kadota J, Saito N, Yoshida T, Okumura H, Ueki T, Nagafuji K, Kako S, Uoshima N, Tsudo M, Itamura H, Fukuda T (2013) Human herpesvirus 6 (HHV-6) reactivation and HHV-6 encephalitis after allogeneic hematopoietic cell transplantation: a multicenter, prospective study. Clin Infect Dis 57:671–681

    Article  PubMed  Google Scholar 

  57. Hill JA, Koo S, Guzman Suarez BB, Ho VT, Cutler C, Koreth J, Armand P, Alyea EP 3rd, Baden LR, Antin JH, Soiffer RJ, Marty FM (2012) Cord-blood hematopoietic stem cell transplant confers an increased risk for human herpesvirus-6-associated acute limbic encephalitis: a cohort analysis. Biol Blood Marrow Transplant 18:1638–1648

    Article  PubMed  Google Scholar 

  58. Bhanushali MJ, Kranick SM, Freeman AF, Cuellar-Rodriguez JM, Battiwalla M, Gea-Banacloche JC, Hickstein DD, Pavletic S, Fahle G, Nath A (2013) Human herpes 6 virus encephalitis complicating allogeneic hematopoietic stem cell transplantation. Neurology 80:1494–1500

    Article  PubMed  PubMed Central  Google Scholar 

  59. Hill JA, Boeckh MJ, Sedlak RH, Jerome KR, Zerr DM (2014) Human herpesvirus 6 can be detected in cerebrospinal fluid without associated symptoms after allogeneic hematopoietic cell transplantation. J Clin Virol 61:289–292

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  60. Vu T, Carrum G, Hutton G, Heslop HE, Brenner MK, Kamble R (2007) Human herpesvirus-6 encephalitis following allogeneic hematopoietic stem cell transplantation. Bone Marrow Transplant 39:705–709

    Article  CAS  PubMed  Google Scholar 

  61. Shimazu Y, Kondo T, Ishikawa T, Yamashita K, Takaori-Kondo A (2013) Human herpesvirus-6 encephalitis during hematopoietic stem cell transplantation leads to poor prognosis. Transpl Infect Dis 15:195–201

    Article  CAS  PubMed  Google Scholar 

  62. Scheurer ME, Pritchett JC, Amirian ES, Zemke NR, Lusso P, Ljungman P (2013) HHV-6 encephalitis in umbilical cord blood transplantation: a systematic review and meta-analysis. Bone Marrow Transplant 48:574–580

    Article  CAS  PubMed  Google Scholar 

  63. Provenzale JM, vanLandingham KE, Lewis DV, Mukundan S Jr, White LE (2008) Extrahippocampal involvement in human herpesvirus 6 encephalitis depicted at MR imaging. Radiology 249:955–963

    Article  PubMed  Google Scholar 

  64. Ogata M, Kikuchi H, Satou T, Kawano R, Ikewaki J, Kohno K, Kashima K, Ohtsuka E, Kadota J (2006) Human herpesvirus 6 DNA in plasma after allogeneic stem cell transplantation: incidence and clinical significance. J Infect Dis 193:68–79

    Article  CAS  PubMed  Google Scholar 

  65. Muta T, Fukuda T, Harada M (2009) Human herpesvirus-6 encephalitis in hematopoietic SCT recipients in Japan: a retrospective multicenter study. Bone Marrow Transplant 43:583–585

    Article  CAS  PubMed  Google Scholar 

  66. Seeley WW, Marty FM, Holmes TM, Upchurch K, Soiffer RJ, Antin JH, Baden LR, Bromfield EB (2007) Post-transplant acute limbic encephalitis: clinical features and relationship to HHV6. Neurology 69:156–165

    Article  CAS  PubMed  Google Scholar 

  67. Wainwright MS, Martin PL, Morse RP, Lacaze M, Provenzale JM, Coleman RE, Morgan MA, Hulette C, Kurtzberg J, Bushnell C, Epstein L, Lewis DV (2001) Human herpesvirus 6 limbic encephalitis after stem cell transplantation. Ann Neurol 50:612–619

    Article  CAS  PubMed  Google Scholar 

  68. Shintaku M, Kaneda D, Tada K, Katano H, Sata T (2010) Human herpes virus 6 encephalomyelitis after bone marrow transplantation: report of an autopsy case. Neuropathology 30:50–55

    Article  PubMed  Google Scholar 

  69. Noguchi T, Yoshiura T, Hiwatashi A, Togao O, Yamashita K, Nagao E, Uchino A, Hasuo K, Atsumi K, Matsuura T, Kuroiwa T, Mihara F, Honda H, Kudo S (2010) CT and MRI findings of human herpesvirus 6-associated encephalopathy: comparison with findings of herpes simplex virus encephalitis. AJR Am J Roentgenol 194:754–760

    Article  PubMed  Google Scholar 

  70. Kotton CN (2007) Zoonoses in solid-organ and hematopoietic stem cell transplant recipients. Clin Infect Dis 44:857–866

    Article  PubMed  Google Scholar 

  71. Fricker-Hidalgo H, Bulabois CE, Brenier-Pinchart MP, Hamidfar R, Garban F, Brion JP, Timsit JF, Cahn JY, Pelloux H (2009) Diagnosis of toxoplasmosis after allogeneic stem cell transplantation: results of DNA detection and serological techniques. Clin Infect Dis 48:e9–e15

    Article  PubMed  Google Scholar 

  72. Maschke M, Dietrich U, Prumbaum M, Kastrup O, Turowski B, Schaefer UW, Diener HC (1999) Opportunistic CNS infection after bone marrow transplantation. Bone Marrow Transplant 23:1167–1176

    Article  CAS  PubMed  Google Scholar 

  73. Avivi I, Wittmann T, Henig I, Kra-Oz Z, Szwarcwort Cohen M, Zuckerman T, Horowitz NA, Benyamini N (2014) Development of multifocal leukoencephalopathy in patients undergoing allogeneic stem cell transplantation-can preemptive detection of John Cunningham virus be useful? Int J Infect Dis 26:107–109

    Article  PubMed  Google Scholar 

  74. Kharfan-Dabaja MA, Ayala E, Greene J, Rojiani A, Murtagh FR, Anasetti C (2007) Two cases of progressive multifocal leukoencephalopathy after allogeneic hematopoietic cell transplantation and a review of the literature. Bone Marrow Transplant 39:101–107

    Article  CAS  PubMed  Google Scholar 

  75. Gheuens S, Pierone G, Peeters P, Koralnik IJ (2010) Progressive multifocal leukoencephalopathy in individuals with minimal or occult immunosuppression. J Neurol Neurosurg Psychiatry 8:247–254

    Article  Google Scholar 

  76. Carson KR, Evens AM, Richey EA, Habermann TM, Focosi D, Seymour JF, Laubach J, Bawn SD, Gordon LI, Winter JN, Furman RR, Vose JM, Zelenetz AD, Mamtani R, Raisch DW, Dorshimer GW, Rosen ST, Muro K, Gottardi-Littell NR, Talley RL, Sartor O, Green D, Major EO, Bennett CL (2009) Progressive multifocal leukoencephalopathy after rituximab therapy in HIV-negative patients: a report of 57 cases from the research on adverse drug events and reports project. Blood 113:4834–4840

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  77. Aksamit AJ Jr (2012) Progressive multifocal leukoencephalopathy. Continuum (Minneap Minn) 18:1374–1391

    Google Scholar 

  78. Tan K, Roda R, Ostrow L, McArthur J, Nath A (2009) PML-IRIS in patients with HIV infection: clinical manifestations and treatment with steroids. Neurology 72:1458–1464

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  79. Grauer O, Wolff D, Bertz H, Greinix H, Kühl JS, Lawitschka A, Lee SJ, Pavletic SZ, Holler E, Kleiter I (2010) Neurological manifestations of chronic graft-versus-host disease after allogeneic haematopoietic stem cell transplantation: report from the consensus conference on clinical practice in chronic graft-versus-host disease. Brain 133:2852–2865

    Article  PubMed  Google Scholar 

  80. Rouah E, Gruber R, Shearer W, Armstrong D, Hawkins EP (1988) Graft-versus-host disease in the central nervous system. A real entity? Am J Clin Pathol 89:543–546

    Article  CAS  PubMed  Google Scholar 

  81. Kamble RT, Chang CC, Sanchez S, Carrum G (2007) Central nervous system graft-versus-host disease: report of two cases and literature review. Bone Marrow Transplant 39:49–52

    Article  CAS  PubMed  Google Scholar 

  82. Jantunen E, Piilonen A, Volin L, Ruutu P, Parkkali T, Koukila-Kähkölä P, Ruutu T (2002) Radiologically guided fine needle lung biopsies in the evaluation of focal pulmonary lesions in allogeneic stem cell transplant recipients. Bone Marrow Transplant 29:353–356

    Article  CAS  PubMed  Google Scholar 

  83. Rüping MJ, Vehreschild JJ, Cornely OA (2008) Patients at high risk of invasive fungal infections: when and how to treat. Drugs 68:1941–1962

    Article  PubMed  Google Scholar 

  84. Pagano L, Ricci P, Montillo M, Cenacchi A, Nosari A, Tonso A, Cudillo L, Chierichini A, Savignano C, Buelli M, Melillo L, La Barbera EO, Sica S, Hohaus S, Bonini A, Bucaneve G, Del Favero A (1996) Localization of aspergillosis to the central nervous system among patients with acute leukemia: report of 14 cases. Gruppo Italiano Malattie Ematologiche dell’Adulto Infection Program. Clin Infect Dis 23:628–630

    Article  CAS  PubMed  Google Scholar 

  85. DeLone DR, Goldstein RA, Petermann G, Salamat MS, Miles JM, Knechtle SJ, Brown WD (1999) Disseminated aspergillosis involving the brain: distribution and imaging characteristics. AJNR Am J Neuroradiol 20:1597–1604

    CAS  PubMed  Google Scholar 

  86. Yuh WT, Nguyen HD, Gao F, Tali ET, Fisher DJ, Mayr NA, Mueller DP, Sato Y, Trigg ME, Gingrich R (1994) Brain parenchymal infection in bone marrow transplantation patients: CT and MR findings. AJR Am J Roentgenol 162:425–430

    Article  CAS  PubMed  Google Scholar 

  87. Hoenigl M, Krause R (2013) Antifungal therapy of aspergillosis of the central nervous system and aspergillus endophthalmitis. Curr Pharm Des 19:3648–3668

    Article  CAS  PubMed  Google Scholar 

  88. Cesaro S, Boaro MP, Pillon M, Calore E, Cermakova I, Perruccio K, Mengoli C, Messina C (2008) Immune reconstitution complicated by CMV retinitis in a pediatric patient who underwent haploidentical CD34+-selected hematopoietic stem cell transplant for acute lymphoblastic leukemia. Int J Hematol 88:145–148

    Article  PubMed  Google Scholar 

  89. Arribas JR, Storch GA, Clifford DB, Tselis AC (1996) Cytomegalovirus encephalitis. Ann Intern Med 125:577–587

    Article  CAS  PubMed  Google Scholar 

  90. Thurnher MM, Thurnher SA, Schindler E (1997) CNS involvement in AIDS: spectrum of CT and MR findings. Eur Radiol 7:1091–1097

    Article  CAS  PubMed  Google Scholar 

  91. Castellano-Sanchez AA, Li S, Qian J, Lagoo A, Weir E, Brat DJ (2004) Primary central nervous system posttransplant lymphoproliferative disorders. Am J Clin Pathol 121:246–253

    Article  PubMed  Google Scholar 

  92. Dharnidharka VR, Webster AC, Martinez OM, Preiksaitis JK, Leblond V, Choquet S (2016) Post-transplant lymphoproliferative disorders. Nat Rev Dis Primers 2:15088. doi:10.1038/nrdp.2015.88

    Article  PubMed  Google Scholar 

  93. Uhlin M, Wikell H, Sundin M, Blennow O, Maeurer M, Ringden O, Winiarski J, Ljungman P, Remberger M, Mattsson J (2014) Risk factors for Epstein-Barr virus-related post-transplant lymphoproliferative disease after allogeneic hematopoietic stem cell transplantation. Haematologica 99:346–352

    Article  PubMed  PubMed Central  Google Scholar 

  94. Pickhardt PJ, Siegel MJ, Hayashi RJ, Kelly M (2000) Posttransplantation lymphoproliferative disorder in children: clinical, histopathologic, and imaging features. Radiology 217:16–25

    Article  CAS  PubMed  Google Scholar 

  95. Pickhardt PJ, Wippold FJ (1999) Neuroimaging in posttransplantation lymphoproliferative disorder. AJR Am J Roentgenol 172:1117–1121

    Article  CAS  PubMed  Google Scholar 

  96. DeAngelis LM (1999) Primary central nervous system lymphoma. Curr Opin Neurol 12:687–691

    Article  CAS  PubMed  Google Scholar 

  97. Lai R, Rosenblum MK, DeAngelis LM (2002) Primary CNS lymphoma: a whole-brain disease? Neurology 59:1557–1562

    Article  PubMed  Google Scholar 

  98. Thurnher MM, Rieger A, Kleibl-Popov C, Settinek U, Henk C, Haberler C, Schindler E (2001) Primary central nervous system lymphoma in AIDS: a wider spectrum of CT and MRI findings. Neuroradiology 43:29–35

    Article  CAS  PubMed  Google Scholar 

  99. Campo E, Swerdlow SH, Harris NL, Pileri S, Stein H, Jaffe ES (2011) The 2008 WHO classification of lymphoid neoplasms and beyond: evolving concepts and practical applications. Blood 117:5019–5032

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  100. Curtis RE, Rowlings PA, Deeg HJ, Shriner DA, Socíe G, Travis LB, Horowitz MM, Witherspoon RP, Hoover RN, Sobocinski KA, Fraumeni JF Jr, Boice JD Jr (1997) Solid cancers after bone marrow transplantation. N Engl J Med 336:897–904

    Article  CAS  PubMed  Google Scholar 

  101. Guermazi A, Miaux Y, Lafitte F, Zahar JR, Gluckman E (2003) CT and MR imaging of central nervous system effects of therapy in patients treated for hematological malignancies. Eur Radiol 13(Suppl 4):L202–L214

    Article  PubMed  Google Scholar 

  102. Chapman SW, Wilson JP (1990) Nocardiosis in transplant recipients. Semin Respir Infect 5:74–79

    CAS  PubMed  Google Scholar 

  103. Armstrong RW, Fung PC (1993) Brainstem encephalitis (rhombencephalitis) due to Listeria monocytogenes: case report and review. Clin Infect Dis 16:689–702

    Article  CAS  PubMed  Google Scholar 

  104. Thurnher MM (2013) Meningitis and ventriculitis. In: Naidich T et al (eds) Imaging of the brain. Elsevier Saunders, Philadelphia, PA, pp 865–876

    Google Scholar 

  105. Chang KH, Han MH, Roh JK, Kim IO, Han MC, Kim CW (1990) Gd-DTPA-enhanced MR imaging of the brain in patients with meningitis: comparison with CT. AJNR Am J Neuroradiol 11:69–76

    CAS  PubMed  Google Scholar 

  106. Kastrup O, Wanke I, Maschke M (2005) Neuroimaging of infections. NeuroRx 2:324–332

    Article  PubMed  PubMed Central  Google Scholar 

  107. Moritani T (2009) Infectious disease. In: Moritani T et al (eds) Diffusion-weighted MR imaging of the brain. Springer-Verlag, Berlin Heidelberg, pp 193–223

    Chapter  Google Scholar 

  108. Castillo M (1999) Imaging brain abscesses with diffusion-weighted and other sequences. AJNR Am J Neuroradiol 20:1193–1194

    CAS  PubMed  Google Scholar 

  109. Patel MP, Kute VB, Gumber MR, Shah PR, Patel HV, Dhananjay KL, Jain SH, Trivedi HL, Vanikar AV (2013) Successful treatment of Nocardia pneumonia with cytomegalovirus retinitis coinfection in a renal transplant recipient. Int Urol Nephrol 45:581–585

    Article  PubMed  Google Scholar 

  110. Del Pozo JL, van de Beek D, Daly RC, Pulido JS, McGregor CG, Patel R (2009) Incidence and clinical characteristics of ocular infections after heart transplantation: a retrospective cohort study. Clin Transpl 23:484–489

    Article  Google Scholar 

  111. Ribalta T, Martinez AJ, Jares P, Muntané J, Miquel R, Claramonte X, Cardesa A (2002) Presence of occult cytomegalovirus infection in the brain after orthotopic liver transplantation. An autopsy study of 83 cases. Virchows Arch 440:166–171

    Article  PubMed  Google Scholar 

  112. Connelly KP, DeWitt LD (1994) Neurologic complications of infectious mononucleosis. Pediatr Neurol 10:181–184

    Article  CAS  PubMed  Google Scholar 

  113. Gilden DH, Kleinschmidt-DeMasters BK, LaGuardia JJ, Mahalingam R, Cohrs RJ (2000) Neurologic complications of the reactivation of varicella-zoster virus. N Engl J Med 342:635–645

    Article  CAS  PubMed  Google Scholar 

  114. Pruitt AA, Graus F, Rosenfeld MR (2013) Neurological complications of solid organ transplantation. Neurohospitalist 3:152–166

    Article  PubMed  PubMed Central  Google Scholar 

  115. Yehia B, Davison A, Sisson S (2009) Transplant troubles. Am J Med 122:629–631

    Article  PubMed  Google Scholar 

  116. Mateen FJ, Muralidharan R, Carone M, van de Beek D, Harrison DM, Aksamit AJ, Gould MS, Clifford DB, Nath A (2011) Progressive multifocal leukoencephalopathy in transplant recipients. Ann Neurol 70:305–322

    Article  PubMed  PubMed Central  Google Scholar 

  117. DeSalvo D, Roy-Chaudhury P, Peddi R, Merchen T, Konijetti K, Gupta M, Boardman R, Rogers C, Buell J, Hanaway M, Broderick J, Smith R, Woodle ES (2004) West Nile virus encephalitis in organ transplant recipients: another high-risk group for meningoencephalitis and death. Transplantation 77:466–469

    Article  PubMed  Google Scholar 

  118. Burton EC, Burns DK, Opatowsky MJ, El-Feky WH, Fischbach B, Melton L, Sanchez E, Randall H, Watkins DL, Chang J, Klintmalm G (2005) Rabies encephalomyelitis: clinical, neuroradiological, and pathological findings in 4 transplant recipients. Arch Neurol 62:873–882

    Article  PubMed  Google Scholar 

  119. Singh N, Dromer F, Perfect JR, Lortholary O (2008) Cryptococcosis in solid organ transplant recipients: current state of the science. Clin Infect Dis 47:1321–1327

    Article  PubMed  PubMed Central  Google Scholar 

  120. Singh N, Lortholary O, Dromer F, Alexander BD, Gupta KL, John GT, del Busto R, Klintmalm GB, Somani J, Lyon GM, Pursell K, Stosor V, Munoz P, Limaye AP, Kalil AC, Pruett TL, Garcia-Diaz J, Humar A, Houston S, House AA, Wray D, Orloff S, Dowdy LA, Fisher RA, Heitman J, Wagener MM, Husain S, Cryptococcal Collaborative Transplant Study Group (2008) Central nervous system cryptococcosis in solid organ transplant recipients: clinical relevance of abnormal neuroimaging findings. Transplantation 86:647–651

    Article  PubMed  PubMed Central  Google Scholar 

  121. Wu G, Vilchez RA, Eidelman B, Fung J, Kormos R, Kusne S (2002) Cryptococcal meningitis: an analysis among 5,521 consecutive organ transplant recipients. Transpl Infect Dis 4:183–188

    Article  CAS  PubMed  Google Scholar 

  122. Christophe C, Azzi N, Bouché B, Dan B, Levivier M, Ferster A (1999) Magnetic resonance imaging and angiography in cerebral fungal vasculitis. Neuropediatrics 30:218–220

    Article  CAS  PubMed  Google Scholar 

  123. Legris T, Massad M, Purgus R, Vacher-Coponat H, Ranque S, Girard N, Berland Y, Moal V (2011) Immune reconstitution inflammatory syndrome mimicking relapsing cryptococcal meningitis in a renal transplant recipient. Transpl Infect Dis 13:303–308

    Article  CAS  PubMed  Google Scholar 

  124. Singh N, Perfect JR (2007) Immune reconstitution syndrome associated with opportunistic mycoses. Lancet Infect Dis 7:395–401

    Article  PubMed  Google Scholar 

  125. Clay AS, Hainline BE (2007) Hyperammonemia in the ICU. Chest 132:1368–1378

    Article  CAS  PubMed  Google Scholar 

  126. U-King-Im JM, Yu E, Bartlett E, Soobrah R, Kucharczyk W (2011) Acute hyperammonemic encephalopathy in adults: imaging findings. AJNR Am J Neuroradiol 32:413–418

    Article  CAS  PubMed  Google Scholar 

  127. Rosario M, McMahon K, Finelli PF (2013) Diffusion-weighted imaging in acute hyperammonemic encephalopathy. Neurohospitalist 3:125–130

    Article  PubMed  PubMed Central  Google Scholar 

  128. Takanashi J, Barkovich AJ, Cheng SF, Weisiger K, Zlatunich CO, Mudge C, Rosenthal P, Tuchman M, Packman S (2003) Brain MR imaging in neonatal hyperammonemic encephalopathy resulting from proximal urea cycle disorders. AJNR Am J Neuroradiol 24:1184–1187

    PubMed  Google Scholar 

  129. Sureka J, Jakkani RK, Panwar S (2012) MRI findings in acute hyperammonemic encephalopathy resulting from decompensated chronic liver disease. Acta Neurol Belg 112:221–223

    Article  PubMed  Google Scholar 

  130. McKinney AM, Lohman BD, Sarikaya B, Uhlmann E, Spanbauer J, Singewald T, Brace JR (2010) Acute hepatic encephalopathy: diffusion-weighted and fluid-attenuated inversion recovery findings, and correlation with plasma ammonia level and clinical outcome. AJNR Am J Neuroradiol 31:1471–1479

    Article  CAS  PubMed  Google Scholar 

  131. Chang SH, Lim CS, Low TS, Chong HT, Tan SY (2001) Cyclosporine-associated encephalopathy: a case report and literature review. Transplant Proc 33:3700–3701

    Article  CAS  PubMed  Google Scholar 

  132. Parvex P, Pinsk M, Bell LE, O'Gorman AM, Patenaude YG, Gupta IR (2001) Reversible encephalopathy associated with tacrolimus in pediatric renal transplants. Pediatr Nephrol 16:537–542

    Article  CAS  PubMed  Google Scholar 

  133. Inoha S, Inamura T, Nakamizo A, Ikezaki K, Amano T, Fukui M (2002) Magnetic resonance imaging in cases with encephalopathy secondary to immunosuppressive agents. J Clin Neurosci 9:305–307

    Article  PubMed  Google Scholar 

  134. Furukawa M, Terae S, Chu BC, Kaneko K, Kamada H, Miyasaka K (2001) MRI in seven cases of tacrolimus (FK-506) encephalopathy: utility of FLAIR and diffusion-weighted imaging. Neuroradiology 43:615–621

    Article  CAS  PubMed  Google Scholar 

  135. Avila JD, Živković S (2015) The neurology of solid organ transplantation. Curr Neurol Neurosci Rep 15:38

    Article  PubMed  CAS  Google Scholar 

  136. Zierer A, Melby SJ, Voeller RK, Guthrie TJ, Al-Dadah AS, Meyers BF, Pasque MK, Ewald GA, Moon MR, Moazami N (2007) Significance of neurologic complications in the modern era of cardiac transplantation. Ann Thorac Surg 83:1684–1690

    Article  PubMed  Google Scholar 

  137. Jarquin-Valdivia AA, Wijdicks EF, McGregor C (1999) Neurologic complications following heart transplantation in the modern era: decreased incidence, but postoperative stroke remains prevalent. Transplant Proc 31:2161–2162

    Article  CAS  PubMed  Google Scholar 

  138. van de Beek D, Kremers W, Daly RC, Edwards BS, Clavell AL, McGregor CG, Wijdicks EF (2008) Effect of neurologic complications on outcome after heart transplant. Arch Neurol 65:226–231

    PubMed  Google Scholar 

  139. Oliveras A, Roquer J, Puig JM, Rodríguez A, Mir M, Orfila MA, Masramon J, Lloveras J (2003) Stroke in renal transplant recipients: epidemiology, predictive risk factors and outcome. Clin Transpl 17:1–8

    Article  Google Scholar 

  140. Wijdicks EF, Torres VE, Schievink WI, Sterioff S (1999) Cerebral hemorrhage in recipients of renal transplantation. Mayo Clin Proc 74:1111–1112

    Article  CAS  PubMed  Google Scholar 

  141. Wijdicks EF, de Groen PC, Wiesner RH, Krom RA (1995) Intracerebral hemorrhage in liver transplant recipients. Mayo Clin Proc 70:443–446

    Article  CAS  PubMed  Google Scholar 

  142. Gilden DH, Mahalingam R, Cohrs RJ, Kleinschmidt-DeMasters BK, Forghani B (2002) The protean manifestations of varicella-zoster virus vasculopathy. J Neurovirol Suppl 2:75–79

    Article  CAS  Google Scholar 

  143. Penn I (2000) Some problems with posttransplant lymphoproliferative disease. Transplantation 69:705–706

    Article  CAS  PubMed  Google Scholar 

  144. Geissler EK (2015) Post-transplantation malignancies: here today, gone tomorrow? Nat Rev Clin Oncol 12:705–717

    Article  CAS  PubMed  Google Scholar 

  145. Nalesnik MA, Woodle ES, Dimaio JM, Vasudev B, Teperman LW, Covington S, Taranto S, Gockerman JP, Shapiro R, Sharma V, Swinnen LJ, Yoshida A, Ison MG (2011) Donor-transmitted malignancies in organ transplantation: assessment of clinical risk. Am J Transplant 11:1140–1147

    Article  CAS  PubMed  Google Scholar 

  146. Cavaliere R, Petroni G, Lopes MB, Schiff D, International Primary Central Nervous System Lymphoma Collaborative Group (2010) Primary central nervous system post-transplantation lymphoproliferative disorder: an International Primary Central Nervous System Lymphoma Collaborative Group report. Cancer 116:863–870

    Article  PubMed  PubMed Central  Google Scholar 

  147. Evens AM, Choquet S, Kroll-Desrosiers AR, Jagadeesh D, Smith SM, Morschhauser F, Leblond V, Roy R, Barton B, Gordon LI, Gandhi MK, Dierickx D, Schiff D, Habermann TM, Trappe R (2013) Primary CNS posttransplant lymphoproliferative disease (PTLD): an international report of 84 cases in the modern era. Am J Transplant 13:1512–1522

    Article  CAS  PubMed  Google Scholar 

  148. Buell JF, Gross TG, Hanaway MJ, Trofe J, Roy-Chaudhury P, First MR, Woodle ES (2005) Posttransplant lymphoproliferative disorder: significance of central nervous system involvement. Transplant Proc 37:954–955

    Article  CAS  PubMed  Google Scholar 

  149. Kinch A, Cavelier L, Bengtsson M, Baecklund E, Enblad G, Backlin C, Thunberg U, Sundström C, Pauksens K (2014) Donor or recipient origin of posttransplant lymphoproliferative disorders following solid organ transplantation. Am J Transplant 14:2838–2845

    Article  CAS  PubMed  Google Scholar 

  150. Snanoudj R, Durrbach A, Leblond V, Caillard S, Hurault De Ligny B, Noel C, Rondeau E, Moulin B, Mamzer-Bruneel MF, Lacroix C, Charpentier B (2003) Primary brain lymphomas after kidney transplantation: presentation and outcome. Transplantation 76:930–937

    Article  PubMed  Google Scholar 

  151. Phan TG, O'Neill BP, Kurtin PJ (2000) Posttransplant primary CNS lymphoma. Neuro-Oncology 2:229–238

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  152. Schiff D, O'Neill B, Wijdicks E, Antin JH, Wen PY (2001) Gliomas arising in organ transplant recipients: an unrecognized complication of transplantation? Neurology 57:1486–1488

    Article  CAS  PubMed  Google Scholar 

  153. Fatt MA, Horton KM, Fishman EK (2008) Transmission of metastatic glioblastoma multiforme from donor to lung transplant recipient. J Comput Assist Tomogr 32:407–409

    Article  PubMed  Google Scholar 

  154. Penn I (1996) Malignant melanoma in organ allograft recipients. Transplantation 61:274–278

    Article  CAS  PubMed  Google Scholar 

  155. Muñoz P, Valerio M, Palomo J, Fernández-Yáñez J, Fernández-Cruz A, Guinea J, Bouza E (2010) Infectious and non-infectious neurologic complications in heart transplant recipients. Medicine (Baltimore) 89:166–175

    Article  Google Scholar 

  156. Mateen FJ, Dierkhising RA, Rabinstein AA, van de Beek D, Wijdicks EF (2010) Neurological complications following adult lung transplantation. Am J Transplan 10:908–914

    Article  CAS  Google Scholar 

  157. Zivković SA, Jumaa M, Barisić N, McCurry K (2009) Neurologic complications following lung transplantation. J Neurol Sci 280:90–93

    Article  PubMed  Google Scholar 

  158. Adams HP Jr, Dawson G, Coffman TJ, Corry RJ (1986) Stroke in renal transplant recipients. Arch Neurol 43:113–115

    Article  PubMed  Google Scholar 

  159. Hollenbeak CS, Todd MM, Billingsley EM, Harper G, Dyer AM, Lengerich EJ (2005) Increased incidence of melanoma in renal transplantation recipients. Cancer 104:1962–1967

    Article  PubMed  Google Scholar 

  160. Evens AM, Roy R, Sterrenberg D, Moll MZ, Chadburn A, Gordon LI (2010) Post-transplantation lymphoproliferative disorders: diagnosis, prognosis, and current approaches to therapy. Curr Oncol Rep 12:383–394

    Article  PubMed  Google Scholar 

  161. Ponticelli C, Campise MR (2005) Neurological complications in kidney transplant recipients. J Nephrol 18:521–528

    PubMed  Google Scholar 

  162. Kiok MC (1988) Neurologic complications of pancreas transplants. Neurol Clin 6:367–376

    CAS  PubMed  Google Scholar 

  163. Kim JM, Jung KH, Lee ST, Chu K, Roh JK (2015) Central nervous system complications after liver transplantation. J Clin Neurosci 22:1355–1359

    Article  PubMed  Google Scholar 

  164. Saner FH, Gensicke J, Olde Damink SW, Pavlaković G, Treckmann J, Dammann M, Kaiser GM, Sotiropoulos GC, Radtke A, Koeppen S, Beckebaum S, Cicinnati V, Nadalin S, Malagó M, Paul A, Broelsch CE (2010) Neurologic complications in adult living donor liver transplant patients: an underestimated factor? J Neurol 257:253–258

    Article  PubMed  Google Scholar 

  165. de Groen PC, Aksamit AJ, Rakela J, Forbes GS, Krom RA (1987) Central nervous system toxicity after liver transplantation. The role of cyclosporine and cholesterol. N Engl J Med 317:861–866

    Article  PubMed  Google Scholar 

  166. Ghaus N, Bohlega S, Rezeig M (2001) Neurological complications in liver transplantation. J Neurol 248:1042–1048

    Article  CAS  PubMed  Google Scholar 

  167. Zivković SA (2013) Neurologic complications after liver transplantation. World J Hepatol 5:409–416

    Article  PubMed  PubMed Central  Google Scholar 

  168. Wijdicks EF, Hocker SE (2014) Neurologic complications of liver transplantation. Handb Clin Neurol 121:1257–1266

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Section of Neuroradiology, Department of Radiology and Nuclear Medicine, Oslo University Hospital-Rikshospitalet, Sognsvannsveien 20, 0372, Oslo, Norway

    Andrés Server & John K. Hald

  2. Section of Neuroradiology, Department of Radiology, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain

    Nuria Bargalló

  3. Resonance Magnetic Image Core Facility, Institut d’investigacions Biomédiques August Pi i Sunyer (IDIBARS), Barcelona, Spain

    Nuria Bargalló

  4. Department of Hematology, Oslo University Hospital-Rikshospitalet, Oslo, Norway

    Yngvar Fløisand

  5. Section of Gastroenterology, Department of Transplantation Medicine, Oslo University Hospital-Rikshospitalet, Oslo, Norway

    Jon Sponheim

  6. Department of Neurology, Hospital Clínic, Universitat de Barcelona, Barcelona, Spain

    Francesc Graus

  7. Neuroimmunology Program, Institut d’investigacions Biomédiques August Pi i Sunyer (IDIBARS), Barcelona, Spain

    Francesc Graus

  8. Faculty of Medicine, University of Oslo, Oslo, Norway

    John K. Hald

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  1. Andrés Server
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Server, A., Bargalló, N., Fløisand, Y. et al. Imaging spectrum of central nervous system complications of hematopoietic stem cell and solid organ transplantation.. Neuroradiology 59, 105–126 (2017). https://doi.org/10.1007/s00234-017-1804-4

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